Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke?
Stroke represents one of the main causes of disability and death worldwide. The pathological subtypes of stroke are ischemic stroke, the most frequent, and hemorrhagic stroke. Nrf2 is a transcription factor that regulates redox homeostasis. In stress conditions, Nrf2 translocates inside the nucleus...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/14/4875 |
| _version_ | 1797562871442309120 |
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| author | Agnese Gugliandolo Placido Bramanti Emanuela Mazzon |
| author_facet | Agnese Gugliandolo Placido Bramanti Emanuela Mazzon |
| author_sort | Agnese Gugliandolo |
| collection | DOAJ |
| description | Stroke represents one of the main causes of disability and death worldwide. The pathological subtypes of stroke are ischemic stroke, the most frequent, and hemorrhagic stroke. Nrf2 is a transcription factor that regulates redox homeostasis. In stress conditions, Nrf2 translocates inside the nucleus and induces the transcription of enzymes involved in counteracting oxidative stress, endobiotic and xenobiotic metabolism, regulators of inflammation, and others. Different natural compounds, including food and plant-derived components, were shown to be able to activate Nrf2, mediating an antioxidant response. Some of these compounds were tested in stroke experimental models showing several beneficial actions. In this review, we focused on the studies that evidenced the positive effects of natural bioactive compounds in stroke experimental models through the activation of Nrf2 pathway. Interestingly, different natural compounds can activate Nrf2 through multiple pathways, inducing a strong antioxidant response associated with the beneficial effects against stroke. According to several studies, the combination of different bioactive compounds can lead to a better neuroprotection. In conclusion, natural bioactive compounds may represent new therapeutic strategies against stroke. |
| first_indexed | 2024-03-10T18:33:49Z |
| format | Article |
| id | doaj.art-c0fc77b23842452080d59fbe139187f3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:33:49Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c0fc77b23842452080d59fbe139187f32023-11-20T06:23:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012114487510.3390/ijms21144875Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke?Agnese Gugliandolo0Placido Bramanti1Emanuela Mazzon2IRCCS Centro Neurolesi “Bonino Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, ItalyStroke represents one of the main causes of disability and death worldwide. The pathological subtypes of stroke are ischemic stroke, the most frequent, and hemorrhagic stroke. Nrf2 is a transcription factor that regulates redox homeostasis. In stress conditions, Nrf2 translocates inside the nucleus and induces the transcription of enzymes involved in counteracting oxidative stress, endobiotic and xenobiotic metabolism, regulators of inflammation, and others. Different natural compounds, including food and plant-derived components, were shown to be able to activate Nrf2, mediating an antioxidant response. Some of these compounds were tested in stroke experimental models showing several beneficial actions. In this review, we focused on the studies that evidenced the positive effects of natural bioactive compounds in stroke experimental models through the activation of Nrf2 pathway. Interestingly, different natural compounds can activate Nrf2 through multiple pathways, inducing a strong antioxidant response associated with the beneficial effects against stroke. According to several studies, the combination of different bioactive compounds can lead to a better neuroprotection. In conclusion, natural bioactive compounds may represent new therapeutic strategies against stroke.https://www.mdpi.com/1422-0067/21/14/4875strokeoxidative stressnatural compoundNrf2nutraceutics |
| spellingShingle | Agnese Gugliandolo Placido Bramanti Emanuela Mazzon Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke? International Journal of Molecular Sciences stroke oxidative stress natural compound Nrf2 nutraceutics |
| title | Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke? |
| title_full | Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke? |
| title_fullStr | Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke? |
| title_full_unstemmed | Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke? |
| title_short | Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke? |
| title_sort | activation of nrf2 by natural bioactive compounds a promising approach for stroke |
| topic | stroke oxidative stress natural compound Nrf2 nutraceutics |
| url | https://www.mdpi.com/1422-0067/21/14/4875 |
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