Mannosyltransferase (GPI-14) overexpression protects promastigote and amastigote forms of Leishmania braziliensis against trivalent antimony

Mannosyltransferase (GPI-14) overexpression protects promastigote and amastigote forms of Leishmania braziliensis against trivalent antimony

Abstract Background Glycosylphosphatidylinositol is a surface molecule important for host-parasite interactions. Mannosyltransferase (GPI-14) is an essential enzyme for adding mannose on the glycosylphosphatidyl group. This study attempted to overexpress the GPI-14 gene in Leishmania braziliensis to...

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Bibliographic Details
Main Authors: Christiana Vargas Ribeiro, Bruna Fonte Boa Rocha, Douglas de Souza Moreira, Vanessa Peruhype-Magalhães, Silvane Maria Fonseca Murta
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Parasites & Vectors
Subjects:
Leishmania braziliensis
Glycosylphosphatidylinositol
Mannosyltransferase
Antimony resistance
Concanavalin-A
Online Access:http://link.springer.com/article/10.1186/s13071-019-3305-2

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