Architecture of the SARS-CoV-2-specific T cell repertoire
The T cell response plays an indispensable role in the early control and successful clearance of SARS-CoV-2 infection. However, several important questions remain about the role of cellular immunity in COVID-19, including the shape and composition of disease-specific T cell repertoires across conval...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-03-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1070077/full |
_version_ | 1797867202512158720 |
---|---|
author | Ksenia V. Zornikova Saveliy A. Sheetikov Saveliy A. Sheetikov Alexander Yu Rusinov Alexander Yu Rusinov Rustam N. Iskhakov Rustam N. Iskhakov Apollinariya V. Bogolyubova |
author_facet | Ksenia V. Zornikova Saveliy A. Sheetikov Saveliy A. Sheetikov Alexander Yu Rusinov Alexander Yu Rusinov Rustam N. Iskhakov Rustam N. Iskhakov Apollinariya V. Bogolyubova |
author_sort | Ksenia V. Zornikova |
collection | DOAJ |
description | The T cell response plays an indispensable role in the early control and successful clearance of SARS-CoV-2 infection. However, several important questions remain about the role of cellular immunity in COVID-19, including the shape and composition of disease-specific T cell repertoires across convalescent patients and vaccinated individuals, and how pre-existing T cell responses to other pathogens—in particular, common cold coronaviruses—impact susceptibility to SARS-CoV-2 infection and the subsequent course of disease. This review focuses on how the repertoire of T cell receptors (TCR) is shaped by natural infection and vaccination over time. We also summarize current knowledge regarding cross-reactive T cell responses and their protective role, and examine the implications of TCR repertoire diversity and cross-reactivity with regard to the design of vaccines that confer broader protection against SARS-CoV-2 variants. |
first_indexed | 2024-04-09T23:37:37Z |
format | Article |
id | doaj.art-c121149d18304dcba7cea1e3696c61ab |
institution | Directory Open Access Journal |
issn | 1664-3224 |
language | English |
last_indexed | 2024-04-09T23:37:37Z |
publishDate | 2023-03-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Immunology |
spelling | doaj.art-c121149d18304dcba7cea1e3696c61ab2023-03-20T05:25:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.10700771070077Architecture of the SARS-CoV-2-specific T cell repertoireKsenia V. Zornikova0Saveliy A. Sheetikov1Saveliy A. Sheetikov2Alexander Yu Rusinov3Alexander Yu Rusinov4Rustam N. Iskhakov5Rustam N. Iskhakov6Apollinariya V. Bogolyubova7Laboratory of Transplantation Immunology, National Medical Research Center for Hematology, Moscow, RussiaLaboratory of Transplantation Immunology, National Medical Research Center for Hematology, Moscow, RussiaFaculty of Biology, Lomonosov Moscow State University, Moscow, RussiaLaboratory of Transplantation Immunology, National Medical Research Center for Hematology, Moscow, RussiaFaculty of Biology, Lomonosov Moscow State University, Moscow, RussiaLaboratory of Transplantation Immunology, National Medical Research Center for Hematology, Moscow, RussiaFaculty of Biology, Lomonosov Moscow State University, Moscow, RussiaLaboratory of Transplantation Immunology, National Medical Research Center for Hematology, Moscow, RussiaThe T cell response plays an indispensable role in the early control and successful clearance of SARS-CoV-2 infection. However, several important questions remain about the role of cellular immunity in COVID-19, including the shape and composition of disease-specific T cell repertoires across convalescent patients and vaccinated individuals, and how pre-existing T cell responses to other pathogens—in particular, common cold coronaviruses—impact susceptibility to SARS-CoV-2 infection and the subsequent course of disease. This review focuses on how the repertoire of T cell receptors (TCR) is shaped by natural infection and vaccination over time. We also summarize current knowledge regarding cross-reactive T cell responses and their protective role, and examine the implications of TCR repertoire diversity and cross-reactivity with regard to the design of vaccines that confer broader protection against SARS-CoV-2 variants.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1070077/fullT cell receptorsT cell immune responseSARS-CoV-2T cell repertoireT cell repertoire dynamic |
spellingShingle | Ksenia V. Zornikova Saveliy A. Sheetikov Saveliy A. Sheetikov Alexander Yu Rusinov Alexander Yu Rusinov Rustam N. Iskhakov Rustam N. Iskhakov Apollinariya V. Bogolyubova Architecture of the SARS-CoV-2-specific T cell repertoire Frontiers in Immunology T cell receptors T cell immune response SARS-CoV-2 T cell repertoire T cell repertoire dynamic |
title | Architecture of the SARS-CoV-2-specific T cell repertoire |
title_full | Architecture of the SARS-CoV-2-specific T cell repertoire |
title_fullStr | Architecture of the SARS-CoV-2-specific T cell repertoire |
title_full_unstemmed | Architecture of the SARS-CoV-2-specific T cell repertoire |
title_short | Architecture of the SARS-CoV-2-specific T cell repertoire |
title_sort | architecture of the sars cov 2 specific t cell repertoire |
topic | T cell receptors T cell immune response SARS-CoV-2 T cell repertoire T cell repertoire dynamic |
url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1070077/full |
work_keys_str_mv | AT kseniavzornikova architectureofthesarscov2specifictcellrepertoire AT saveliyasheetikov architectureofthesarscov2specifictcellrepertoire AT saveliyasheetikov architectureofthesarscov2specifictcellrepertoire AT alexanderyurusinov architectureofthesarscov2specifictcellrepertoire AT alexanderyurusinov architectureofthesarscov2specifictcellrepertoire AT rustamniskhakov architectureofthesarscov2specifictcellrepertoire AT rustamniskhakov architectureofthesarscov2specifictcellrepertoire AT apollinariyavbogolyubova architectureofthesarscov2specifictcellrepertoire |