Functionally and structurally distinct fusiform face area(s) in over 1000 participants
The fusiform face area (FFA) is a widely studied region causally involved in face perception. Even though cognitive neuroscientists have been studying the FFA for over two decades, answers to foundational questions regarding the function, architecture, and connectivity of the FFA from a large (N>...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922008862 |
| _version_ | 1797961142563241984 |
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| author | Xiayu Chen Xingyu Liu Benjamin J. Parker Zonglei Zhen Kevin S. Weiner |
| author_facet | Xiayu Chen Xingyu Liu Benjamin J. Parker Zonglei Zhen Kevin S. Weiner |
| author_sort | Xiayu Chen |
| collection | DOAJ |
| description | The fusiform face area (FFA) is a widely studied region causally involved in face perception. Even though cognitive neuroscientists have been studying the FFA for over two decades, answers to foundational questions regarding the function, architecture, and connectivity of the FFA from a large (N>1000) group of participants are still lacking. To fill this gap in knowledge, we quantified these multimodal features of fusiform face-selective regions in 1053 participants in the Human Connectome Project. After manually defining over 4,000 fusiform face-selective regions, we report five main findings. First, 68.76% of hemispheres have two cortically separate regions (pFus-faces/FFA-1 and mFus-faces/FFA-2). Second, in 26.69% of hemispheres, pFus-faces/FFA-1 and mFus-faces/FFA-2 are spatially contiguous, yet are distinct based on functional, architectural, and connectivity metrics. Third, pFus-faces/FFA-1 is more face-selective than mFus-faces/FFA-2, and the two regions have distinct functional connectivity fingerprints. Fourth, pFus-faces/FFA-1 is cortically thinner and more heavily myelinated than mFus-faces/FFA-2. Fifth, face-selective patterns and functional connectivity fingerprints of each region are more similar in monozygotic than dizygotic twins and more so than architectural gradients. As we share our areal definitions with the field, future studies can explore how structural and functional features of these regions will inform theories regarding how visual categories are represented in the brain. |
| first_indexed | 2024-04-11T00:55:50Z |
| format | Article |
| id | doaj.art-c1110a993e544e5489039ecd83ca93da |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-11T00:55:50Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-c1110a993e544e5489039ecd83ca93da2023-01-05T06:23:20ZengElsevierNeuroImage1095-95722023-01-01265119765Functionally and structurally distinct fusiform face area(s) in over 1000 participantsXiayu Chen0Xingyu Liu1Benjamin J. Parker2Zonglei Zhen3Kevin S. Weiner4Faculty of Psychology, Beijing Normal University, Beijing 100875, China; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, ChinaFaculty of Psychology, Beijing Normal University, Beijing 100875, ChinaHelen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, United StatesFaculty of Psychology, Beijing Normal University, Beijing 100875, China; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China; Corresponding author at: Faculty of Psychology, Beijing Normal University, Beijing 100875, ChinaHelen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, United States; Department of Psychology, University of California, Berkeley, CA 94720, United StatesThe fusiform face area (FFA) is a widely studied region causally involved in face perception. Even though cognitive neuroscientists have been studying the FFA for over two decades, answers to foundational questions regarding the function, architecture, and connectivity of the FFA from a large (N>1000) group of participants are still lacking. To fill this gap in knowledge, we quantified these multimodal features of fusiform face-selective regions in 1053 participants in the Human Connectome Project. After manually defining over 4,000 fusiform face-selective regions, we report five main findings. First, 68.76% of hemispheres have two cortically separate regions (pFus-faces/FFA-1 and mFus-faces/FFA-2). Second, in 26.69% of hemispheres, pFus-faces/FFA-1 and mFus-faces/FFA-2 are spatially contiguous, yet are distinct based on functional, architectural, and connectivity metrics. Third, pFus-faces/FFA-1 is more face-selective than mFus-faces/FFA-2, and the two regions have distinct functional connectivity fingerprints. Fourth, pFus-faces/FFA-1 is cortically thinner and more heavily myelinated than mFus-faces/FFA-2. Fifth, face-selective patterns and functional connectivity fingerprints of each region are more similar in monozygotic than dizygotic twins and more so than architectural gradients. As we share our areal definitions with the field, future studies can explore how structural and functional features of these regions will inform theories regarding how visual categories are represented in the brain.http://www.sciencedirect.com/science/article/pii/S1053811922008862Fusiform face areaMultimodal MRIFace selectivityCortical thicknessMyelinationFunctional connectivity |
| spellingShingle | Xiayu Chen Xingyu Liu Benjamin J. Parker Zonglei Zhen Kevin S. Weiner Functionally and structurally distinct fusiform face area(s) in over 1000 participants NeuroImage Fusiform face area Multimodal MRI Face selectivity Cortical thickness Myelination Functional connectivity |
| title | Functionally and structurally distinct fusiform face area(s) in over 1000 participants |
| title_full | Functionally and structurally distinct fusiform face area(s) in over 1000 participants |
| title_fullStr | Functionally and structurally distinct fusiform face area(s) in over 1000 participants |
| title_full_unstemmed | Functionally and structurally distinct fusiform face area(s) in over 1000 participants |
| title_short | Functionally and structurally distinct fusiform face area(s) in over 1000 participants |
| title_sort | functionally and structurally distinct fusiform face area s in over 1000 participants |
| topic | Fusiform face area Multimodal MRI Face selectivity Cortical thickness Myelination Functional connectivity |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922008862 |
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