The Diagnostic Value of Neuron-Specific Enolase in Children with Mild Blunt Trauma Requiring Cranial CT Scan
Javad Mozafari, 1 Hassan Motamed, 1 Mohammad Ghasem Hanafi, 2 Bita Fatehifar 3 1Department of Emergency Medicine, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 2Department of Radiology, Ahvaz Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, A...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-01-01
|
| Series: | Open Access Emergency Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-diagnostic-value-of-neuron-specific-enolase-in-children-with-mild--peer-reviewed-article-OAEM |
| _version_ | 1818034677590523904 |
|---|---|
| author | Mozafari J Motamed H Hanafi MG Fatehifar B |
| author_facet | Mozafari J Motamed H Hanafi MG Fatehifar B |
| author_sort | Mozafari J |
| collection | DOAJ |
| description | Javad Mozafari, 1 Hassan Motamed, 1 Mohammad Ghasem Hanafi, 2 Bita Fatehifar 3 1Department of Emergency Medicine, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 2Department of Radiology, Ahvaz Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 3Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranCorrespondence: Hassan MotamedDepartment of Emergency Medicine, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranEmail Hasan_motamed@yahoo.comBackground: The present study was conducted to investigate the relationship between serum levels of enolase and pathological findings obtained from CT scans of the brain in children with mild blunt brain trauma and help with a more accurate diagnosis of brain injuries.Methods: The present observational study was conducted on children presenting with head traumas to the emergency department (ED) of Golestan Hospital in Ahvaz, Iran in 2016. A venous blood sample was immediately taken by the ward nurse from all the eligible patients within 6 hrs of the incident after obtaining their information, performing initial examinations and their initial stabilization. Laboratory serum levels and the corresponding interpretations of CT scans of the brain were collected, recorded and then evaluated and analyzed.Results: A total of 62 children with mild blunt brain trauma were included in the study. A significant difference was observed between the positive CT scan group (2.7± 9.74 μg/L) and the negative group (4.23± 1.33 μg/L) in terms of serum levels of enolase (P< 0.0001). The area under the receiver operating characteristic (ROC) curve was 0.992 for serum levels of enolase in diagnosing brain lesions caused by mild head traumas. Moreover, with a cut-off point of 6.97 μg/L, brain lesions could be detected with a sensitivity of 93.55% and a specificity of 100%.Conclusion: Serum levels of enolase were found to be higher in patients with brain injuries. This highly accurate diagnostic biomarker can be recommended for estimating the presence of brain lesions associated with mild head traumas in infants.Keywords: head trauma, blunt trauma, diagnosis, neuron-specific enolase, children |
| first_indexed | 2024-12-10T06:42:58Z |
| format | Article |
| id | doaj.art-c0faed6182224aaf8c90a01aa3104f0c |
| institution | Directory Open Access Journal |
| issn | 1179-1500 |
| language | English |
| last_indexed | 2024-12-10T06:42:58Z |
| publishDate | 2020-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Open Access Emergency Medicine |
| spelling | doaj.art-c0faed6182224aaf8c90a01aa3104f0c2022-12-22T01:58:44ZengDove Medical PressOpen Access Emergency Medicine1179-15002020-01-01Volume 121551090The Diagnostic Value of Neuron-Specific Enolase in Children with Mild Blunt Trauma Requiring Cranial CT ScanMozafari JMotamed HHanafi MGFatehifar BJavad Mozafari, 1 Hassan Motamed, 1 Mohammad Ghasem Hanafi, 2 Bita Fatehifar 3 1Department of Emergency Medicine, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 2Department of Radiology, Ahvaz Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 3Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranCorrespondence: Hassan MotamedDepartment of Emergency Medicine, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranEmail Hasan_motamed@yahoo.comBackground: The present study was conducted to investigate the relationship between serum levels of enolase and pathological findings obtained from CT scans of the brain in children with mild blunt brain trauma and help with a more accurate diagnosis of brain injuries.Methods: The present observational study was conducted on children presenting with head traumas to the emergency department (ED) of Golestan Hospital in Ahvaz, Iran in 2016. A venous blood sample was immediately taken by the ward nurse from all the eligible patients within 6 hrs of the incident after obtaining their information, performing initial examinations and their initial stabilization. Laboratory serum levels and the corresponding interpretations of CT scans of the brain were collected, recorded and then evaluated and analyzed.Results: A total of 62 children with mild blunt brain trauma were included in the study. A significant difference was observed between the positive CT scan group (2.7± 9.74 μg/L) and the negative group (4.23± 1.33 μg/L) in terms of serum levels of enolase (P< 0.0001). The area under the receiver operating characteristic (ROC) curve was 0.992 for serum levels of enolase in diagnosing brain lesions caused by mild head traumas. Moreover, with a cut-off point of 6.97 μg/L, brain lesions could be detected with a sensitivity of 93.55% and a specificity of 100%.Conclusion: Serum levels of enolase were found to be higher in patients with brain injuries. This highly accurate diagnostic biomarker can be recommended for estimating the presence of brain lesions associated with mild head traumas in infants.Keywords: head trauma, blunt trauma, diagnosis, neuron-specific enolase, childrenhttps://www.dovepress.com/the-diagnostic-value-of-neuron-specific-enolase-in-children-with-mild--peer-reviewed-article-OAEMhead traumablunt traumadiagnosisneuron-specific enolasechildren |
| spellingShingle | Mozafari J Motamed H Hanafi MG Fatehifar B The Diagnostic Value of Neuron-Specific Enolase in Children with Mild Blunt Trauma Requiring Cranial CT Scan Open Access Emergency Medicine head trauma blunt trauma diagnosis neuron-specific enolase children |
| title | The Diagnostic Value of Neuron-Specific Enolase in Children with Mild Blunt Trauma Requiring Cranial CT Scan |
| title_full | The Diagnostic Value of Neuron-Specific Enolase in Children with Mild Blunt Trauma Requiring Cranial CT Scan |
| title_fullStr | The Diagnostic Value of Neuron-Specific Enolase in Children with Mild Blunt Trauma Requiring Cranial CT Scan |
| title_full_unstemmed | The Diagnostic Value of Neuron-Specific Enolase in Children with Mild Blunt Trauma Requiring Cranial CT Scan |
| title_short | The Diagnostic Value of Neuron-Specific Enolase in Children with Mild Blunt Trauma Requiring Cranial CT Scan |
| title_sort | diagnostic value of neuron specific enolase in children with mild blunt trauma requiring cranial ct scan |
| topic | head trauma blunt trauma diagnosis neuron-specific enolase children |
| url | https://www.dovepress.com/the-diagnostic-value-of-neuron-specific-enolase-in-children-with-mild--peer-reviewed-article-OAEM |
| work_keys_str_mv | AT mozafarij thediagnosticvalueofneuronspecificenolaseinchildrenwithmildblunttraumarequiringcranialctscan AT motamedh thediagnosticvalueofneuronspecificenolaseinchildrenwithmildblunttraumarequiringcranialctscan AT hanafimg thediagnosticvalueofneuronspecificenolaseinchildrenwithmildblunttraumarequiringcranialctscan AT fatehifarb thediagnosticvalueofneuronspecificenolaseinchildrenwithmildblunttraumarequiringcranialctscan AT mozafarij diagnosticvalueofneuronspecificenolaseinchildrenwithmildblunttraumarequiringcranialctscan AT motamedh diagnosticvalueofneuronspecificenolaseinchildrenwithmildblunttraumarequiringcranialctscan AT hanafimg diagnosticvalueofneuronspecificenolaseinchildrenwithmildblunttraumarequiringcranialctscan AT fatehifarb diagnosticvalueofneuronspecificenolaseinchildrenwithmildblunttraumarequiringcranialctscan |