Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics
Phagocytes are the main component of innate immunity. They remove pathogens and particles from organisms using their bactericidal tools in the form of both reactive oxygen species and degrading enzymes—contained in granules—that are potentially toxic proteins. Therefore, it is important to investiga...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-06-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/9/6/150 |
| _version_ | 1811342733178044416 |
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| author | Ewa Jończyk-Matysiak Beata Weber-Dąbrowska Barbara Owczarek Ryszard Międzybrodzki Marzanna Łusiak-Szelachowska Norbert Łodej Andrzej Górski |
| author_facet | Ewa Jończyk-Matysiak Beata Weber-Dąbrowska Barbara Owczarek Ryszard Międzybrodzki Marzanna Łusiak-Szelachowska Norbert Łodej Andrzej Górski |
| author_sort | Ewa Jończyk-Matysiak |
| collection | DOAJ |
| description | Phagocytes are the main component of innate immunity. They remove pathogens and particles from organisms using their bactericidal tools in the form of both reactive oxygen species and degrading enzymes—contained in granules—that are potentially toxic proteins. Therefore, it is important to investigate the possible interactions between phages and immune cells and avoid any phage side effects on them. Recent progress in knowledge concerning the influence of phages on phagocytes is also important as such interactions may shape the immune response. In this review we have summarized the current knowledge on phage interactions with phagocytes described so far and their potential implications for phage therapy. The data suggesting that phage do not downregulate important phagocyte functions are especially relevant for the concept of phage therapy. |
| first_indexed | 2024-04-13T19:15:55Z |
| format | Article |
| id | doaj.art-c11056ca02d841dfae930b7999390f3e |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-13T19:15:55Z |
| publishDate | 2017-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-c11056ca02d841dfae930b7999390f3e2022-12-22T02:33:40ZengMDPI AGViruses1999-49152017-06-019615010.3390/v9060150v9060150Phage-Phagocyte Interactions and Their Implications for Phage Application as TherapeuticsEwa Jończyk-Matysiak0Beata Weber-Dąbrowska1Barbara Owczarek2Ryszard Międzybrodzki3Marzanna Łusiak-Szelachowska4Norbert Łodej5Andrzej Górski6Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla Street 12, 53-114 Wroclaw, PolandBacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla Street 12, 53-114 Wroclaw, PolandBacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla Street 12, 53-114 Wroclaw, PolandBacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla Street 12, 53-114 Wroclaw, PolandBacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla Street 12, 53-114 Wroclaw, PolandBacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla Street 12, 53-114 Wroclaw, PolandBacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla Street 12, 53-114 Wroclaw, PolandPhagocytes are the main component of innate immunity. They remove pathogens and particles from organisms using their bactericidal tools in the form of both reactive oxygen species and degrading enzymes—contained in granules—that are potentially toxic proteins. Therefore, it is important to investigate the possible interactions between phages and immune cells and avoid any phage side effects on them. Recent progress in knowledge concerning the influence of phages on phagocytes is also important as such interactions may shape the immune response. In this review we have summarized the current knowledge on phage interactions with phagocytes described so far and their potential implications for phage therapy. The data suggesting that phage do not downregulate important phagocyte functions are especially relevant for the concept of phage therapy.http://www.mdpi.com/1999-4915/9/6/150phagocytesphagesintracellular killing of bacteriaphagocytosismonocytesgranulocytesdendritic cells |
| spellingShingle | Ewa Jończyk-Matysiak Beata Weber-Dąbrowska Barbara Owczarek Ryszard Międzybrodzki Marzanna Łusiak-Szelachowska Norbert Łodej Andrzej Górski Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics Viruses phagocytes phages intracellular killing of bacteria phagocytosis monocytes granulocytes dendritic cells |
| title | Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics |
| title_full | Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics |
| title_fullStr | Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics |
| title_full_unstemmed | Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics |
| title_short | Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics |
| title_sort | phage phagocyte interactions and their implications for phage application as therapeutics |
| topic | phagocytes phages intracellular killing of bacteria phagocytosis monocytes granulocytes dendritic cells |
| url | http://www.mdpi.com/1999-4915/9/6/150 |
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