Depletion of the Origin Recognition Complex Subunits Delays Aging in Budding Yeast

Depletion of the Origin Recognition Complex Subunits Delays Aging in Budding Yeast

Precise DNA replication is pivotal for ensuring the accurate inheritance of genetic information. To avoid genetic instability, each DNA fragment needs to be amplified only once per cell cycle. DNA replication in eukaryotes starts with the binding of the origin recognition complex (ORC) to the origin...

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Bibliographic Details
Main Authors: Karolina Stępień, Adrianna Skoneczna, Monika Kula-Maximenko, Łukasz Jurczyk, Mateusz Mołoń
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
aging
cell cycle
lifespan
ORC
replication
yeast
Online Access:https://www.mdpi.com/2073-4409/11/8/1252

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