Non-canonical role of the SNARE protein Ykt6 in autophagosome-lysosome fusion.

Non-canonical role of the SNARE protein Ykt6 in autophagosome-lysosome fusion.

The autophagosomal SNARE Syntaxin17 (Syx17) forms a complex with Snap29 and Vamp7/8 to promote autophagosome-lysosome fusion via multiple interactions with the tethering complex HOPS. Here we demonstrate that, unexpectedly, one more SNARE (Ykt6) is also required for autophagosome clearance in Drosop...

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Bibliographic Details
Main Authors: Szabolcs Takáts, Gábor Glatz, Győző Szenci, Attila Boda, Gábor V Horváth, Krisztina Hegedűs, Attila L Kovács, Gábor Juhász
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5937789?pdf=render

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