A developmental critical period for ocular dominance plasticity of binocular neurons in mouse superior colliculus
Summary: Detecting visual features in the environment is crucial for animals’ survival. The superior colliculus (SC) is implicated in motion detection and processing, whereas how the SC integrates visual inputs from the two eyes remains unclear. Using in vivo electrophysiology, we show that mouse SC...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723016789 |
| _version_ | 1797362667846893568 |
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| author | Guanglei Hu Ailin Chen Jingjing Ye Qiong Liu Jiafeng Wang Cunxiu Fan Xiaoqing Wang Mengqi Huang Menghan Dai Xuefeng Shi Yu Gu |
| author_facet | Guanglei Hu Ailin Chen Jingjing Ye Qiong Liu Jiafeng Wang Cunxiu Fan Xiaoqing Wang Mengqi Huang Menghan Dai Xuefeng Shi Yu Gu |
| author_sort | Guanglei Hu |
| collection | DOAJ |
| description | Summary: Detecting visual features in the environment is crucial for animals’ survival. The superior colliculus (SC) is implicated in motion detection and processing, whereas how the SC integrates visual inputs from the two eyes remains unclear. Using in vivo electrophysiology, we show that mouse SC contains many binocular neurons that display robust ocular dominance (OD) plasticity in a critical period during early development, which is similar to, but not dependent on, the primary visual cortex. NR2A- and NR2B-containing N-methyl-D-aspartate (NMDA) receptors play an essential role in the regulation of SC plasticity. Blocking NMDA receptors can largely prevent the impairment of predatory hunting caused by monocular deprivation, indicating that maintaining the binocularity of SC neurons is required for efficient hunting behavior. Together, our studies reveal the existence and function of OD plasticity in SC, which broadens our understanding of the development of subcortical visual circuitry relating to motion detection and predatory hunting. |
| first_indexed | 2024-03-08T16:09:43Z |
| format | Article |
| id | doaj.art-c1171e34fe8d421d901c98a8eecc987d |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-08T16:09:43Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-c1171e34fe8d421d901c98a8eecc987d2024-01-08T04:07:25ZengElsevierCell Reports2211-12472024-01-01431113667A developmental critical period for ocular dominance plasticity of binocular neurons in mouse superior colliculusGuanglei Hu0Ailin Chen1Jingjing Ye2Qiong Liu3Jiafeng Wang4Cunxiu Fan5Xiaoqing Wang6Mengqi Huang7Menghan Dai8Xuefeng Shi9Yu Gu10State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China; School of Life Sciences, Westlake University, Hangzhou 310000, ChinaTianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, ChinaTianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China; Medical College of Optometry and Ophthalmology, Shandong University of Traditional Chinese Medicine, Jinan 250014, ChinaSchool of Life Sciences, Westlake University, Hangzhou 310000, ChinaTianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, ChinaJiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai 201803, ChinaDepartment of Dermatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, ChinaState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, ChinaState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, ChinaTianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China; Medical College of Optometry and Ophthalmology, Shandong University of Traditional Chinese Medicine, Jinan 250014, China; Institute of Ophthalmology, Nankai University, Tianjin 300020, China; Corresponding authorState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China; Corresponding authorSummary: Detecting visual features in the environment is crucial for animals’ survival. The superior colliculus (SC) is implicated in motion detection and processing, whereas how the SC integrates visual inputs from the two eyes remains unclear. Using in vivo electrophysiology, we show that mouse SC contains many binocular neurons that display robust ocular dominance (OD) plasticity in a critical period during early development, which is similar to, but not dependent on, the primary visual cortex. NR2A- and NR2B-containing N-methyl-D-aspartate (NMDA) receptors play an essential role in the regulation of SC plasticity. Blocking NMDA receptors can largely prevent the impairment of predatory hunting caused by monocular deprivation, indicating that maintaining the binocularity of SC neurons is required for efficient hunting behavior. Together, our studies reveal the existence and function of OD plasticity in SC, which broadens our understanding of the development of subcortical visual circuitry relating to motion detection and predatory hunting.http://www.sciencedirect.com/science/article/pii/S2211124723016789CP: Neuroscience |
| spellingShingle | Guanglei Hu Ailin Chen Jingjing Ye Qiong Liu Jiafeng Wang Cunxiu Fan Xiaoqing Wang Mengqi Huang Menghan Dai Xuefeng Shi Yu Gu A developmental critical period for ocular dominance plasticity of binocular neurons in mouse superior colliculus Cell Reports CP: Neuroscience |
| title | A developmental critical period for ocular dominance plasticity of binocular neurons in mouse superior colliculus |
| title_full | A developmental critical period for ocular dominance plasticity of binocular neurons in mouse superior colliculus |
| title_fullStr | A developmental critical period for ocular dominance plasticity of binocular neurons in mouse superior colliculus |
| title_full_unstemmed | A developmental critical period for ocular dominance plasticity of binocular neurons in mouse superior colliculus |
| title_short | A developmental critical period for ocular dominance plasticity of binocular neurons in mouse superior colliculus |
| title_sort | developmental critical period for ocular dominance plasticity of binocular neurons in mouse superior colliculus |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723016789 |
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