Metabolomic Analysis Uncovers Energy Supply Disturbance as an Underlying Mechanism of the Development of Alcohol‐Associated Liver Cirrhosis
Alcohol‐associated liver disease (ALD) is caused by alcohol metabolism’s effects on the liver. The underlying mechanisms from a metabolic view in the development of alcohol‐associated liver cirrhosis (ALC) are still elusive. We performed an untargeted serum metabolomic analysis in 14 controls, 16 pa...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2021-06-01
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| Series: | Hepatology Communications |
| Online Access: | https://doi.org/10.1002/hep4.1699 |
| _version_ | 1828045682213126144 |
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| author | Ying Huang Ming Niu Jing Jing Zi‐teng Zhang Xu Zhao Shuai‐shuai Chen Shan‐shan Li Zhuo Shi Ang Huang Zheng‐Sheng Zou Yue‐cheng Yu Xiao‐he Xiao Suthat Liangpunsakul Jia‐bo Wang |
| author_facet | Ying Huang Ming Niu Jing Jing Zi‐teng Zhang Xu Zhao Shuai‐shuai Chen Shan‐shan Li Zhuo Shi Ang Huang Zheng‐Sheng Zou Yue‐cheng Yu Xiao‐he Xiao Suthat Liangpunsakul Jia‐bo Wang |
| author_sort | Ying Huang |
| collection | DOAJ |
| description | Alcohol‐associated liver disease (ALD) is caused by alcohol metabolism’s effects on the liver. The underlying mechanisms from a metabolic view in the development of alcohol‐associated liver cirrhosis (ALC) are still elusive. We performed an untargeted serum metabolomic analysis in 14 controls, 16 patients with ALD without cirrhosis (NC), 27 patients with compensated cirrhosis, and 79 patients with decompensated ALC. We identified two metabolic fingerprints associated with ALC development (38 metabolites) and those associated with hepatic decompensation (64 metabolites) in ALC. The cirrhosis‐associated fingerprint (eigenmetabolite) showed a better capability to differentiate ALC from NC than the aspartate aminotransferase–to‐platelet ratio index score. The eigenmetabolite associated with hepatic decompensation showed an increasing trend during the disease progression and was positively correlated with the Model for End‐Stage Liver Disease score. These metabolic fingerprints belong to the metabolites in lipid metabolism, amino acid pathway, and intermediary metabolites in the tricarboxylic acid cycle. Conclusion: The metabolomic fingerprints suggest the disturbance of the metabolites associated with cellular energy supply as an underlying mechanism in the development and progression of alcoholic cirrhosis. |
| first_indexed | 2024-04-10T18:15:06Z |
| format | Article |
| id | doaj.art-c1112e0de9614e1fa910dd2fbc3f09dc |
| institution | Directory Open Access Journal |
| issn | 2471-254X |
| language | English |
| last_indexed | 2024-04-10T18:15:06Z |
| publishDate | 2021-06-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Hepatology Communications |
| spelling | doaj.art-c1112e0de9614e1fa910dd2fbc3f09dc2023-02-02T09:08:48ZengWolters Kluwer Health/LWWHepatology Communications2471-254X2021-06-015696197510.1002/hep4.1699Metabolomic Analysis Uncovers Energy Supply Disturbance as an Underlying Mechanism of the Development of Alcohol‐Associated Liver CirrhosisYing Huang0Ming Niu1Jing Jing2Zi‐teng Zhang3Xu Zhao4Shuai‐shuai Chen5Shan‐shan Li6Zhuo Shi7Ang Huang8Zheng‐Sheng Zou9Yue‐cheng Yu10Xiao‐he Xiao11Suthat Liangpunsakul12Jia‐bo Wang13School of Pharmacy Hunan University of Chinese Medicine Changsha Hunan ChinaDepartment of Poisoning Treatment Fifth Medical Center of Chinese PLA General Hospital Beijing ChinaChina Military Institute of Chinese MedicineFifth Medical Center of Chinese PLA General Hospital Beijing ChinaChina Military Institute of Chinese MedicineFifth Medical Center of Chinese PLA General Hospital Beijing ChinaChina Military Institute of Chinese MedicineFifth Medical Center of Chinese PLA General Hospital Beijing ChinaChina Military Institute of Chinese MedicineFifth Medical Center of Chinese PLA General Hospital Beijing ChinaChina Military Institute of Chinese MedicineFifth Medical Center of Chinese PLA General Hospital Beijing ChinaChina Military Institute of Chinese MedicineFifth Medical Center of Chinese PLA General Hospital Beijing ChinaCenter for Noninfectious Liver Disease Fifth Medical Center of Chinese PLA General Hospital Beijing ChinaCenter for Noninfectious Liver Disease Fifth Medical Center of Chinese PLA General Hospital Beijing ChinaLiver Diseases Center of General Hospital of PLA Eastern Theater Command and Bayi Hospital Nanjing University of Chinese Medicine Nanjing ChinaChina Military Institute of Chinese MedicineFifth Medical Center of Chinese PLA General Hospital Beijing ChinaDivision of Gastroenterology and Hepatology Department of Medicine Indiana University School of Medicine Indianapolis IN USAChina Military Institute of Chinese MedicineFifth Medical Center of Chinese PLA General Hospital Beijing ChinaAlcohol‐associated liver disease (ALD) is caused by alcohol metabolism’s effects on the liver. The underlying mechanisms from a metabolic view in the development of alcohol‐associated liver cirrhosis (ALC) are still elusive. We performed an untargeted serum metabolomic analysis in 14 controls, 16 patients with ALD without cirrhosis (NC), 27 patients with compensated cirrhosis, and 79 patients with decompensated ALC. We identified two metabolic fingerprints associated with ALC development (38 metabolites) and those associated with hepatic decompensation (64 metabolites) in ALC. The cirrhosis‐associated fingerprint (eigenmetabolite) showed a better capability to differentiate ALC from NC than the aspartate aminotransferase–to‐platelet ratio index score. The eigenmetabolite associated with hepatic decompensation showed an increasing trend during the disease progression and was positively correlated with the Model for End‐Stage Liver Disease score. These metabolic fingerprints belong to the metabolites in lipid metabolism, amino acid pathway, and intermediary metabolites in the tricarboxylic acid cycle. Conclusion: The metabolomic fingerprints suggest the disturbance of the metabolites associated with cellular energy supply as an underlying mechanism in the development and progression of alcoholic cirrhosis.https://doi.org/10.1002/hep4.1699 |
| spellingShingle | Ying Huang Ming Niu Jing Jing Zi‐teng Zhang Xu Zhao Shuai‐shuai Chen Shan‐shan Li Zhuo Shi Ang Huang Zheng‐Sheng Zou Yue‐cheng Yu Xiao‐he Xiao Suthat Liangpunsakul Jia‐bo Wang Metabolomic Analysis Uncovers Energy Supply Disturbance as an Underlying Mechanism of the Development of Alcohol‐Associated Liver Cirrhosis Hepatology Communications |
| title | Metabolomic Analysis Uncovers Energy Supply Disturbance as an Underlying Mechanism of the Development of Alcohol‐Associated Liver Cirrhosis |
| title_full | Metabolomic Analysis Uncovers Energy Supply Disturbance as an Underlying Mechanism of the Development of Alcohol‐Associated Liver Cirrhosis |
| title_fullStr | Metabolomic Analysis Uncovers Energy Supply Disturbance as an Underlying Mechanism of the Development of Alcohol‐Associated Liver Cirrhosis |
| title_full_unstemmed | Metabolomic Analysis Uncovers Energy Supply Disturbance as an Underlying Mechanism of the Development of Alcohol‐Associated Liver Cirrhosis |
| title_short | Metabolomic Analysis Uncovers Energy Supply Disturbance as an Underlying Mechanism of the Development of Alcohol‐Associated Liver Cirrhosis |
| title_sort | metabolomic analysis uncovers energy supply disturbance as an underlying mechanism of the development of alcohol associated liver cirrhosis |
| url | https://doi.org/10.1002/hep4.1699 |
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