Plasma clusterin (ApoJ) levels are associated with adiposity and systemic inflammation.
Obesity and insulin resistance are hallmarks of the metabolic syndrome, which is associated with low-grade chronic inflammation. Clusterin/apolipoprotein J is an abundant plasma chaperone protein that has recently been suggested as a potential biomarker that reflects the inflammatory process in Alzh...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4116172?pdf=render |
| _version_ | 1811281429243363328 |
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| author | Jong Chul Won Cheol-Young Park Sang Woo Oh Eon Sook Lee Byung-Soo Youn Min-Seon Kim |
| author_facet | Jong Chul Won Cheol-Young Park Sang Woo Oh Eon Sook Lee Byung-Soo Youn Min-Seon Kim |
| author_sort | Jong Chul Won |
| collection | DOAJ |
| description | Obesity and insulin resistance are hallmarks of the metabolic syndrome, which is associated with low-grade chronic inflammation. Clusterin/apolipoprotein J is an abundant plasma chaperone protein that has recently been suggested as a potential biomarker that reflects the inflammatory process in Alzheimer's disease. In the present study, we investigated anthropometric and clinical factors affecting the plasma levels of clusterin in healthy Korean subjects. We measured fasting plasma clusterin levels in healthy Korean adults (111 men and 93 women) using ELISA kit. We analyzed the relationship between plasma clusterin concentrations and anthropometric and clinical parameters. Fasting plasma clusterin concentrations were higher in overweight and obese subjects than in lean subjects. Correlation analysis revealed that the plasma clusterin levels were positively associated with indices of obesity such as body mass index (BMI), waist circumference and waist-hip ratio and markers of systemic inflammation such as high sensitivity C-reactive protein (hsCRP), uric acid, ferritin and retinol binding protein-4. Multiple linear regression analysis showed that sex, BMI and hsCRP were independent determinants of plasma clusterin levels. Furthermore, plasma clusterin levels showed an upward trend with increasing numbers of metabolic syndrome components. These findings suggest that fasting plasma clusterin levels correlate with the parameters of adiposity and systemic inflammation in healthy adults. Therefore, the circulating clusterin level may be a surrogate marker for obesity-associated systemic inflammation. |
| first_indexed | 2024-04-13T01:33:32Z |
| format | Article |
| id | doaj.art-c11b8ef49cb743a8889aca0cc088e713 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T01:33:32Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c11b8ef49cb743a8889aca0cc088e7132022-12-22T03:08:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10335110.1371/journal.pone.0103351Plasma clusterin (ApoJ) levels are associated with adiposity and systemic inflammation.Jong Chul WonCheol-Young ParkSang Woo OhEon Sook LeeByung-Soo YounMin-Seon KimObesity and insulin resistance are hallmarks of the metabolic syndrome, which is associated with low-grade chronic inflammation. Clusterin/apolipoprotein J is an abundant plasma chaperone protein that has recently been suggested as a potential biomarker that reflects the inflammatory process in Alzheimer's disease. In the present study, we investigated anthropometric and clinical factors affecting the plasma levels of clusterin in healthy Korean subjects. We measured fasting plasma clusterin levels in healthy Korean adults (111 men and 93 women) using ELISA kit. We analyzed the relationship between plasma clusterin concentrations and anthropometric and clinical parameters. Fasting plasma clusterin concentrations were higher in overweight and obese subjects than in lean subjects. Correlation analysis revealed that the plasma clusterin levels were positively associated with indices of obesity such as body mass index (BMI), waist circumference and waist-hip ratio and markers of systemic inflammation such as high sensitivity C-reactive protein (hsCRP), uric acid, ferritin and retinol binding protein-4. Multiple linear regression analysis showed that sex, BMI and hsCRP were independent determinants of plasma clusterin levels. Furthermore, plasma clusterin levels showed an upward trend with increasing numbers of metabolic syndrome components. These findings suggest that fasting plasma clusterin levels correlate with the parameters of adiposity and systemic inflammation in healthy adults. Therefore, the circulating clusterin level may be a surrogate marker for obesity-associated systemic inflammation.http://europepmc.org/articles/PMC4116172?pdf=render |
| spellingShingle | Jong Chul Won Cheol-Young Park Sang Woo Oh Eon Sook Lee Byung-Soo Youn Min-Seon Kim Plasma clusterin (ApoJ) levels are associated with adiposity and systemic inflammation. PLoS ONE |
| title | Plasma clusterin (ApoJ) levels are associated with adiposity and systemic inflammation. |
| title_full | Plasma clusterin (ApoJ) levels are associated with adiposity and systemic inflammation. |
| title_fullStr | Plasma clusterin (ApoJ) levels are associated with adiposity and systemic inflammation. |
| title_full_unstemmed | Plasma clusterin (ApoJ) levels are associated with adiposity and systemic inflammation. |
| title_short | Plasma clusterin (ApoJ) levels are associated with adiposity and systemic inflammation. |
| title_sort | plasma clusterin apoj levels are associated with adiposity and systemic inflammation |
| url | http://europepmc.org/articles/PMC4116172?pdf=render |
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