A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment
Natural compounds hold promise in the search for cancer therapies due to their unique chemical structures and combinations that may effectively combat cancer while minimizing toxicity and side effects compared to conventional treatments. Silibinin, a natural lignan, has been found to possess strong...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1349745/full |
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| author | Pantha Prodip Ray Mohammad Ashraful Islam Mohammad Safiqul Islam Aixia Han Peiwu Geng Md. Abdul Aziz Abdullah Al Mamun |
| author_facet | Pantha Prodip Ray Mohammad Ashraful Islam Mohammad Safiqul Islam Aixia Han Peiwu Geng Md. Abdul Aziz Abdullah Al Mamun |
| author_sort | Pantha Prodip Ray |
| collection | DOAJ |
| description | Natural compounds hold promise in the search for cancer therapies due to their unique chemical structures and combinations that may effectively combat cancer while minimizing toxicity and side effects compared to conventional treatments. Silibinin, a natural lignan, has been found to possess strong anti-cancer activity against several types of human cancers based on emerging research. This study aims to provide an overview of the therapeutic potential of silibinin in the treatment and prevention of cancers. A comprehensive search was conducted using various internet databases such as PubMed, Google Scholar, and ScienceDirect to identify relevant research papers. Silibinin has been shown to exhibit anticancer activity against several types of cancers, including liver, lungs, breast, prostate, colorectal, skin, and bladder cancers. Its multifaceted mechanisms of action contribute to its therapeutic effects. Silibinin exerts antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, and anti-angiogenic activities, making it a promising candidate for cancer therapy. One of the key mechanisms underlying the anticancer effects of silibinin is its ability to modulate multiple signaling pathways involved in cancer development and progression. It can inhibit the activation of various oncogenic pathways, including PI3K/Akt, NF-κB, Wnt/β-catenin, and MAPK pathways, thereby suppressing cancer cell proliferation, inducing cell cycle arrest, and promoting apoptosis. Silibinin possesses great potential as an effective treatment agent for cancer. The multifaceted mechanisms of action, favorable safety profile, and potential synergistic effects of silibinin with conventional therapies make it an attractive candidate for further investigation and development as a cancer treatment. However, more extensive clinical studies are necessary to fully establish the efficacy, optimal dosage, and long-term effects of silibinin in cancer treatment. |
| first_indexed | 2024-03-07T19:44:46Z |
| format | Article |
| id | doaj.art-c10e762327d04366a9a46f83946c764e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-07T19:44:46Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-c10e762327d04366a9a46f83946c764e2024-02-29T04:28:05ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-02-011510.3389/fphar.2024.13497451349745A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatmentPantha Prodip Ray0Mohammad Ashraful Islam1Mohammad Safiqul Islam2Aixia Han3Peiwu Geng4Md. Abdul Aziz5Abdullah Al Mamun6Department of Pharmacy, State University of Bangladesh, Dhaka, BangladeshDepartment of Pharmacy, University of Asia Pacific, Dhaka, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali, BangladeshKey Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui of The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui People’s Hospital, Lishui, ChinaKey Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui of The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui People’s Hospital, Lishui, ChinaDepartment of Pharmacy, State University of Bangladesh, Dhaka, BangladeshKey Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui of The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui People’s Hospital, Lishui, ChinaNatural compounds hold promise in the search for cancer therapies due to their unique chemical structures and combinations that may effectively combat cancer while minimizing toxicity and side effects compared to conventional treatments. Silibinin, a natural lignan, has been found to possess strong anti-cancer activity against several types of human cancers based on emerging research. This study aims to provide an overview of the therapeutic potential of silibinin in the treatment and prevention of cancers. A comprehensive search was conducted using various internet databases such as PubMed, Google Scholar, and ScienceDirect to identify relevant research papers. Silibinin has been shown to exhibit anticancer activity against several types of cancers, including liver, lungs, breast, prostate, colorectal, skin, and bladder cancers. Its multifaceted mechanisms of action contribute to its therapeutic effects. Silibinin exerts antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, and anti-angiogenic activities, making it a promising candidate for cancer therapy. One of the key mechanisms underlying the anticancer effects of silibinin is its ability to modulate multiple signaling pathways involved in cancer development and progression. It can inhibit the activation of various oncogenic pathways, including PI3K/Akt, NF-κB, Wnt/β-catenin, and MAPK pathways, thereby suppressing cancer cell proliferation, inducing cell cycle arrest, and promoting apoptosis. Silibinin possesses great potential as an effective treatment agent for cancer. The multifaceted mechanisms of action, favorable safety profile, and potential synergistic effects of silibinin with conventional therapies make it an attractive candidate for further investigation and development as a cancer treatment. However, more extensive clinical studies are necessary to fully establish the efficacy, optimal dosage, and long-term effects of silibinin in cancer treatment.https://www.frontiersin.org/articles/10.3389/fphar.2024.1349745/fullsilibinincancerapoptosisantioxidantanti-inflammatoryanti-proliferative |
| spellingShingle | Pantha Prodip Ray Mohammad Ashraful Islam Mohammad Safiqul Islam Aixia Han Peiwu Geng Md. Abdul Aziz Abdullah Al Mamun A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment Frontiers in Pharmacology silibinin cancer apoptosis antioxidant anti-inflammatory anti-proliferative |
| title | A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment |
| title_full | A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment |
| title_fullStr | A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment |
| title_full_unstemmed | A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment |
| title_short | A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment |
| title_sort | comprehensive evaluation of the therapeutic potential of silibinin a ray of hope in cancer treatment |
| topic | silibinin cancer apoptosis antioxidant anti-inflammatory anti-proliferative |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1349745/full |
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