Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low-resource settings
More than 500 000 children die each year in low resource settings due to serious neonatal infections. Better diagnostics that can be utilized in these settings to identify infected infants has the potential to significantly reduce neonatal deaths and the associated morbidity. A systematic review wa...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Edinburgh University Global Health Society
2011-12-01
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| Series: | Journal of Global Health |
| Online Access: | http://www.jogh.org/documents/issue201102/JGH2-10_A5_Wagner.pdf |
| _version_ | 1811225089536950272 |
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| author | Thor A. Wagner Courtney A. Gravett Sara Healy Viju Soma Janna C. Patterson Michael G. Gravett Craig E. Rubens |
| author_facet | Thor A. Wagner Courtney A. Gravett Sara Healy Viju Soma Janna C. Patterson Michael G. Gravett Craig E. Rubens |
| author_sort | Thor A. Wagner |
| collection | DOAJ |
| description | More than 500 000 children die each year in low resource settings
due to serious neonatal infections. Better diagnostics that can be utilized in these settings to identify infected infants has the potential to significantly reduce neonatal deaths and the associated morbidity. A systematic review was performed and identified more than 250 potential new biomarkers for the diagnosis of serious neonatal infections. Eight of these biomarkers were both high-performance and high-abundance (antithrombin, inter-a inhibitor proteins, interferon-g inducible protein-10, interleukin-1 receptor antagonist, LPS binding protein, mannose binding lectin, serum amyloid A, resistin, visfatin), and are promising for the diagnosis of serious neonatal infections
in low resource settings. Future clinical trials comparing these biomarkers with more traditional biomarkers seem warranted. |
| first_indexed | 2024-04-12T08:59:45Z |
| format | Article |
| id | doaj.art-c1162820b7c54c509b407b8699e20b86 |
| institution | Directory Open Access Journal |
| issn | 2047-2978 2047-2986 |
| language | English |
| last_indexed | 2024-04-12T08:59:45Z |
| publishDate | 2011-12-01 |
| publisher | Edinburgh University Global Health Society |
| record_format | Article |
| series | Journal of Global Health |
| spelling | doaj.art-c1162820b7c54c509b407b8699e20b862022-12-22T03:39:16ZengEdinburgh University Global Health SocietyJournal of Global Health2047-29782047-29862011-12-0112210223Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low-resource settingsThor A. Wagner 0Courtney A. Gravett 1Sara Healy 2Viju Soma 3Janna C. Patterson 4Michael G. Gravett 5Craig E. Rubens 6Seattle Children’s, Seattle, Washington, USA; Department of Pediatrics at University of Washington School of Medicine, Seattle, Washington, USAGlobal Alliance to Prevent Prematurity and Stillbirth, an initiative of Seattle Children’s, Seattle, Washington, USASeattle Children’s, Seattle, Washington, USA; Department of Pediatrics at University of Washington School of Medicine, Seattle, Washington, USA; Seattle Biomedical Research Institute, Seattle, Washington, USASeattle Children’s, Seattle, Washington, USA; Department of Pediatrics at University of Washington School of Medicine, Seattle, Washington, USASeattle Children’s, Seattle, Washington, USA; Department of Pediatrics at University of Washington School of Medicine, Seattle, Washington, USAGlobal Alliance to Prevent Prematurity and Stillbirth, an initiative of Seattle Children’s, Seattle, Washington, USA; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USADepartment of Pediatrics at University of Washington School of Medicine, Seattle, Washington, USA; 3 Global Alliance to Prevent Prematurity and Stillbirth, an initiative of Seattle Children’s, Seattle, Washington, USAMore than 500 000 children die each year in low resource settings due to serious neonatal infections. Better diagnostics that can be utilized in these settings to identify infected infants has the potential to significantly reduce neonatal deaths and the associated morbidity. A systematic review was performed and identified more than 250 potential new biomarkers for the diagnosis of serious neonatal infections. Eight of these biomarkers were both high-performance and high-abundance (antithrombin, inter-a inhibitor proteins, interferon-g inducible protein-10, interleukin-1 receptor antagonist, LPS binding protein, mannose binding lectin, serum amyloid A, resistin, visfatin), and are promising for the diagnosis of serious neonatal infections in low resource settings. Future clinical trials comparing these biomarkers with more traditional biomarkers seem warranted.http://www.jogh.org/documents/issue201102/JGH2-10_A5_Wagner.pdf |
| spellingShingle | Thor A. Wagner Courtney A. Gravett Sara Healy Viju Soma Janna C. Patterson Michael G. Gravett Craig E. Rubens Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low-resource settings Journal of Global Health |
| title | Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low-resource settings |
| title_full | Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low-resource settings |
| title_fullStr | Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low-resource settings |
| title_full_unstemmed | Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low-resource settings |
| title_short | Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low-resource settings |
| title_sort | emerging biomarkers for the diagnosis of severe neonatal infections applicable to low resource settings |
| url | http://www.jogh.org/documents/issue201102/JGH2-10_A5_Wagner.pdf |
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