Analysis of Promoter-Associated Chromatin Interactions Reveals Biologically Relevant Candidate Target Genes at Endometrial Cancer Risk Loci

Analysis of Promoter-Associated Chromatin Interactions Reveals Biologically Relevant Candidate Target Genes at Endometrial Cancer Risk Loci

The identification of target genes at genome-wide association study (GWAS) loci is a major obstacle for GWAS follow-up. To identify candidate target genes at the 16 known endometrial cancer GWAS risk loci, we performed HiChIP chromatin looping analysis of endometrial cell lines. To enrich for enhanc...

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Bibliographic Details
Main Authors: Tracy A. O’Mara, Amanda B. Spurdle, Dylan M. Glubb, Endometrial Cancer Association Consortium
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
endometrial cancer risk
gwas
hichip
h3k27ac
chromatin looping
enhancer
promoter
Online Access:https://www.mdpi.com/2072-6694/11/10/1440

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