Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity

Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity

Cyclin-dependent kinases (CDKs) play an important role in the cell-division cycle. Synthetic inhibitors of CDKs are based on 2,6,9-trisubstituted purines and are developed as potential anticancer drugs; however, they have low solubility in water. In this study, we proved that the pharmaco-chemical p...

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Bibliographic Details
Main Authors: Michal Rouchal, Jana Rudolfová, Vladimír Kryštof, Veronika Vojáčková, Richard Čmelík, Robert Vícha
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
adamantane
2,6,9-trisubstituted purine
cyclin-dependent kinase
cytotoxicity
β-cyclodextrin
molecular docking
Online Access:https://www.mdpi.com/1422-0067/22/23/12675

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