Burden of diabetic ketoacidosis among patients with diabetes mellitus in Ethiopia: a systematic review and meta-analysis
Objectives This systematic review and meta-analysis aimed to assess the magnitude and determinants of diabetic ketoacidosis (DKA) among patients with diabetes mellitus (DM) in Ethiopia.Design Systematic review and meta-analysis.Participants Age 15 and above all patients with diabetes with the diagno...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-02-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/2/e077151.full |
| _version_ | 1797271206740623360 |
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| author | Eyob Girma Abera Dawit Hailemariam Yesho Fraol Tesfaye Erega Zeleke Alemu Adulo Mahlet Zerabiruk Gebreselasse Ermias Habte Gebremichael |
| author_facet | Eyob Girma Abera Dawit Hailemariam Yesho Fraol Tesfaye Erega Zeleke Alemu Adulo Mahlet Zerabiruk Gebreselasse Ermias Habte Gebremichael |
| author_sort | Eyob Girma Abera |
| collection | DOAJ |
| description | Objectives This systematic review and meta-analysis aimed to assess the magnitude and determinants of diabetic ketoacidosis (DKA) among patients with diabetes mellitus (DM) in Ethiopia.Design Systematic review and meta-analysis.Participants Age 15 and above all patients with diabetes with the diagnosis of DKA in EthiopiaData source PubMed/MEDLINE, Cochrane Library, Science Direct, HINARI, Google Scholar and grey literatures were accessed to find relevant articles. Studies that have been conducted and reported in English language, articles with an available full-text, and observational studies were included. The task of searching sources was carried out from all stated electronic databases performed during 15 April–29 April 2023.Primary and secondary outcome measures Eligible studies were critically appraised by three independent reviewers for methodological quality in the review using standardised critical appraisal instruments from Joanna Briggs Institute (JBI) for observational studies. After the finally extracted studies were exported, systematic review and meta-analysis were conducted using Unified Management, Assessment and Review of Information (JBI SUMARI) (JBI, Adelaide, Australia) and STATA V.17 software. Sensitivity tests were done, and funnel plot inspections with Egger’s test were used to check for publication bias.Result From a total of 19 studies with 6498 study participants, the pooled prevalence of DKA among patients with DM in Ethiopia was 30.92% (95% CI 29.96 to 31.89) with a significant statistical heterogeneity (I2=99.2, p=<0.001). Sensitivity analysis suggested that three studies showed deviations from the estimated pooled prevalence. A funnel plot inspection and Egger’s test indicated the absence of a publication bias.Conclusion This systematic review and meta-analysis revealed that the prevalence of DKA among patients with DM in Ethiopia was 30.92%. Besides, different behavioural and clinical determinants of DKA among patients with DM were identified. However, further studies should be conducted, particularly on the possible determinants of DKA, and different stakeholders should be engaged to minimise its burden. |
| first_indexed | 2024-03-07T13:58:27Z |
| format | Article |
| id | doaj.art-c10ee4087b6a464ca6a9e329eb2019b3 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-07T13:58:27Z |
| publishDate | 2024-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-c10ee4087b6a464ca6a9e329eb2019b32024-03-07T06:50:09ZengBMJ Publishing GroupBMJ Open2044-60552024-02-0114210.1136/bmjopen-2023-077151Burden of diabetic ketoacidosis among patients with diabetes mellitus in Ethiopia: a systematic review and meta-analysisEyob Girma Abera0Dawit Hailemariam Yesho1Fraol Tesfaye Erega2Zeleke Alemu Adulo3Mahlet Zerabiruk Gebreselasse4Ermias Habte Gebremichael5Public Health, Jimma University College of Public Health and Medical Sciences, Jimma, Oromia, EthiopiaSchool of Medicine, Addis Ababa University, Addis Ababa, EthiopiaSchool of Medicine, Addis Ababa University, Addis Ababa, EthiopiaJimma University Clinical Trial Unit, Jimma, Oromia, EthiopiaSchool of Medicine, Jimma University, Jimma, Oromia, EthiopiaDepartment of Internal Medicine, Jimma University, Jimma, Oromia, EthiopiaObjectives This systematic review and meta-analysis aimed to assess the magnitude and determinants of diabetic ketoacidosis (DKA) among patients with diabetes mellitus (DM) in Ethiopia.Design Systematic review and meta-analysis.Participants Age 15 and above all patients with diabetes with the diagnosis of DKA in EthiopiaData source PubMed/MEDLINE, Cochrane Library, Science Direct, HINARI, Google Scholar and grey literatures were accessed to find relevant articles. Studies that have been conducted and reported in English language, articles with an available full-text, and observational studies were included. The task of searching sources was carried out from all stated electronic databases performed during 15 April–29 April 2023.Primary and secondary outcome measures Eligible studies were critically appraised by three independent reviewers for methodological quality in the review using standardised critical appraisal instruments from Joanna Briggs Institute (JBI) for observational studies. After the finally extracted studies were exported, systematic review and meta-analysis were conducted using Unified Management, Assessment and Review of Information (JBI SUMARI) (JBI, Adelaide, Australia) and STATA V.17 software. Sensitivity tests were done, and funnel plot inspections with Egger’s test were used to check for publication bias.Result From a total of 19 studies with 6498 study participants, the pooled prevalence of DKA among patients with DM in Ethiopia was 30.92% (95% CI 29.96 to 31.89) with a significant statistical heterogeneity (I2=99.2, p=<0.001). Sensitivity analysis suggested that three studies showed deviations from the estimated pooled prevalence. A funnel plot inspection and Egger’s test indicated the absence of a publication bias.Conclusion This systematic review and meta-analysis revealed that the prevalence of DKA among patients with DM in Ethiopia was 30.92%. Besides, different behavioural and clinical determinants of DKA among patients with DM were identified. However, further studies should be conducted, particularly on the possible determinants of DKA, and different stakeholders should be engaged to minimise its burden.https://bmjopen.bmj.com/content/14/2/e077151.full |
| spellingShingle | Eyob Girma Abera Dawit Hailemariam Yesho Fraol Tesfaye Erega Zeleke Alemu Adulo Mahlet Zerabiruk Gebreselasse Ermias Habte Gebremichael Burden of diabetic ketoacidosis among patients with diabetes mellitus in Ethiopia: a systematic review and meta-analysis BMJ Open |
| title | Burden of diabetic ketoacidosis among patients with diabetes mellitus in Ethiopia: a systematic review and meta-analysis |
| title_full | Burden of diabetic ketoacidosis among patients with diabetes mellitus in Ethiopia: a systematic review and meta-analysis |
| title_fullStr | Burden of diabetic ketoacidosis among patients with diabetes mellitus in Ethiopia: a systematic review and meta-analysis |
| title_full_unstemmed | Burden of diabetic ketoacidosis among patients with diabetes mellitus in Ethiopia: a systematic review and meta-analysis |
| title_short | Burden of diabetic ketoacidosis among patients with diabetes mellitus in Ethiopia: a systematic review and meta-analysis |
| title_sort | burden of diabetic ketoacidosis among patients with diabetes mellitus in ethiopia a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/14/2/e077151.full |
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