Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis

Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis

Abstract Background Accumulating evidence has demonstrated that aberrant expression of deubiquitinating enzymes is associated with the initiation and progression of Triple-negative breast cancer (TNBC). The publicly available TCGA database of breast cancer data was used to analyze the OTUD deubiquit...

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Bibliographic Details
Main Authors: Zhitao Han, Qi Jia, Jing Zhang, Miaomiao Chen, Lining Wang, Kai Tong, Weiwei He, Yajie Zhang, Weina Zhu, Ju Qin, Tao Wang, Tielong Liu, Yong Ma, Yuanming Chen, Siluo Zha, Chunlei Zhang
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Triple-negative breast cancer (TNBC)
YOD1
CDK1
Ovarian tumor deubiquitinase
Ubiquitylation regulation
Online Access:https://doi.org/10.1186/s13046-023-02781-3

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