| Summary: | A dibenzylbutane-type lignan (<b>16</b>), along with eight furofuran-type (<b>1</b>–<b>8</b>), five furan-type (<b>9</b>–<b>13</b>), two dibenzylbutane-type (<b>14</b> and <b>15</b>), two bibenztetrahydronaphthalene-type lignans (<b>17</b> and <b>18</b>), two neolignans (<b>19</b> and <b>20</b>), and six phenolic derivatives (<b>21</b>–<b>26</b>) were isolated from an MeOH extract of the stem bark of <i>Albizia julibrissin</i> Durazz. The chemical structures of the obtained compounds were elucidated by nuclear magnetic resonance (NMR) and mass spectrometry (MS) analyses. Of the evaluated compounds, 14 were isolated from <i>A. julibrissin</i> and the Fabaceae family for the first time. Anti-inflammatory effects of the isolated analogs were investigated in terms of the inhibition of the nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cells. Ten compounds (<b>10</b>–<b>12</b>, <b>14</b>, and <b>17</b>–<b>22</b>) displayed significant dose-dependent inhibitory effects against the NO production, with IC<sub>50</sub> values ranging from 5.4 to 19.2 µM. Moreover, eight compounds (<b>1</b>–<b>4</b>, <b>9</b>, <b>13</b>, <b>15</b>, and <b>16</b>) exhibited moderate inhibitory activities, with IC<sub>50</sub> values ranging from 21.0 to 62.5 µM.
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