On the Origin of the 1,000 Hz Peak in the Spectrum of the Human Tympanic Electrical Noise
The spectral analysis of the spontaneous activity recorded with an electrode positioned near the round window of the guinea pig cochlea shows a broad energy peak between 800 and 1,000 Hz. This spontaneous electric activity is called round window noise or ensemble background activity. In guinea pigs,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnins.2017.00395/full |
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| author | Javiera Pardo-Jadue Constantino D. Dragicevic Macarena Bowen Macarena Bowen Macarena Bowen Paul H. Delano Paul H. Delano |
| author_facet | Javiera Pardo-Jadue Constantino D. Dragicevic Macarena Bowen Macarena Bowen Macarena Bowen Paul H. Delano Paul H. Delano |
| author_sort | Javiera Pardo-Jadue |
| collection | DOAJ |
| description | The spectral analysis of the spontaneous activity recorded with an electrode positioned near the round window of the guinea pig cochlea shows a broad energy peak between 800 and 1,000 Hz. This spontaneous electric activity is called round window noise or ensemble background activity. In guinea pigs, the proposed origin of this peak is the random sum of the extracellular field potentials generated by action potentials of auditory nerve neurons. In this study, we used a non-invasive method to record the tympanic electric noise (TEN) in humans by means of a tympanic wick electrode. We recorded a total of 24 volunteers, under silent conditions or in response to stimuli of different modalities, including auditory, vestibular, and motor activity. Our results show a reliable peak of spontaneous activity at ~1,000 Hz in all studied subjects. In addition, we found stimulus-driven responses with broad-band noise that in most subjects produced an increase in the magnitude of the energy band around 1,000 Hz (between 650 and 1,200 Hz). Our results with the vestibular stimulation were not conclusive, as we found responses with all caloric stimuli, including 37°C. No responses were observed with motor tasks, like eye movements or blinking. We demonstrate the feasibility of recording neural activity from the electric noise of the tympanic membrane with a non-invasive method. From our results, we suggest that the 1,000 Hz component of the TEN has a mixed origin including peripheral and central auditory pathways. This research opens up the possibility of future clinical non-invasive techniques for the functional study of auditory and vestibular nerves in humans. |
| first_indexed | 2024-04-12T07:41:23Z |
| format | Article |
| id | doaj.art-c103816185cd49d3abb4d8c7ad7f8b2a |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-12T07:41:23Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-c103816185cd49d3abb4d8c7ad7f8b2a2022-12-22T03:41:48ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2017-07-011110.3389/fnins.2017.00395268569On the Origin of the 1,000 Hz Peak in the Spectrum of the Human Tympanic Electrical NoiseJaviera Pardo-Jadue0Constantino D. Dragicevic1Macarena Bowen2Macarena Bowen3Macarena Bowen4Paul H. Delano5Paul H. Delano6Departamento de Neurociencia, Facultad de Medicina, Universidad de ChileSantiago, ChileDepartamento de Neurociencia, Facultad de Medicina, Universidad de ChileSantiago, ChileDepartamento de Neurociencia, Facultad de Medicina, Universidad de ChileSantiago, ChileDepartamento de Fonoaudiología, Facultad de Medicina, Universidad de ChileSantiago, ChileDepartament of Linguistics, Australian Hearing Hub, Macquarie UniversitySydney, NSW, AustraliaDepartamento de Neurociencia, Facultad de Medicina, Universidad de ChileSantiago, ChileDepartamento de Otorrinolaringología, Hospital Clínico de la Universidad de ChileSantiago, ChileThe spectral analysis of the spontaneous activity recorded with an electrode positioned near the round window of the guinea pig cochlea shows a broad energy peak between 800 and 1,000 Hz. This spontaneous electric activity is called round window noise or ensemble background activity. In guinea pigs, the proposed origin of this peak is the random sum of the extracellular field potentials generated by action potentials of auditory nerve neurons. In this study, we used a non-invasive method to record the tympanic electric noise (TEN) in humans by means of a tympanic wick electrode. We recorded a total of 24 volunteers, under silent conditions or in response to stimuli of different modalities, including auditory, vestibular, and motor activity. Our results show a reliable peak of spontaneous activity at ~1,000 Hz in all studied subjects. In addition, we found stimulus-driven responses with broad-band noise that in most subjects produced an increase in the magnitude of the energy band around 1,000 Hz (between 650 and 1,200 Hz). Our results with the vestibular stimulation were not conclusive, as we found responses with all caloric stimuli, including 37°C. No responses were observed with motor tasks, like eye movements or blinking. We demonstrate the feasibility of recording neural activity from the electric noise of the tympanic membrane with a non-invasive method. From our results, we suggest that the 1,000 Hz component of the TEN has a mixed origin including peripheral and central auditory pathways. This research opens up the possibility of future clinical non-invasive techniques for the functional study of auditory and vestibular nerves in humans.http://journal.frontiersin.org/article/10.3389/fnins.2017.00395/fullelectrocochleographyround window noisetympanic membranespontaneous activityauditory nervevestibular nerve |
| spellingShingle | Javiera Pardo-Jadue Constantino D. Dragicevic Macarena Bowen Macarena Bowen Macarena Bowen Paul H. Delano Paul H. Delano On the Origin of the 1,000 Hz Peak in the Spectrum of the Human Tympanic Electrical Noise Frontiers in Neuroscience electrocochleography round window noise tympanic membrane spontaneous activity auditory nerve vestibular nerve |
| title | On the Origin of the 1,000 Hz Peak in the Spectrum of the Human Tympanic Electrical Noise |
| title_full | On the Origin of the 1,000 Hz Peak in the Spectrum of the Human Tympanic Electrical Noise |
| title_fullStr | On the Origin of the 1,000 Hz Peak in the Spectrum of the Human Tympanic Electrical Noise |
| title_full_unstemmed | On the Origin of the 1,000 Hz Peak in the Spectrum of the Human Tympanic Electrical Noise |
| title_short | On the Origin of the 1,000 Hz Peak in the Spectrum of the Human Tympanic Electrical Noise |
| title_sort | on the origin of the 1 000 hz peak in the spectrum of the human tympanic electrical noise |
| topic | electrocochleography round window noise tympanic membrane spontaneous activity auditory nerve vestibular nerve |
| url | http://journal.frontiersin.org/article/10.3389/fnins.2017.00395/full |
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