Infection of cells expressing CXCR4 mutants lacking N-glycosylation at the N-terminal extracellular domain is enhanced for R5X4-dualtropic human immunodeficiency virus type-1

Infection of cells expressing CXCR4 mutants lacking N-glycosylation at the N-terminal extracellular domain is enhanced for R5X4-dualtropic human immunodeficiency virus type-1

<p>Abstract</p> <p>Background</p> <p>Infection with human immunodeficiency virus type-1 (HIV-1) requires binding of the viral envelope gp120 to CD4 and to the CXCR4 coreceptor. Both, gp120 and CXCR4 are subject to N-glycosylation. Here we investigated the influence of t...

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Bibliographic Details
Main Authors: Schreiber Michael, Polzer Svenja, Thordsen Ingo
Format: Article
Language:English
Published: BMC 2002-12-01
Series:BMC Infectious Diseases
Online Access:http://www.biomedcentral.com/1471-2334/2/31

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