Hydrodynamics and multiscale order in confluent epithelia
We formulate a hydrodynamic theory of confluent epithelia: i.e. monolayers of epithelial cells adhering to each other without gaps. Taking advantage of recent progresses toward establishing a general hydrodynamic theory of p-atic liquid crystals, we demonstrate that collectively migrating epithelia...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2024-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/86400 |
| _version_ | 1797245148584738816 |
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| author | Josep-Maria Armengol-Collado Livio Nicola Carenza Luca Giomi |
| author_facet | Josep-Maria Armengol-Collado Livio Nicola Carenza Luca Giomi |
| author_sort | Josep-Maria Armengol-Collado |
| collection | DOAJ |
| description | We formulate a hydrodynamic theory of confluent epithelia: i.e. monolayers of epithelial cells adhering to each other without gaps. Taking advantage of recent progresses toward establishing a general hydrodynamic theory of p-atic liquid crystals, we demonstrate that collectively migrating epithelia feature both nematic (i.e. p = 2) and hexatic (i.e. p = 6) orders, with the former being dominant at large and the latter at small length scales. Such a remarkable multiscale liquid crystal order leaves a distinct signature in the system’s structure factor, which exhibits two different power-law scaling regimes, reflecting both the hexagonal geometry of small cells clusters and the uniaxial structure of the global cellular flow. We support these analytical predictions with two different cell-resolved models of epithelia – i.e. the self-propelled Voronoi model and the multiphase field model – and highlight how momentum dissipation and noise influence the range of fluctuations at small length scales, thereby affecting the degree of cooperativity between cells. Our construction provides a theoretical framework to conceptualize the recent observation of multiscale order in layers of Madin–Darby canine kidney cells and pave the way for further theoretical developments. |
| first_indexed | 2024-04-24T19:22:18Z |
| format | Article |
| id | doaj.art-c11b7b228d644ebfa577ef2524274a38 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-24T19:22:18Z |
| publishDate | 2024-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-c11b7b228d644ebfa577ef2524274a382024-03-25T17:16:48ZengeLife Sciences Publications LtdeLife2050-084X2024-01-011310.7554/eLife.86400Hydrodynamics and multiscale order in confluent epitheliaJosep-Maria Armengol-Collado0https://orcid.org/0000-0003-0740-3040Livio Nicola Carenza1https://orcid.org/0000-0001-5996-331XLuca Giomi2https://orcid.org/0000-0001-7740-5960Instituut-Lorentz, Leiden University, Leiden, NetherlandsInstituut-Lorentz, Leiden University, Leiden, NetherlandsInstituut-Lorentz, Leiden University, Leiden, NetherlandsWe formulate a hydrodynamic theory of confluent epithelia: i.e. monolayers of epithelial cells adhering to each other without gaps. Taking advantage of recent progresses toward establishing a general hydrodynamic theory of p-atic liquid crystals, we demonstrate that collectively migrating epithelia feature both nematic (i.e. p = 2) and hexatic (i.e. p = 6) orders, with the former being dominant at large and the latter at small length scales. Such a remarkable multiscale liquid crystal order leaves a distinct signature in the system’s structure factor, which exhibits two different power-law scaling regimes, reflecting both the hexagonal geometry of small cells clusters and the uniaxial structure of the global cellular flow. We support these analytical predictions with two different cell-resolved models of epithelia – i.e. the self-propelled Voronoi model and the multiphase field model – and highlight how momentum dissipation and noise influence the range of fluctuations at small length scales, thereby affecting the degree of cooperativity between cells. Our construction provides a theoretical framework to conceptualize the recent observation of multiscale order in layers of Madin–Darby canine kidney cells and pave the way for further theoretical developments.https://elifesciences.org/articles/86400epithelialiquid crystalsmultiscalinghexaticnematic |
| spellingShingle | Josep-Maria Armengol-Collado Livio Nicola Carenza Luca Giomi Hydrodynamics and multiscale order in confluent epithelia eLife epithelia liquid crystals multiscaling hexatic nematic |
| title | Hydrodynamics and multiscale order in confluent epithelia |
| title_full | Hydrodynamics and multiscale order in confluent epithelia |
| title_fullStr | Hydrodynamics and multiscale order in confluent epithelia |
| title_full_unstemmed | Hydrodynamics and multiscale order in confluent epithelia |
| title_short | Hydrodynamics and multiscale order in confluent epithelia |
| title_sort | hydrodynamics and multiscale order in confluent epithelia |
| topic | epithelia liquid crystals multiscaling hexatic nematic |
| url | https://elifesciences.org/articles/86400 |
| work_keys_str_mv | AT josepmariaarmengolcollado hydrodynamicsandmultiscaleorderinconfluentepithelia AT livionicolacarenza hydrodynamicsandmultiscaleorderinconfluentepithelia AT lucagiomi hydrodynamicsandmultiscaleorderinconfluentepithelia |