Architecture of the SARS-CoV-2-specific T cell repertoire

The T cell response plays an indispensable role in the early control and successful clearance of SARS-CoV-2 infection. However, several important questions remain about the role of cellular immunity in COVID-19, including the shape and composition of disease-specific T cell repertoires across conval...

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Main Authors: Ksenia V. Zornikova, Saveliy A. Sheetikov, Alexander Yu Rusinov, Rustam N. Iskhakov, Apollinariya V. Bogolyubova
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1070077/full
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author Ksenia V. Zornikova
Saveliy A. Sheetikov
Saveliy A. Sheetikov
Alexander Yu Rusinov
Alexander Yu Rusinov
Rustam N. Iskhakov
Rustam N. Iskhakov
Apollinariya V. Bogolyubova
author_facet Ksenia V. Zornikova
Saveliy A. Sheetikov
Saveliy A. Sheetikov
Alexander Yu Rusinov
Alexander Yu Rusinov
Rustam N. Iskhakov
Rustam N. Iskhakov
Apollinariya V. Bogolyubova
author_sort Ksenia V. Zornikova
collection DOAJ
description The T cell response plays an indispensable role in the early control and successful clearance of SARS-CoV-2 infection. However, several important questions remain about the role of cellular immunity in COVID-19, including the shape and composition of disease-specific T cell repertoires across convalescent patients and vaccinated individuals, and how pre-existing T cell responses to other pathogens—in particular, common cold coronaviruses—impact susceptibility to SARS-CoV-2 infection and the subsequent course of disease. This review focuses on how the repertoire of T cell receptors (TCR) is shaped by natural infection and vaccination over time. We also summarize current knowledge regarding cross-reactive T cell responses and their protective role, and examine the implications of TCR repertoire diversity and cross-reactivity with regard to the design of vaccines that confer broader protection against SARS-CoV-2 variants.
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spelling doaj.art-c121149d18304dcba7cea1e3696c61ab2023-03-20T05:25:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.10700771070077Architecture of the SARS-CoV-2-specific T cell repertoireKsenia V. Zornikova0Saveliy A. Sheetikov1Saveliy A. Sheetikov2Alexander Yu Rusinov3Alexander Yu Rusinov4Rustam N. Iskhakov5Rustam N. Iskhakov6Apollinariya V. Bogolyubova7Laboratory of Transplantation Immunology, National Medical Research Center for Hematology, Moscow, RussiaLaboratory of Transplantation Immunology, National Medical Research Center for Hematology, Moscow, RussiaFaculty of Biology, Lomonosov Moscow State University, Moscow, RussiaLaboratory of Transplantation Immunology, National Medical Research Center for Hematology, Moscow, RussiaFaculty of Biology, Lomonosov Moscow State University, Moscow, RussiaLaboratory of Transplantation Immunology, National Medical Research Center for Hematology, Moscow, RussiaFaculty of Biology, Lomonosov Moscow State University, Moscow, RussiaLaboratory of Transplantation Immunology, National Medical Research Center for Hematology, Moscow, RussiaThe T cell response plays an indispensable role in the early control and successful clearance of SARS-CoV-2 infection. However, several important questions remain about the role of cellular immunity in COVID-19, including the shape and composition of disease-specific T cell repertoires across convalescent patients and vaccinated individuals, and how pre-existing T cell responses to other pathogens—in particular, common cold coronaviruses—impact susceptibility to SARS-CoV-2 infection and the subsequent course of disease. This review focuses on how the repertoire of T cell receptors (TCR) is shaped by natural infection and vaccination over time. We also summarize current knowledge regarding cross-reactive T cell responses and their protective role, and examine the implications of TCR repertoire diversity and cross-reactivity with regard to the design of vaccines that confer broader protection against SARS-CoV-2 variants.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1070077/fullT cell receptorsT cell immune responseSARS-CoV-2T cell repertoireT cell repertoire dynamic
spellingShingle Ksenia V. Zornikova
Saveliy A. Sheetikov
Saveliy A. Sheetikov
Alexander Yu Rusinov
Alexander Yu Rusinov
Rustam N. Iskhakov
Rustam N. Iskhakov
Apollinariya V. Bogolyubova
Architecture of the SARS-CoV-2-specific T cell repertoire
Frontiers in Immunology
T cell receptors
T cell immune response
SARS-CoV-2
T cell repertoire
T cell repertoire dynamic
title Architecture of the SARS-CoV-2-specific T cell repertoire
title_full Architecture of the SARS-CoV-2-specific T cell repertoire
title_fullStr Architecture of the SARS-CoV-2-specific T cell repertoire
title_full_unstemmed Architecture of the SARS-CoV-2-specific T cell repertoire
title_short Architecture of the SARS-CoV-2-specific T cell repertoire
title_sort architecture of the sars cov 2 specific t cell repertoire
topic T cell receptors
T cell immune response
SARS-CoV-2
T cell repertoire
T cell repertoire dynamic
url https://www.frontiersin.org/articles/10.3389/fimmu.2023.1070077/full
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