Polymorphism of genes that characterize the functional state of the vascular wall in newborns born to mothers with preeclampsia
The features of polymorphism of genes characterizing the functional state of the vascular wall in newborns born to mothers with preeclampsia were studied. 150 children were examined, the main group consisted of 100 newborns born to mothers with preeclampsia (PE), the control group included 50 childr...
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2022-09-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/1673 |
| _version_ | 1797875058814746624 |
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| author | I. G. Popova I. N. Fetisova S. Yu. Ratnikova S. B. Nazarov N. V. Кharlamova |
| author_facet | I. G. Popova I. N. Fetisova S. Yu. Ratnikova S. B. Nazarov N. V. Кharlamova |
| author_sort | I. G. Popova |
| collection | DOAJ |
| description | The features of polymorphism of genes characterizing the functional state of the vascular wall in newborns born to mothers with preeclampsia were studied. 150 children were examined, the main group consisted of 100 newborns born to mothers with preeclampsia (PE), the control group included 50 children born to women without preeclampsia. Single-nucleotide polymorphisms were determined in the blood of newborns: ADD1 G1378T (rs4961), AGT T704C (rs699), AGT C521T (rs4762), AGTR1 A1166C (rs5186), AGTR2 G1675A (rs1403543), CYP11B2 –344 C/T (rs1799998), GNB3 C825T (rs5443), NOS3 –786 T/C (rs2070744), NOS3 G894T (rs1799983) using the real-time polymerase chain reaction method with the DTprime 5 device (DNA-Technology, Russia) and the Cardiogenetics kit (DNA-Technology, Russia). The genetic analysis revealed that newborns born to mothers with PE were significantly more likely to have unfavorable genotypes АDD1 1378 G/T, AGT 704 T/C, AGT 704 C/C, AGTR2 1675 A/A, NOS3 (-786) C/C, NOS3 894T/T and alleles АDD1 1378T, AGT 704 C, AGTR2 1675A, NOS3 (-786) C, NOS3 894T. In newborns from mothers without PE, genotypes homozygous for the “wild type” alleles were significantly more common: АDD1 1378 G/G, AGT 704 T/T, CYP11B2 (-344) C/C, NOS3 (-786) T/T, NOS3 894 G/G and the NOS3 (-786) T allele. The revealed changes in newborns born to mothers with PE indicate an increased risk of developing disorders of the cardiovascular system. |
| first_indexed | 2024-04-10T01:41:42Z |
| format | Article |
| id | doaj.art-c120a4ec5d144cdd93a9e23f0f7d5185 |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:41:42Z |
| publishDate | 2022-09-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-c120a4ec5d144cdd93a9e23f0f7d51852023-03-13T09:12:53ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282022-09-01674394510.21508/1027-4065-2022-67-4-39-451217Polymorphism of genes that characterize the functional state of the vascular wall in newborns born to mothers with preeclampsiaI. G. Popova0I. N. Fetisova1S. Yu. Ratnikova2S. B. Nazarov3N. V. Кharlamova4ФГБУ «Ивановский научно-исследовательский институт материнства и детства им. В.Н. Городкова» Минздрава РоссииФГБУ «Ивановский научно-исследовательский институт материнства и детства им. В.Н. Городкова» Минздрава России; ФГБОУ ВО «Ивановская государственная медицинская академия» Минздрава РоссииФГБУ «Ивановский научно-исследовательский институт материнства и детства им. В.Н. Городкова» Минздрава РоссииФГБУ «Ивановский научно-исследовательский институт материнства и детства им. В.Н. Городкова» Минздрава России; ФГБОУ ВО «Ивановская государственная медицинская академия» Минздрава РоссииФГБУ «Ивановский научно-исследовательский институт материнства и детства им. В.Н. Городкова» Минздрава РоссииThe features of polymorphism of genes characterizing the functional state of the vascular wall in newborns born to mothers with preeclampsia were studied. 150 children were examined, the main group consisted of 100 newborns born to mothers with preeclampsia (PE), the control group included 50 children born to women without preeclampsia. Single-nucleotide polymorphisms were determined in the blood of newborns: ADD1 G1378T (rs4961), AGT T704C (rs699), AGT C521T (rs4762), AGTR1 A1166C (rs5186), AGTR2 G1675A (rs1403543), CYP11B2 –344 C/T (rs1799998), GNB3 C825T (rs5443), NOS3 –786 T/C (rs2070744), NOS3 G894T (rs1799983) using the real-time polymerase chain reaction method with the DTprime 5 device (DNA-Technology, Russia) and the Cardiogenetics kit (DNA-Technology, Russia). The genetic analysis revealed that newborns born to mothers with PE were significantly more likely to have unfavorable genotypes АDD1 1378 G/T, AGT 704 T/C, AGT 704 C/C, AGTR2 1675 A/A, NOS3 (-786) C/C, NOS3 894T/T and alleles АDD1 1378T, AGT 704 C, AGTR2 1675A, NOS3 (-786) C, NOS3 894T. In newborns from mothers without PE, genotypes homozygous for the “wild type” alleles were significantly more common: АDD1 1378 G/G, AGT 704 T/T, CYP11B2 (-344) C/C, NOS3 (-786) T/T, NOS3 894 G/G and the NOS3 (-786) T allele. The revealed changes in newborns born to mothers with PE indicate an increased risk of developing disorders of the cardiovascular system.https://www.ped-perinatology.ru/jour/article/view/1673новорожденныепреэклампсияполиморфизм геновсосудистая стенка |
| spellingShingle | I. G. Popova I. N. Fetisova S. Yu. Ratnikova S. B. Nazarov N. V. Кharlamova Polymorphism of genes that characterize the functional state of the vascular wall in newborns born to mothers with preeclampsia Rossijskij Vestnik Perinatologii i Pediatrii новорожденные преэклампсия полиморфизм генов сосудистая стенка |
| title | Polymorphism of genes that characterize the functional state of the vascular wall in newborns born to mothers with preeclampsia |
| title_full | Polymorphism of genes that characterize the functional state of the vascular wall in newborns born to mothers with preeclampsia |
| title_fullStr | Polymorphism of genes that characterize the functional state of the vascular wall in newborns born to mothers with preeclampsia |
| title_full_unstemmed | Polymorphism of genes that characterize the functional state of the vascular wall in newborns born to mothers with preeclampsia |
| title_short | Polymorphism of genes that characterize the functional state of the vascular wall in newborns born to mothers with preeclampsia |
| title_sort | polymorphism of genes that characterize the functional state of the vascular wall in newborns born to mothers with preeclampsia |
| topic | новорожденные преэклампсия полиморфизм генов сосудистая стенка |
| url | https://www.ped-perinatology.ru/jour/article/view/1673 |
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