Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line
This paper reports the synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives 5–8, obtained from the appropriate isatins with pyrrole, with good yields and purity. The product structures were confirmed through spectroscopy methods. Furthermore, the MTT assay on the human liver...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2021-02-01
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| Series: | Open Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/chem-2021-0023 |
| _version_ | 1798030144062881792 |
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| author | Santoso Mardi Fadlan Arif Fahmi Muhammad Riza Ghulam Rahmayanti Ardhana |
| author_facet | Santoso Mardi Fadlan Arif Fahmi Muhammad Riza Ghulam Rahmayanti Ardhana |
| author_sort | Santoso Mardi |
| collection | DOAJ |
| description | This paper reports the synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives 5–8, obtained from the appropriate isatins with pyrrole, with good yields and purity. The product structures were confirmed through spectroscopy methods. Furthermore, the MTT assay on the human liver cancer HepG2 cell lines revealed moderate activity in all compounds, which was highest in sample 6 (IC50 0.47 µM). The anticancer activity was affiliated with the presence of a nitro group at C-5 and N-methyl of the isatin scaffold. |
| first_indexed | 2024-04-11T19:35:28Z |
| format | Article |
| id | doaj.art-c1178cb56fdc4d81a52514ff1686c7d5 |
| institution | Directory Open Access Journal |
| issn | 2391-5420 |
| language | English |
| last_indexed | 2024-04-11T19:35:28Z |
| publishDate | 2021-02-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Chemistry |
| spelling | doaj.art-c1178cb56fdc4d81a52514ff1686c7d52022-12-22T04:06:52ZengDe GruyterOpen Chemistry2391-54202021-02-0119119920410.1515/chem-2021-0023Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell lineSantoso Mardi0Fadlan Arif1Fahmi Muhammad Riza Ghulam2Rahmayanti Ardhana3Department of Chemistry, Faculty of Science, Institut Teknologi Sepuluh Nopember, Kampus ITS Sukolilo, Surabaya, 60111, IndonesiaDepartment of Chemistry, Faculty of Science, Institut Teknologi Sepuluh Nopember, Kampus ITS Sukolilo, Surabaya, 60111, IndonesiaMa Chung Research Center for Photosynthetic Pigments, Universitas Ma Chung, Villa Puncak Tidar N-01, Malang, 65151, IndonesiaDepartment of Environmental Engineering, Faculty of Engineering, Universitas Nahdlatul 10 Ulama Sidoarjo, Jl. Monginsidi Dalam KAV DPR, Sidoklumpuk, Sidoarjo, 61218, IndonesiaThis paper reports the synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives 5–8, obtained from the appropriate isatins with pyrrole, with good yields and purity. The product structures were confirmed through spectroscopy methods. Furthermore, the MTT assay on the human liver cancer HepG2 cell lines revealed moderate activity in all compounds, which was highest in sample 6 (IC50 0.47 µM). The anticancer activity was affiliated with the presence of a nitro group at C-5 and N-methyl of the isatin scaffold.https://doi.org/10.1515/chem-2021-0023isatinisatin-pyrrole derivativesanticancerhepg2 cell line |
| spellingShingle | Santoso Mardi Fadlan Arif Fahmi Muhammad Riza Ghulam Rahmayanti Ardhana Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line Open Chemistry isatin isatin-pyrrole derivatives anticancer hepg2 cell line |
| title | Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line |
| title_full | Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line |
| title_fullStr | Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line |
| title_full_unstemmed | Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line |
| title_short | Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line |
| title_sort | synthesis and in vitro cytotoxicity evaluation of isatin pyrrole derivatives against hepg2 cell line |
| topic | isatin isatin-pyrrole derivatives anticancer hepg2 cell line |
| url | https://doi.org/10.1515/chem-2021-0023 |
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