The Extracellular Matrix in Skin Inflammation and Infection
The extracellular matrix (ECM) is an integral component of all organs and plays a pivotal role in tissue homeostasis and repair. While the ECM was long thought to mostly have passive functions by providing physical stability to tissues, detailed characterization of its physical structure and biochem...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.682414/full |
| _version_ | 1819082117596839936 |
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| author | Karin Pfisterer Lisa E. Shaw Dörte Symmank Wolfgang Weninger |
| author_facet | Karin Pfisterer Lisa E. Shaw Dörte Symmank Wolfgang Weninger |
| author_sort | Karin Pfisterer |
| collection | DOAJ |
| description | The extracellular matrix (ECM) is an integral component of all organs and plays a pivotal role in tissue homeostasis and repair. While the ECM was long thought to mostly have passive functions by providing physical stability to tissues, detailed characterization of its physical structure and biochemical properties have uncovered an unprecedented broad spectrum of functions. It is now clear that the ECM not only comprises the essential building block of tissues but also actively supports and maintains the dynamic interplay between tissue compartments as well as embedded resident and recruited inflammatory cells in response to pathologic stimuli. On the other hand, certain pathogens such as bacteria and viruses have evolved strategies that exploit ECM structures for infection of cells and tissues, and mutations in ECM proteins can give rise to a variety of genetic conditions. Here, we review the composition, structure and function of the ECM in cutaneous homeostasis, inflammatory skin diseases such as psoriasis and atopic dermatitis as well as infections as a paradigm for understanding its wider role in human health. |
| first_indexed | 2024-12-21T20:11:34Z |
| format | Article |
| id | doaj.art-c1206e50726f428e92405b09c51e4457 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-21T20:11:34Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-c1206e50726f428e92405b09c51e44572022-12-21T18:51:44ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-07-01910.3389/fcell.2021.682414682414The Extracellular Matrix in Skin Inflammation and InfectionKarin PfistererLisa E. ShawDörte SymmankWolfgang WeningerThe extracellular matrix (ECM) is an integral component of all organs and plays a pivotal role in tissue homeostasis and repair. While the ECM was long thought to mostly have passive functions by providing physical stability to tissues, detailed characterization of its physical structure and biochemical properties have uncovered an unprecedented broad spectrum of functions. It is now clear that the ECM not only comprises the essential building block of tissues but also actively supports and maintains the dynamic interplay between tissue compartments as well as embedded resident and recruited inflammatory cells in response to pathologic stimuli. On the other hand, certain pathogens such as bacteria and viruses have evolved strategies that exploit ECM structures for infection of cells and tissues, and mutations in ECM proteins can give rise to a variety of genetic conditions. Here, we review the composition, structure and function of the ECM in cutaneous homeostasis, inflammatory skin diseases such as psoriasis and atopic dermatitis as well as infections as a paradigm for understanding its wider role in human health.https://www.frontiersin.org/articles/10.3389/fcell.2021.682414/fullextracellular matrix (ECM)cell migrationinflammationinfectiontissue homeostasisskin |
| spellingShingle | Karin Pfisterer Lisa E. Shaw Dörte Symmank Wolfgang Weninger The Extracellular Matrix in Skin Inflammation and Infection Frontiers in Cell and Developmental Biology extracellular matrix (ECM) cell migration inflammation infection tissue homeostasis skin |
| title | The Extracellular Matrix in Skin Inflammation and Infection |
| title_full | The Extracellular Matrix in Skin Inflammation and Infection |
| title_fullStr | The Extracellular Matrix in Skin Inflammation and Infection |
| title_full_unstemmed | The Extracellular Matrix in Skin Inflammation and Infection |
| title_short | The Extracellular Matrix in Skin Inflammation and Infection |
| title_sort | extracellular matrix in skin inflammation and infection |
| topic | extracellular matrix (ECM) cell migration inflammation infection tissue homeostasis skin |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.682414/full |
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