Transperitoneal vs retroperitoneal laparoscopic radical nephrectomy: a double-arm, parallel-group randomized clinical trial
Abstract Objective To compare the outcomes of patients undergoing Retroperitoneal laparoscopic Radical nephrectomy (RLRN) and Transperitoneal laparoscopic Radical nephrectomy (TLRN). Methods A total of 120 patients with localized renal cell carcinoma were randomized into either RLRN or TLRN group. M...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Urology |
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| Online Access: | https://doi.org/10.1186/s12894-023-01364-w |
| _version_ | 1827326055908638720 |
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| author | Junyao Liu Bin Zhang Peng Qi Xiaowei Ren Duo Zheng Yang He Xu Zheng Zhongjin Yue Ye Li Ningqiang Yang Zhiping Wang Junsheng Bao Junqiang Tian Li Yang Zhenxing Zhai Lingjun Zuo Zizhen Hou Jiaji Wang Wei Wang Hong Chang Junhai Ma Yunxin Zhang Zhichun Dong Zhilong Dong Ganping Zhong Hui Cheng Pengyuan Lei Zhongming Li GongJin Wu Panfeng Shang |
| author_facet | Junyao Liu Bin Zhang Peng Qi Xiaowei Ren Duo Zheng Yang He Xu Zheng Zhongjin Yue Ye Li Ningqiang Yang Zhiping Wang Junsheng Bao Junqiang Tian Li Yang Zhenxing Zhai Lingjun Zuo Zizhen Hou Jiaji Wang Wei Wang Hong Chang Junhai Ma Yunxin Zhang Zhichun Dong Zhilong Dong Ganping Zhong Hui Cheng Pengyuan Lei Zhongming Li GongJin Wu Panfeng Shang |
| author_sort | Junyao Liu |
| collection | DOAJ |
| description | Abstract Objective To compare the outcomes of patients undergoing Retroperitoneal laparoscopic Radical nephrectomy (RLRN) and Transperitoneal laparoscopic Radical nephrectomy (TLRN). Methods A total of 120 patients with localized renal cell carcinoma were randomized into either RLRN or TLRN group. Mainly by comparing the patient perioperative related data, surgical specimen integrity, pathological results and tumor results. Results Each group comprised 60 patients. The two group were equivalent in terms of perioperative and pathological outcomes. The mean integrity score was significantly lower in the RLRN group than TLRN group. With a median follow-up of 36.4 months after the operation, Kaplan–Meier survival analysis showed no significant difference between RLRN and TLRN in overall survival (89.8% vs. 88.5%; P = 0.898), recurrence-free survival (77.9% vs. 87.7%; P = 0.180), and cancer-specific survival (91.4% vs. 98.3%; P = 0.153). In clinical T2 subgroup, the recurrence rate and recurrence-free survival in the RLRN group was significantly worse than that in the TLRN group (43.2% vs. 76.7%, P = 0.046). Univariate and multivariate COX regression analysis showed that RLRN (HR: 3.35; 95%CI: 1.12–10.03; P = 0.030), male (HR: 4.01; 95%CI: 1.07–14.99; P = 0.039) and tumor size (HR: 1.23; 95%CI: 1.01–1.51; P = 0.042) were independent risk factor for recurrence-free survival. Conclusions Our study showed that although RLRN versus TLRN had roughly similar efficacy, TLRN outperformed RLRN in terms of surgical specimen integrity. TLRN was also significantly better than RLRN in controlling tumor recurrence for clinical T2 and above cases. Trial registration Chinese Clinical Trial Registry ( https://www.chictr.org.cn/showproj.html?proj=24400 ), identifier: ChiCTR1800014431, date: 13/01/2018. |
| first_indexed | 2024-03-07T14:39:07Z |
| format | Article |
| id | doaj.art-c11a27ff07f64f009f9d357da503e5df |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-03-07T14:39:07Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-c11a27ff07f64f009f9d357da503e5df2024-03-05T20:28:43ZengBMCBMC Urology1471-24902024-02-0124111010.1186/s12894-023-01364-wTransperitoneal vs retroperitoneal laparoscopic radical nephrectomy: a double-arm, parallel-group randomized clinical trialJunyao Liu0Bin Zhang1Peng Qi2Xiaowei Ren3Duo Zheng4Yang He5Xu Zheng6Zhongjin Yue7Ye Li8Ningqiang Yang9Zhiping Wang10Junsheng Bao11Junqiang Tian12Li Yang13Zhenxing Zhai14Lingjun Zuo15Zizhen Hou16Jiaji Wang17Wei Wang18Hong Chang19Junhai Ma20Yunxin Zhang21Zhichun Dong22Zhilong Dong23Ganping Zhong24Hui Cheng25Pengyuan Lei26Zhongming Li27GongJin Wu28Panfeng Shang29Department of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalSchool of Public Health, Lanzhou UniversityDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Xigu Branch of Lanzhou University Second HospitalDepartment of Urology, Xigu Branch of Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalDepartment of Urology, Lanzhou University Second HospitalAbstract Objective To compare the outcomes of patients undergoing Retroperitoneal laparoscopic Radical nephrectomy (RLRN) and Transperitoneal laparoscopic Radical nephrectomy (TLRN). Methods A total of 120 patients with localized renal cell carcinoma were randomized into either RLRN or TLRN group. Mainly by comparing the patient perioperative related data, surgical specimen integrity, pathological results and tumor results. Results Each group comprised 60 patients. The two group were equivalent in terms of perioperative and pathological outcomes. The mean integrity score was significantly lower in the RLRN group than TLRN group. With a median follow-up of 36.4 months after the operation, Kaplan–Meier survival analysis showed no significant difference between RLRN and TLRN in overall survival (89.8% vs. 88.5%; P = 0.898), recurrence-free survival (77.9% vs. 87.7%; P = 0.180), and cancer-specific survival (91.4% vs. 98.3%; P = 0.153). In clinical T2 subgroup, the recurrence rate and recurrence-free survival in the RLRN group was significantly worse than that in the TLRN group (43.2% vs. 76.7%, P = 0.046). Univariate and multivariate COX regression analysis showed that RLRN (HR: 3.35; 95%CI: 1.12–10.03; P = 0.030), male (HR: 4.01; 95%CI: 1.07–14.99; P = 0.039) and tumor size (HR: 1.23; 95%CI: 1.01–1.51; P = 0.042) were independent risk factor for recurrence-free survival. Conclusions Our study showed that although RLRN versus TLRN had roughly similar efficacy, TLRN outperformed RLRN in terms of surgical specimen integrity. TLRN was also significantly better than RLRN in controlling tumor recurrence for clinical T2 and above cases. Trial registration Chinese Clinical Trial Registry ( https://www.chictr.org.cn/showproj.html?proj=24400 ), identifier: ChiCTR1800014431, date: 13/01/2018.https://doi.org/10.1186/s12894-023-01364-wRenal cell carcinomaRetroperitoneal approachTransperitoneal approachLaparoscopic radical nephrectomy |
| spellingShingle | Junyao Liu Bin Zhang Peng Qi Xiaowei Ren Duo Zheng Yang He Xu Zheng Zhongjin Yue Ye Li Ningqiang Yang Zhiping Wang Junsheng Bao Junqiang Tian Li Yang Zhenxing Zhai Lingjun Zuo Zizhen Hou Jiaji Wang Wei Wang Hong Chang Junhai Ma Yunxin Zhang Zhichun Dong Zhilong Dong Ganping Zhong Hui Cheng Pengyuan Lei Zhongming Li GongJin Wu Panfeng Shang Transperitoneal vs retroperitoneal laparoscopic radical nephrectomy: a double-arm, parallel-group randomized clinical trial BMC Urology Renal cell carcinoma Retroperitoneal approach Transperitoneal approach Laparoscopic radical nephrectomy |
| title | Transperitoneal vs retroperitoneal laparoscopic radical nephrectomy: a double-arm, parallel-group randomized clinical trial |
| title_full | Transperitoneal vs retroperitoneal laparoscopic radical nephrectomy: a double-arm, parallel-group randomized clinical trial |
| title_fullStr | Transperitoneal vs retroperitoneal laparoscopic radical nephrectomy: a double-arm, parallel-group randomized clinical trial |
| title_full_unstemmed | Transperitoneal vs retroperitoneal laparoscopic radical nephrectomy: a double-arm, parallel-group randomized clinical trial |
| title_short | Transperitoneal vs retroperitoneal laparoscopic radical nephrectomy: a double-arm, parallel-group randomized clinical trial |
| title_sort | transperitoneal vs retroperitoneal laparoscopic radical nephrectomy a double arm parallel group randomized clinical trial |
| topic | Renal cell carcinoma Retroperitoneal approach Transperitoneal approach Laparoscopic radical nephrectomy |
| url | https://doi.org/10.1186/s12894-023-01364-w |
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