Canine Parvovirus and Its Non-Structural Gene 1 as Oncolytic Agents: Mechanism of Action and Induction of Anti-Tumor Immune Response
The exploration into the strategies for the prevention and treatment of cancer is far from complete. Apart from humans, cancer has gained considerable importance in animals because of increased awareness towards animal health and welfare. Current cancer treatment regimens are less specific towards t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.648873/full |
| _version_ | 1818643252088143872 |
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| author | Richa Arora Waseem Akram Malla Arpit Tyagi Sonalika Mahajan Basavaraj Sajjanar Ashok Kumar Tiwari Ashok Kumar Tiwari |
| author_facet | Richa Arora Waseem Akram Malla Arpit Tyagi Sonalika Mahajan Basavaraj Sajjanar Ashok Kumar Tiwari Ashok Kumar Tiwari |
| author_sort | Richa Arora |
| collection | DOAJ |
| description | The exploration into the strategies for the prevention and treatment of cancer is far from complete. Apart from humans, cancer has gained considerable importance in animals because of increased awareness towards animal health and welfare. Current cancer treatment regimens are less specific towards tumor cells and end up harming normal healthy cells. Thus, a highly specific therapeutic strategy with minimal side effects is the need of the hour. Oncolytic viral gene therapy is one such specific approach to target cancer cells without affecting the normal cells of the body. Canine parvovirus (CPV) is an oncolytic virus that specifically targets and kills cancer cells by causing DNA damage, caspase activation, and mitochondrial damage. Non-structural gene 1 (NS1) of CPV, involved in viral DNA replication is a key mediator of cytotoxicity of CPV and can selectively cause tumor cell lysis. In this review, we discuss the oncolytic properties of Canine Parvovirus (CPV or CPV2), the structure of the NS1 protein, the mechanism of oncolytic action as well as role in inducing an antitumor immune response in different tumor models. |
| first_indexed | 2024-12-16T23:56:00Z |
| format | Article |
| id | doaj.art-c11d7d6b81224ff6829c8288a1bbf622 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-16T23:56:00Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c11d7d6b81224ff6829c8288a1bbf6222022-12-21T22:11:13ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-05-011110.3389/fonc.2021.648873648873Canine Parvovirus and Its Non-Structural Gene 1 as Oncolytic Agents: Mechanism of Action and Induction of Anti-Tumor Immune ResponseRicha Arora0Waseem Akram Malla1Arpit Tyagi2Sonalika Mahajan3Basavaraj Sajjanar4Ashok Kumar Tiwari5Ashok Kumar Tiwari6Division of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute, Izatnagar, IndiaDivision of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute, Izatnagar, IndiaGB Pant University of Agriculture and Technology, Pantnagar, IndiaDivision of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute, Izatnagar, IndiaDivision of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute, Izatnagar, IndiaDivision of Biological Standardisation, ICAR-Indian Veterinary Research Institute, Izatnagar, IndiaICAR - Central Avian Research Institute, Izatnagar, IndiaThe exploration into the strategies for the prevention and treatment of cancer is far from complete. Apart from humans, cancer has gained considerable importance in animals because of increased awareness towards animal health and welfare. Current cancer treatment regimens are less specific towards tumor cells and end up harming normal healthy cells. Thus, a highly specific therapeutic strategy with minimal side effects is the need of the hour. Oncolytic viral gene therapy is one such specific approach to target cancer cells without affecting the normal cells of the body. Canine parvovirus (CPV) is an oncolytic virus that specifically targets and kills cancer cells by causing DNA damage, caspase activation, and mitochondrial damage. Non-structural gene 1 (NS1) of CPV, involved in viral DNA replication is a key mediator of cytotoxicity of CPV and can selectively cause tumor cell lysis. In this review, we discuss the oncolytic properties of Canine Parvovirus (CPV or CPV2), the structure of the NS1 protein, the mechanism of oncolytic action as well as role in inducing an antitumor immune response in different tumor models.https://www.frontiersin.org/articles/10.3389/fonc.2021.648873/fulloncolytic virotherapyapoptosiscanine parvovirusnonstructural gene 1anti-cancer agent |
| spellingShingle | Richa Arora Waseem Akram Malla Arpit Tyagi Sonalika Mahajan Basavaraj Sajjanar Ashok Kumar Tiwari Ashok Kumar Tiwari Canine Parvovirus and Its Non-Structural Gene 1 as Oncolytic Agents: Mechanism of Action and Induction of Anti-Tumor Immune Response Frontiers in Oncology oncolytic virotherapy apoptosis canine parvovirus nonstructural gene 1 anti-cancer agent |
| title | Canine Parvovirus and Its Non-Structural Gene 1 as Oncolytic Agents: Mechanism of Action and Induction of Anti-Tumor Immune Response |
| title_full | Canine Parvovirus and Its Non-Structural Gene 1 as Oncolytic Agents: Mechanism of Action and Induction of Anti-Tumor Immune Response |
| title_fullStr | Canine Parvovirus and Its Non-Structural Gene 1 as Oncolytic Agents: Mechanism of Action and Induction of Anti-Tumor Immune Response |
| title_full_unstemmed | Canine Parvovirus and Its Non-Structural Gene 1 as Oncolytic Agents: Mechanism of Action and Induction of Anti-Tumor Immune Response |
| title_short | Canine Parvovirus and Its Non-Structural Gene 1 as Oncolytic Agents: Mechanism of Action and Induction of Anti-Tumor Immune Response |
| title_sort | canine parvovirus and its non structural gene 1 as oncolytic agents mechanism of action and induction of anti tumor immune response |
| topic | oncolytic virotherapy apoptosis canine parvovirus nonstructural gene 1 anti-cancer agent |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.648873/full |
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