The prognostic impact of lung adenocarcinoma predominance classification relating to pathological factors in lobectomy, the Japanese Joint Committee of Lung Cancer Registry Database in 2010
Abstract Objective We studied the prognosis and clinicopathological background of lung adenocarcinoma predominance among patients who underwent lobectomy using data from the Japanese Joint Committee of Lung Cancer Registry. Methods Two thousand eight hundred sixty-three cases were extracted. Recurre...
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BMC
2022-08-01
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| Online Access: | https://doi.org/10.1186/s12885-022-09973-8 |
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| author | Hiroyuki Ito Hiroshi Date Yasushi Shintani Etsuo Miyaoka Ryoichi Nakanishi Mitsutaka Kadokura Shunsuke Endo Masayuki Chida Ichiro Yoshino Hidemi Suzuki the Japanese Joint Committee of Lung Cancer Registry |
| author_facet | Hiroyuki Ito Hiroshi Date Yasushi Shintani Etsuo Miyaoka Ryoichi Nakanishi Mitsutaka Kadokura Shunsuke Endo Masayuki Chida Ichiro Yoshino Hidemi Suzuki the Japanese Joint Committee of Lung Cancer Registry |
| author_sort | Hiroyuki Ito |
| collection | DOAJ |
| description | Abstract Objective We studied the prognosis and clinicopathological background of lung adenocarcinoma predominance among patients who underwent lobectomy using data from the Japanese Joint Committee of Lung Cancer Registry. Methods Two thousand eight hundred sixty-three cases were extracted. Recurrence free survival (RFS) rates, overall survival (OS) rates and clinicopathological factors and epidermal growth factor receptor (EGFR) mutation status were examined. Results Median follow-up period was 65.5 months. Adenocarcinoma predominance was sub-grouped according to OS and RFS rate. In pathological stage I, 5-year RFS and OS rates were respectively 92.2% and 95.8% in group A (adenocarcinoma-in-situ + minimally invasive adenocarcinoma), 89.3% and 92.1% in group B (lepidic), 79.2% and 89.7% in group C (papillary + acinar + variants) and 69.0% and 79.0% in group D (solid + micropapillary). In pathological stage II + IIIA, they were, 43.6% and 72.4% in B, 39.5% and 66.9% in C and 31.0% and 53.7% in D. Group D showed significant worst outcome both in stage I and II + IIIA. Up stage rate from clinical stage I to pathological stage II + IIIA was 0.0%, 3.7%, 15.9% and 33.3%. The frequency of lymph-vessel, vascular, pleura invasion and positive EGFR mutation were 0.0%, 0.0%, 0.0% and 57.1% in group A, 15.6%, 10.0%, 12.1% and 55.1% in B, 36.6%, 31.8%, 29.7% and 44.9% in C, 50.2%, 57.8%, 38.9% and 21.3% in D. In group D, lymph-vessel, vascular and pleura invasion were most, EGFR mutation was least frequent not only in pathological stage I but also stage II + IIIA. In multivariate analysis, age, pathological stage, vascular invasion, and group D were independent factors affected RFS and OS. Conclusion Limited to lobectomy cases, solid + micropapillary was independent prognostic factor both in early and locally advanced stage. Its malignant degree was related to the frequency of pathological invasive factors and EGFR mutation status. |
| first_indexed | 2024-12-10T19:53:19Z |
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| language | English |
| last_indexed | 2024-12-10T19:53:19Z |
| publishDate | 2022-08-01 |
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| spelling | doaj.art-c1036b2d73d6441fa209c971c9c8cb6b2022-12-22T01:35:43ZengBMCBMC Cancer1471-24072022-08-0122111110.1186/s12885-022-09973-8The prognostic impact of lung adenocarcinoma predominance classification relating to pathological factors in lobectomy, the Japanese Joint Committee of Lung Cancer Registry Database in 2010Hiroyuki Ito0Hiroshi Date1Yasushi Shintani2Etsuo Miyaoka3Ryoichi Nakanishi4Mitsutaka Kadokura5Shunsuke Endo6Masayuki Chida7Ichiro Yoshino8Hidemi Suzuki9the Japanese Joint Committee of Lung Cancer RegistryDepartment of Thoracic Surgery, Kanagawa Cancer CenterDepartment of Thoracic Surgery, Kyoto University Graduate School of MedicineDepartment of General Thoracic Surgery, Osaka University Graduate School of MedicineDepartment of Mathematics, Tokyo University of ScienceDepartment of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical SciencesRespiratory Disease Center, Showa University Northern Yokohama HospitalDepartment of Thoracic Surgery, Jichi Medical SchoolDepartment of General Thoracic Surgery, Dokkyo Medical UniversityDepartment of General Thoracic Surgery, Graduate School of Medicine, Chiba UniversityDepartment of General Thoracic Surgery, Graduate School of Medicine, Chiba UniversityAbstract Objective We studied the prognosis and clinicopathological background of lung adenocarcinoma predominance among patients who underwent lobectomy using data from the Japanese Joint Committee of Lung Cancer Registry. Methods Two thousand eight hundred sixty-three cases were extracted. Recurrence free survival (RFS) rates, overall survival (OS) rates and clinicopathological factors and epidermal growth factor receptor (EGFR) mutation status were examined. Results Median follow-up period was 65.5 months. Adenocarcinoma predominance was sub-grouped according to OS and RFS rate. In pathological stage I, 5-year RFS and OS rates were respectively 92.2% and 95.8% in group A (adenocarcinoma-in-situ + minimally invasive adenocarcinoma), 89.3% and 92.1% in group B (lepidic), 79.2% and 89.7% in group C (papillary + acinar + variants) and 69.0% and 79.0% in group D (solid + micropapillary). In pathological stage II + IIIA, they were, 43.6% and 72.4% in B, 39.5% and 66.9% in C and 31.0% and 53.7% in D. Group D showed significant worst outcome both in stage I and II + IIIA. Up stage rate from clinical stage I to pathological stage II + IIIA was 0.0%, 3.7%, 15.9% and 33.3%. The frequency of lymph-vessel, vascular, pleura invasion and positive EGFR mutation were 0.0%, 0.0%, 0.0% and 57.1% in group A, 15.6%, 10.0%, 12.1% and 55.1% in B, 36.6%, 31.8%, 29.7% and 44.9% in C, 50.2%, 57.8%, 38.9% and 21.3% in D. In group D, lymph-vessel, vascular and pleura invasion were most, EGFR mutation was least frequent not only in pathological stage I but also stage II + IIIA. In multivariate analysis, age, pathological stage, vascular invasion, and group D were independent factors affected RFS and OS. Conclusion Limited to lobectomy cases, solid + micropapillary was independent prognostic factor both in early and locally advanced stage. Its malignant degree was related to the frequency of pathological invasive factors and EGFR mutation status.https://doi.org/10.1186/s12885-022-09973-8AdenocarcinomaAdenocarcinoma predominanceLobectomyThe Japanese lung cancer registry |
| spellingShingle | Hiroyuki Ito Hiroshi Date Yasushi Shintani Etsuo Miyaoka Ryoichi Nakanishi Mitsutaka Kadokura Shunsuke Endo Masayuki Chida Ichiro Yoshino Hidemi Suzuki the Japanese Joint Committee of Lung Cancer Registry The prognostic impact of lung adenocarcinoma predominance classification relating to pathological factors in lobectomy, the Japanese Joint Committee of Lung Cancer Registry Database in 2010 BMC Cancer Adenocarcinoma Adenocarcinoma predominance Lobectomy The Japanese lung cancer registry |
| title | The prognostic impact of lung adenocarcinoma predominance classification relating to pathological factors in lobectomy, the Japanese Joint Committee of Lung Cancer Registry Database in 2010 |
| title_full | The prognostic impact of lung adenocarcinoma predominance classification relating to pathological factors in lobectomy, the Japanese Joint Committee of Lung Cancer Registry Database in 2010 |
| title_fullStr | The prognostic impact of lung adenocarcinoma predominance classification relating to pathological factors in lobectomy, the Japanese Joint Committee of Lung Cancer Registry Database in 2010 |
| title_full_unstemmed | The prognostic impact of lung adenocarcinoma predominance classification relating to pathological factors in lobectomy, the Japanese Joint Committee of Lung Cancer Registry Database in 2010 |
| title_short | The prognostic impact of lung adenocarcinoma predominance classification relating to pathological factors in lobectomy, the Japanese Joint Committee of Lung Cancer Registry Database in 2010 |
| title_sort | prognostic impact of lung adenocarcinoma predominance classification relating to pathological factors in lobectomy the japanese joint committee of lung cancer registry database in 2010 |
| topic | Adenocarcinoma Adenocarcinoma predominance Lobectomy The Japanese lung cancer registry |
| url | https://doi.org/10.1186/s12885-022-09973-8 |
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