All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease
Age-related neurodegenerative disorders such as Alzheimer’s disease (AD) have become a critical public health issue due to the significantly extended human lifespan, leading to considerable economic and social burdens. Traditional therapies for AD such as medicine and surgery remain ineffective, imp...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1210;epage=1227;aulast=Liang |
| _version_ | 1818983496174010368 |
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| author | Yi-Yao Liang Li-Dan Zhang Xi Luo Li-Li Wu Zhao-Wei Chen Guang-Hao Wei Kai-Qing Zhang Ze-An Du Ren-Zhi Li Kwok-Fai So Ang Li |
| author_facet | Yi-Yao Liang Li-Dan Zhang Xi Luo Li-Li Wu Zhao-Wei Chen Guang-Hao Wei Kai-Qing Zhang Ze-An Du Ren-Zhi Li Kwok-Fai So Ang Li |
| author_sort | Yi-Yao Liang |
| collection | DOAJ |
| description | Age-related neurodegenerative disorders such as Alzheimer’s disease (AD) have become a critical public health issue due to the significantly extended human lifespan, leading to considerable economic and social burdens. Traditional therapies for AD such as medicine and surgery remain ineffective, impractical, and expensive. Many studies have shown that a variety of bioactive substances released by physical exercise (called “exerkines”) help to maintain and improve the normal functions of the brain in terms of cognition, emotion, and psychomotor coordination. Increasing evidence suggests that exerkines may exert beneficial effects in AD as well. This review summarizes the neuroprotective effects of exerkines in AD, focusing on the underlying molecular mechanism and the dynamic expression of exerkines after physical exercise. The findings described in this review will help direct research into novel targets for the treatment of AD and develop customized exercise therapy for individuals of different ages, genders, and health conditions. |
| first_indexed | 2024-12-20T18:04:02Z |
| format | Article |
| id | doaj.art-c1072072f48849a491185624e98639ba |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-20T18:04:02Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-c1072072f48849a491185624e98639ba2022-12-21T19:30:35ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742022-01-011761210122710.4103/1673-5374.325012All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s diseaseYi-Yao LiangLi-Dan ZhangXi LuoLi-Li WuZhao-Wei ChenGuang-Hao WeiKai-Qing ZhangZe-An DuRen-Zhi LiKwok-Fai SoAng LiAge-related neurodegenerative disorders such as Alzheimer’s disease (AD) have become a critical public health issue due to the significantly extended human lifespan, leading to considerable economic and social burdens. Traditional therapies for AD such as medicine and surgery remain ineffective, impractical, and expensive. Many studies have shown that a variety of bioactive substances released by physical exercise (called “exerkines”) help to maintain and improve the normal functions of the brain in terms of cognition, emotion, and psychomotor coordination. Increasing evidence suggests that exerkines may exert beneficial effects in AD as well. This review summarizes the neuroprotective effects of exerkines in AD, focusing on the underlying molecular mechanism and the dynamic expression of exerkines after physical exercise. The findings described in this review will help direct research into novel targets for the treatment of AD and develop customized exercise therapy for individuals of different ages, genders, and health conditions.http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1210;epage=1227;aulast=Liangalzheimer′s disease; amyloid beta; central nervous system; exerkine; neurodegeneration; neuroinflammation; neuroprotection; oxidative stress; physical exercise; tau protein |
| spellingShingle | Yi-Yao Liang Li-Dan Zhang Xi Luo Li-Li Wu Zhao-Wei Chen Guang-Hao Wei Kai-Qing Zhang Ze-An Du Ren-Zhi Li Kwok-Fai So Ang Li All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease Neural Regeneration Research alzheimer′s disease; amyloid beta; central nervous system; exerkine; neurodegeneration; neuroinflammation; neuroprotection; oxidative stress; physical exercise; tau protein |
| title | All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease |
| title_full | All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease |
| title_fullStr | All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease |
| title_full_unstemmed | All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease |
| title_short | All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease |
| title_sort | all roads lead to rome a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in alzheimer s disease |
| topic | alzheimer′s disease; amyloid beta; central nervous system; exerkine; neurodegeneration; neuroinflammation; neuroprotection; oxidative stress; physical exercise; tau protein |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1210;epage=1227;aulast=Liang |
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