Giant anogenital tumor of Buschke–Löwenstein in a patient living with human immunodeficiency virus/acquired immunodeficiency syndrome: a case report
Abstract Background Buschke–Löwenstein tumor is a giant condyloma acuminata infection that is characterized by degeneration, invasion, and recurrence. It is associated with human papilloma virus infection. It develops around the genital and perineal area, sometimes causing a large budding ulcerated...
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-022-03339-1 |
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| author | Mathurin Kowo Jude-Marcel Nzoume Nsope Mengang Sylvain Raoul Simeni Njonnou Emmanuel Armand Kouotou Paul Jean Adrien Atangana Firmin Ankouane Andoulo |
| author_facet | Mathurin Kowo Jude-Marcel Nzoume Nsope Mengang Sylvain Raoul Simeni Njonnou Emmanuel Armand Kouotou Paul Jean Adrien Atangana Firmin Ankouane Andoulo |
| author_sort | Mathurin Kowo |
| collection | DOAJ |
| description | Abstract Background Buschke–Löwenstein tumor is a giant condyloma acuminata infection that is characterized by degeneration, invasion, and recurrence. It is associated with human papilloma virus infection. It develops around the genital and perineal area, sometimes causing a large budding ulcerated lesion. Although human immunodeficiency virus infection is frequent in Africa, there are few descriptions of Buschke–Löwenstein tumor diagnosis and its management. Screening for other sexually transmitted infections must be systematic among these patients. Case presentation We report herein the case of a 21-year-old African origin male patient who developed a perineal swelling. Physical examination showed evidence of a huge exophytic tumor made up of budding pinkish vegetations, with serrated crests, a ‘’butterfly wing’’ structure, and a cauliflower-like appearance crowned with centrifugal circinate lesions. Multiple condylomatous lesions of the anal margin were also present. The patient tested positive for human immunodeficiency virus (cluster of differentiation 4 count of 119 cells/mm3) and hepatitis B infections. Real-time polymerase chain reaction revealed human papilloma virus-16 and other high-risk human papilloma virus deoxyribonucleic acid. The diagnosis of Buschke–Löwenstein tumor was made on mass biopsy, and the patient underwent multidisciplinary intervention (surgery, podophyllin application, and antiretroviral therapy). Medium-term evolution was, however, fatal due to opportunistic infection. Conclusion Buschke–Löwenstein tumor is a rare tumor associated with human immunodeficiency virus infection. It is more frequent in male human immunodeficiency virus-positive patients. There is a need to screen for other sexually transmitted infections. In most cases, the treatment is surgical, in association with local therapies. However, recurrences are common. |
| first_indexed | 2024-12-13T20:27:54Z |
| format | Article |
| id | doaj.art-c10f6bc503fc4795b5cbc7d05479e608 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-13T20:27:54Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-c10f6bc503fc4795b5cbc7d05479e6082022-12-21T23:32:30ZengBMCJournal of Medical Case Reports1752-19472022-03-011611510.1186/s13256-022-03339-1Giant anogenital tumor of Buschke–Löwenstein in a patient living with human immunodeficiency virus/acquired immunodeficiency syndrome: a case reportMathurin Kowo0Jude-Marcel Nzoume Nsope Mengang1Sylvain Raoul Simeni Njonnou2Emmanuel Armand Kouotou3Paul Jean Adrien Atangana4Firmin Ankouane Andoulo5Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde IDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde IDepartment of Internal Medicine and Specialties, Faculty of Medicine and Pharmaceutical Sciences, University of DschangDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde IDepartment of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of DoualaDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde IAbstract Background Buschke–Löwenstein tumor is a giant condyloma acuminata infection that is characterized by degeneration, invasion, and recurrence. It is associated with human papilloma virus infection. It develops around the genital and perineal area, sometimes causing a large budding ulcerated lesion. Although human immunodeficiency virus infection is frequent in Africa, there are few descriptions of Buschke–Löwenstein tumor diagnosis and its management. Screening for other sexually transmitted infections must be systematic among these patients. Case presentation We report herein the case of a 21-year-old African origin male patient who developed a perineal swelling. Physical examination showed evidence of a huge exophytic tumor made up of budding pinkish vegetations, with serrated crests, a ‘’butterfly wing’’ structure, and a cauliflower-like appearance crowned with centrifugal circinate lesions. Multiple condylomatous lesions of the anal margin were also present. The patient tested positive for human immunodeficiency virus (cluster of differentiation 4 count of 119 cells/mm3) and hepatitis B infections. Real-time polymerase chain reaction revealed human papilloma virus-16 and other high-risk human papilloma virus deoxyribonucleic acid. The diagnosis of Buschke–Löwenstein tumor was made on mass biopsy, and the patient underwent multidisciplinary intervention (surgery, podophyllin application, and antiretroviral therapy). Medium-term evolution was, however, fatal due to opportunistic infection. Conclusion Buschke–Löwenstein tumor is a rare tumor associated with human immunodeficiency virus infection. It is more frequent in male human immunodeficiency virus-positive patients. There is a need to screen for other sexually transmitted infections. In most cases, the treatment is surgical, in association with local therapies. However, recurrences are common.https://doi.org/10.1186/s13256-022-03339-1Buschke–Löwenstein tumorHIV infectionLocal excisionPodophyllin |
| spellingShingle | Mathurin Kowo Jude-Marcel Nzoume Nsope Mengang Sylvain Raoul Simeni Njonnou Emmanuel Armand Kouotou Paul Jean Adrien Atangana Firmin Ankouane Andoulo Giant anogenital tumor of Buschke–Löwenstein in a patient living with human immunodeficiency virus/acquired immunodeficiency syndrome: a case report Journal of Medical Case Reports Buschke–Löwenstein tumor HIV infection Local excision Podophyllin |
| title | Giant anogenital tumor of Buschke–Löwenstein in a patient living with human immunodeficiency virus/acquired immunodeficiency syndrome: a case report |
| title_full | Giant anogenital tumor of Buschke–Löwenstein in a patient living with human immunodeficiency virus/acquired immunodeficiency syndrome: a case report |
| title_fullStr | Giant anogenital tumor of Buschke–Löwenstein in a patient living with human immunodeficiency virus/acquired immunodeficiency syndrome: a case report |
| title_full_unstemmed | Giant anogenital tumor of Buschke–Löwenstein in a patient living with human immunodeficiency virus/acquired immunodeficiency syndrome: a case report |
| title_short | Giant anogenital tumor of Buschke–Löwenstein in a patient living with human immunodeficiency virus/acquired immunodeficiency syndrome: a case report |
| title_sort | giant anogenital tumor of buschke lowenstein in a patient living with human immunodeficiency virus acquired immunodeficiency syndrome a case report |
| topic | Buschke–Löwenstein tumor HIV infection Local excision Podophyllin |
| url | https://doi.org/10.1186/s13256-022-03339-1 |
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