A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

Bibliographic Details
Main Authors:	Joshua J. Woods, Neeharika Nemani, Santhanam Shanmughapriya, Akshay Kumar, MengQi Zhang, Sarah R. Nathan, Manfred Thomas, Edmund Carvalho, Karthik Ramachandran, Subramanya Srikantan, Peter B. Stathopulos, Justin J. Wilson, Muniswamy Madesh
Format:	Article
Language:	English
Published:	American Chemical Society 2019-01-01
Series:	ACS Central Science
Online Access:	https://doi.org/10.1021/acscentsci.8b00773

Similar Items

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics
by: Dhanendra Tomar, et al.
Published: (2016-05-01)

The Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Role in Human Diseases
by: Donato D’Angelo, et al.
Published: (2023-08-01)

The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state
by: Anna Weiser, et al.
Published: (2023-08-01)

The mitochondrial Ca2+ uniporter channel synergizes with fluid shear stress to induce mitochondrial Ca2+ oscillations
by: Akshar Patel, et al.
Published: (2022-12-01)

Quantitative analysis of mitochondrial calcium uniporter (MCU) and essential MCU regulator (EMRE) in mitochondria from mouse tissues and HeLa cells
by: Akira Watanabe, et al.
Published: (2022-04-01)

MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity
by: Nicholas E. Hoffman, et al.
Published: (2013-12-01)

Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics
by: Daniel Flicker, et al.
Published: (2019-04-01)

The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex
by: Charles B Phillips, et al.
Published: (2019-01-01)

Gene expression changes of single skeletal muscle fibers in response to modulation of the mitochondrial calcium uniporter (MCU)
by: Francesco Chemello, et al.
Published: (2015-09-01)

Mitochondrial Calcium Uniporter (MCU) deficiency reveals an alternate path for Ca2+ uptake in photoreceptor mitochondria
by: Celia M. Bisbach, et al.
Published: (2020-09-01)

The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells.
by: Andrei I Tarasov, et al.
Published: (2012-01-01)

FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
by: Santhanam Shanmughapriya, et al.
Published: (2018-08-01)

Modulation of the mitochondrial Ca2+ uniporter complex subunit expression by different shear stress patterns in vascular endothelial cells
by: Akshar Patel, et al.
Published: (2023-02-01)

Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation
by: Dhanendra Tomar, et al.
Published: (2019-03-01)

Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis
by: Alejandro Marmolejo-Garza, et al.
Published: (2023-11-01)

Effects of sevoflurane and its metabolite hexafluoroisopropanol on hypoxia/reoxygenation-induced injury and mitochondrial bioenergetics in murine cardiomyocytes
by: Birgit Roth Z'graggen, et al.
Published: (2023-03-01)

Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics
by: Viviane Nascimento Da Conceicao, et al.
Published: (2021-11-01)

MCU encodes the pore conducting mitochondrial calcium currents
by: Dipayan Chaudhuri, et al.
Published: (2013-06-01)

MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress
by: Neeharika Nemani, et al.
Published: (2018-04-01)

The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells
by: Linlin Zhang, et al.
Published: (2022-06-01)

Proteolytic control of the mitochondrial calcium uniporter complex
by: Tsai, Chen-Wei, et al.
Published: (2018)

Monitoring mitochondrial calcium and metabolism in the beating MCU-KO heart
by: Anna Kosmach, et al.
Published: (2021-10-01)

Mitochondrial bioenergetics : methods and protocols /
by: Palmeira, Carlos M., et al.
Published: (c201)

Characterization of Mitochondrial Bioenergetics in Preeclampsia
by: Ramana Vaka, et al.
Published: (2021-10-01)

Cell‐Free Mitochondrial DNA as a Potential Biomarker for Astronauts' Health
by: Malik Bisserier, et al.
Published: (2021-11-01)

Mitochondrial calcium uniporter MCU supports cytoplasmic Ca2+ oscillations, store-operated Ca2+ entry and Ca2+-dependent gene expression in response to receptor stimulation.
by: Krishna Samanta, et al.
Published: (2014-01-01)

Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons
by: Robert eNiescier, et al.
Published: (2013-09-01)

Mitochondrial Bioenergetics and Dynamism in the Failing Heart
by: Giampaolo Morciano, et al.
Published: (2021-05-01)

Mitochondrial Bioenergetics in Different Pathophysiological Conditions
by: Daniela Valenti, et al.
Published: (2021-07-01)

Tackling Dysfunction of Mitochondrial Bioenergetics in the Brain
by: Paola Zanfardino, et al.
Published: (2021-08-01)

Diet impact on Mitochondrial Bioenergetics and Dynamics
by: Rosalba ePutti, et al.
Published: (2015-04-01)

Bioenergetics Consequences of Mitochondrial Transplantation in Cardiomyocytes
by: Paria Ali Pour, et al.
Published: (2020-04-01)

The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter
by: Vivek Garg, et al.
Published: (2021-08-01)

Regulatory mechanisms of mitochondrial calcium uptake by the calcium uniporter complex
by: Akiko Yamada, et al.
Published: (2023-02-01)

Mitochondrial calcium uniporter involved in foodborne mycotoxin-induced hepatotoxicity
by: Shunwang Zhao, et al.
Published: (2022-06-01)

Mitochondrial Calcium Uniporter Deficiency in Zebrafish Causes Cardiomyopathy With Arrhythmia
by: Adam D. Langenbacher, et al.
Published: (2020-12-01)

The Mitochondrial Calcium Uniporter Controls Skeletal Muscle Trophism In Vivo
by: Cristina Mammucari, et al.
Published: (2015-03-01)

Carnitines as Mitochondrial Modulators of Oocyte and Embryo Bioenergetics
by: Martina Placidi, et al.
Published: (2022-04-01)

Mitochondrial Structure and Bioenergetics in Normal and Disease Conditions
by: Margherita Protasoni, et al.
Published: (2021-01-01)

Impaired Mitochondrial Bioenergetics under Pathological Conditions
by: Salvatore Nesci, et al.
Published: (2022-01-01)