Correlation of hepatic transient elastography measurements and abdominal adiposity in children: A cross-sectional study
Background: Transient elastography is a non-invasive assessment of steatosis (measured as the controlled attenuation parameter, [CAP]) and fibrosis (measured as liver stiffness measurement, [LSM]) in patients with pediatric non-alcoholic fatty liver disease (NAFLD). Abdominal adiposity is considered...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957223000633 |
| _version_ | 1797526276245815296 |
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| author | Yii-Shiuan Lee Shih-Hsi Song Tzee-Chung Wu Shang-Liang Wu Ching-Feng Huang |
| author_facet | Yii-Shiuan Lee Shih-Hsi Song Tzee-Chung Wu Shang-Liang Wu Ching-Feng Huang |
| author_sort | Yii-Shiuan Lee |
| collection | DOAJ |
| description | Background: Transient elastography is a non-invasive assessment of steatosis (measured as the controlled attenuation parameter, [CAP]) and fibrosis (measured as liver stiffness measurement, [LSM]) in patients with pediatric non-alcoholic fatty liver disease (NAFLD). Abdominal adiposity is considered the most important factor for metabolic dysregulation including NAFLD. However, there is lack of a correlation between transient elastography measurements and abdominal adiposity. Accordingly, this study aimed to assess the correlation between transient elastography measurements and abdominal adiposity in children. Methods: This cross-sectional study included 137 children who visited the Taipei Veterans General Hospital. Hepatic steatosis (CAP) and fibrosis (LSM), were assessed by transient elastography. Abdominal adiposity including subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and preperitoneal adipose tissue (PPT) was assessed using abdominal sonography. The correlation between transient elastography measurements and abdominal adiposity was assessed using multiple linear regression. Results: In total, 137 children were included in this study. SAT and VAT were significantly associated with CAP, whereas SAT was significantly associated with LSM. An increment of 1 mm in SAT increased CAP and LSM by 5.56 dB/m and 0.06 kPa, respectively. Conclusion: Certain abdominal adiposities, especially SAT, are significantly associated with CAP and LSM, as determined by transient elastography. Simple abdominal adiposity measured using sonography may be useful for the early detection of pediatric NAFLD. |
| first_indexed | 2024-03-10T09:26:56Z |
| format | Article |
| id | doaj.art-c11c22e7cb694db9b619a0d86e3a907b |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-03-10T09:26:56Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-c11c22e7cb694db9b619a0d86e3a907b2023-11-22T04:46:57ZengElsevierPediatrics and Neonatology1875-95722023-11-01646631636Correlation of hepatic transient elastography measurements and abdominal adiposity in children: A cross-sectional studyYii-Shiuan Lee0Shih-Hsi Song1Tzee-Chung Wu2Shang-Liang Wu3Ching-Feng Huang4Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Pediatrics, National Yang Ming Chiao Tung University Hospital, Yilan, TaiwanDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, TaiwanDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan; Corresponding author. Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 112, Taiwan.Background: Transient elastography is a non-invasive assessment of steatosis (measured as the controlled attenuation parameter, [CAP]) and fibrosis (measured as liver stiffness measurement, [LSM]) in patients with pediatric non-alcoholic fatty liver disease (NAFLD). Abdominal adiposity is considered the most important factor for metabolic dysregulation including NAFLD. However, there is lack of a correlation between transient elastography measurements and abdominal adiposity. Accordingly, this study aimed to assess the correlation between transient elastography measurements and abdominal adiposity in children. Methods: This cross-sectional study included 137 children who visited the Taipei Veterans General Hospital. Hepatic steatosis (CAP) and fibrosis (LSM), were assessed by transient elastography. Abdominal adiposity including subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and preperitoneal adipose tissue (PPT) was assessed using abdominal sonography. The correlation between transient elastography measurements and abdominal adiposity was assessed using multiple linear regression. Results: In total, 137 children were included in this study. SAT and VAT were significantly associated with CAP, whereas SAT was significantly associated with LSM. An increment of 1 mm in SAT increased CAP and LSM by 5.56 dB/m and 0.06 kPa, respectively. Conclusion: Certain abdominal adiposities, especially SAT, are significantly associated with CAP and LSM, as determined by transient elastography. Simple abdominal adiposity measured using sonography may be useful for the early detection of pediatric NAFLD.http://www.sciencedirect.com/science/article/pii/S1875957223000633AbdomenChildElasticity imaging techniquesNon-alcoholic fatty liver disease |
| spellingShingle | Yii-Shiuan Lee Shih-Hsi Song Tzee-Chung Wu Shang-Liang Wu Ching-Feng Huang Correlation of hepatic transient elastography measurements and abdominal adiposity in children: A cross-sectional study Pediatrics and Neonatology Abdomen Child Elasticity imaging techniques Non-alcoholic fatty liver disease |
| title | Correlation of hepatic transient elastography measurements and abdominal adiposity in children: A cross-sectional study |
| title_full | Correlation of hepatic transient elastography measurements and abdominal adiposity in children: A cross-sectional study |
| title_fullStr | Correlation of hepatic transient elastography measurements and abdominal adiposity in children: A cross-sectional study |
| title_full_unstemmed | Correlation of hepatic transient elastography measurements and abdominal adiposity in children: A cross-sectional study |
| title_short | Correlation of hepatic transient elastography measurements and abdominal adiposity in children: A cross-sectional study |
| title_sort | correlation of hepatic transient elastography measurements and abdominal adiposity in children a cross sectional study |
| topic | Abdomen Child Elasticity imaging techniques Non-alcoholic fatty liver disease |
| url | http://www.sciencedirect.com/science/article/pii/S1875957223000633 |
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