Frequency of tuberculous and non-tuberculous mycobacteria in HIV infected patients from Bogota, Colombia
<p>Abstract</p> <p>Background</p> <p>The prevalence of infections by <it>Mycobacterium tuberculosis</it> and non-tuberculous <it>Mycobacterium</it> species in the HIV-infected patient population in Colombia was uncertain despite some pilot studie...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2001-11-01
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| Series: | BMC Infectious Diseases |
| Online Access: | http://www.biomedcentral.com/1471-2334/1/21 |
| _version_ | 1818155171105996800 |
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| author | León Clara I Gómez Bertha de Mendivelson Ellen Bustillo José G Alvarado Fernando S Gómez-Marin Jorge E Murcia-Aranguren Martha I Triana William A Vargas Erwing A Rodríguez Edgar |
| author_facet | León Clara I Gómez Bertha de Mendivelson Ellen Bustillo José G Alvarado Fernando S Gómez-Marin Jorge E Murcia-Aranguren Martha I Triana William A Vargas Erwing A Rodríguez Edgar |
| author_sort | León Clara I |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The prevalence of infections by <it>Mycobacterium tuberculosis</it> and non-tuberculous <it>Mycobacterium</it> species in the HIV-infected patient population in Colombia was uncertain despite some pilot studies. We determined the frequency of isolation of <it>Mycobacterium tuberculosis</it> and of non-tuberculous <it>Mycobacterium</it> species in diverse body fluids of HIV-infected patients in Bogota, Colombia.</p> <p>Methods</p> <p>Patients who attended the three major HIV/AIDS healthcare centres in Bogota were prospectively studied over a six month period. A total of 286 patients were enrolled, 20% of them were hospitalized at some point during the study. Sixty four percent (64%) were classified as stage C, 25% as stage B, and 11% as stage A (CDC staging system, 1993). A total of 1,622 clinical samples (mostly paired samples of blood, sputum, stool, and urine) were processed for acid-fast bacilli (AFB) stain and culture.</p> <p>Results</p> <p>Overall 43 of 1,622 cultures (2.6%) were positive for mycobacteria. Twenty-two sputum samples were positive. Four patients were diagnosed with <it>M. tuberculosis</it> (1.4%). All isolates of <it>M. tuberculosis</it> were sensitive to common anti-tuberculous drugs. <it>M. avium</it> was isolated in thirteen patients (4.5%), but only in three of them the cultures originated from blood. The other isolates were obtained from stool, urine or sputum samples. In three cases, direct AFB smears of blood were positive. Two patients presented simultaneously with <it>M. tuberculosis</it> and <it>M. avium</it>.</p> <p>Conclusions</p> <p>Non-tuberculous <it>Mycobacterium</it> infections are frequent in HIV infected patients in Bogota. The diagnostic sensitivity for infection with tuberculous and non-tuberculous mycobacteria can be increased when diverse body fluids are processed from each patient.</p> |
| first_indexed | 2024-12-11T14:38:09Z |
| format | Article |
| id | doaj.art-c0ff5bac0431485188e37a3e17ebeed1 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-11T14:38:09Z |
| publishDate | 2001-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-c0ff5bac0431485188e37a3e17ebeed12022-12-22T01:02:05ZengBMCBMC Infectious Diseases1471-23342001-11-01112110.1186/1471-2334-1-21Frequency of tuberculous and non-tuberculous mycobacteria in HIV infected patients from Bogota, ColombiaLeón Clara IGómez Berthade Mendivelson EllenBustillo José GAlvarado Fernando SGómez-Marin Jorge EMurcia-Aranguren Martha ITriana William AVargas Erwing ARodríguez Edgar<p>Abstract</p> <p>Background</p> <p>The prevalence of infections by <it>Mycobacterium tuberculosis</it> and non-tuberculous <it>Mycobacterium</it> species in the HIV-infected patient population in Colombia was uncertain despite some pilot studies. We determined the frequency of isolation of <it>Mycobacterium tuberculosis</it> and of non-tuberculous <it>Mycobacterium</it> species in diverse body fluids of HIV-infected patients in Bogota, Colombia.</p> <p>Methods</p> <p>Patients who attended the three major HIV/AIDS healthcare centres in Bogota were prospectively studied over a six month period. A total of 286 patients were enrolled, 20% of them were hospitalized at some point during the study. Sixty four percent (64%) were classified as stage C, 25% as stage B, and 11% as stage A (CDC staging system, 1993). A total of 1,622 clinical samples (mostly paired samples of blood, sputum, stool, and urine) were processed for acid-fast bacilli (AFB) stain and culture.</p> <p>Results</p> <p>Overall 43 of 1,622 cultures (2.6%) were positive for mycobacteria. Twenty-two sputum samples were positive. Four patients were diagnosed with <it>M. tuberculosis</it> (1.4%). All isolates of <it>M. tuberculosis</it> were sensitive to common anti-tuberculous drugs. <it>M. avium</it> was isolated in thirteen patients (4.5%), but only in three of them the cultures originated from blood. The other isolates were obtained from stool, urine or sputum samples. In three cases, direct AFB smears of blood were positive. Two patients presented simultaneously with <it>M. tuberculosis</it> and <it>M. avium</it>.</p> <p>Conclusions</p> <p>Non-tuberculous <it>Mycobacterium</it> infections are frequent in HIV infected patients in Bogota. The diagnostic sensitivity for infection with tuberculous and non-tuberculous mycobacteria can be increased when diverse body fluids are processed from each patient.</p>http://www.biomedcentral.com/1471-2334/1/21 |
| spellingShingle | León Clara I Gómez Bertha de Mendivelson Ellen Bustillo José G Alvarado Fernando S Gómez-Marin Jorge E Murcia-Aranguren Martha I Triana William A Vargas Erwing A Rodríguez Edgar Frequency of tuberculous and non-tuberculous mycobacteria in HIV infected patients from Bogota, Colombia BMC Infectious Diseases |
| title | Frequency of tuberculous and non-tuberculous mycobacteria in HIV infected patients from Bogota, Colombia |
| title_full | Frequency of tuberculous and non-tuberculous mycobacteria in HIV infected patients from Bogota, Colombia |
| title_fullStr | Frequency of tuberculous and non-tuberculous mycobacteria in HIV infected patients from Bogota, Colombia |
| title_full_unstemmed | Frequency of tuberculous and non-tuberculous mycobacteria in HIV infected patients from Bogota, Colombia |
| title_short | Frequency of tuberculous and non-tuberculous mycobacteria in HIV infected patients from Bogota, Colombia |
| title_sort | frequency of tuberculous and non tuberculous mycobacteria in hiv infected patients from bogota colombia |
| url | http://www.biomedcentral.com/1471-2334/1/21 |
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