Natural Products in Modulating Methamphetamine-Induced Neuronal Apoptosis
Methamphetamine (METH), an amphetamine-type psychostimulant, is highly abused worldwide. Chronic abuse of METH causes neurodegenerative changes in central dopaminergic neurons with numerous neuropsychiatric consequences. Neuronal apoptosis plays a critical role in METH-induced neurotoxicity and may...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.805991/full |
| _version_ | 1828123497111486464 |
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| author | Yiwei Zeng Yunhui Chen Su Zhang Huan Ren Jialin Xia Mengnan Liu Baozhi Shan Yulan Ren |
| author_facet | Yiwei Zeng Yunhui Chen Su Zhang Huan Ren Jialin Xia Mengnan Liu Baozhi Shan Yulan Ren |
| author_sort | Yiwei Zeng |
| collection | DOAJ |
| description | Methamphetamine (METH), an amphetamine-type psychostimulant, is highly abused worldwide. Chronic abuse of METH causes neurodegenerative changes in central dopaminergic neurons with numerous neuropsychiatric consequences. Neuronal apoptosis plays a critical role in METH-induced neurotoxicity and may provide promising pharmacological targets for preventing and treating METH addiction. In recent years, accumulating evidence has revealed that natural products may possess significant potentials to inhibit METH-evoked neuronal apoptosis. In this review, we summarized and analyzed the improvement effect of natural products on METH-induced neuronal apoptosis and their potential molecular mechanisms on modulating dopamine release, oxidative stress, mitochondrial-dependent apoptotic pathway, endoplasmic reticulum stress-mediated apoptotic pathway, and neuroinflammation. Hopefully, this review may highlight the potential value of natural products in modulating METH-caused neuronal apoptosis and provide useful information for future research and developments of novel and efficacious pharmacotherapies in this field. |
| first_indexed | 2024-04-11T14:52:04Z |
| format | Article |
| id | doaj.art-c121daceb824466fbdb3647b0ea9f95f |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T14:52:04Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-c121daceb824466fbdb3647b0ea9f95f2022-12-22T04:17:23ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-01-011210.3389/fphar.2021.805991805991Natural Products in Modulating Methamphetamine-Induced Neuronal ApoptosisYiwei Zeng0Yunhui Chen1Su Zhang2Huan Ren3Jialin Xia4Mengnan Liu5Baozhi Shan6Yulan Ren7College of Acupuncture-moxibustion and Tuina, College of Basic Medicine, College of Nursing, College of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCollege of Acupuncture-moxibustion and Tuina, College of Basic Medicine, College of Nursing, College of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCollege of Acupuncture-moxibustion and Tuina, College of Basic Medicine, College of Nursing, College of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCollege of Acupuncture-moxibustion and Tuina, College of Basic Medicine, College of Nursing, College of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCollege of Acupuncture-moxibustion and Tuina, College of Basic Medicine, College of Nursing, College of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaTraditional Chinese Medicine Hospital Affiliated to Southwest Medical University, Luzhou, ChinaSchool of Humanities, Jiangxi University of Traditional Chinese Medicine, Nanchang, ChinaCollege of Acupuncture-moxibustion and Tuina, College of Basic Medicine, College of Nursing, College of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaMethamphetamine (METH), an amphetamine-type psychostimulant, is highly abused worldwide. Chronic abuse of METH causes neurodegenerative changes in central dopaminergic neurons with numerous neuropsychiatric consequences. Neuronal apoptosis plays a critical role in METH-induced neurotoxicity and may provide promising pharmacological targets for preventing and treating METH addiction. In recent years, accumulating evidence has revealed that natural products may possess significant potentials to inhibit METH-evoked neuronal apoptosis. In this review, we summarized and analyzed the improvement effect of natural products on METH-induced neuronal apoptosis and their potential molecular mechanisms on modulating dopamine release, oxidative stress, mitochondrial-dependent apoptotic pathway, endoplasmic reticulum stress-mediated apoptotic pathway, and neuroinflammation. Hopefully, this review may highlight the potential value of natural products in modulating METH-caused neuronal apoptosis and provide useful information for future research and developments of novel and efficacious pharmacotherapies in this field.https://www.frontiersin.org/articles/10.3389/fphar.2021.805991/fullmethamphetaminedopaminergic neuronsapoptosisnatural productsneurodegenaration |
| spellingShingle | Yiwei Zeng Yunhui Chen Su Zhang Huan Ren Jialin Xia Mengnan Liu Baozhi Shan Yulan Ren Natural Products in Modulating Methamphetamine-Induced Neuronal Apoptosis Frontiers in Pharmacology methamphetamine dopaminergic neurons apoptosis natural products neurodegenaration |
| title | Natural Products in Modulating Methamphetamine-Induced Neuronal Apoptosis |
| title_full | Natural Products in Modulating Methamphetamine-Induced Neuronal Apoptosis |
| title_fullStr | Natural Products in Modulating Methamphetamine-Induced Neuronal Apoptosis |
| title_full_unstemmed | Natural Products in Modulating Methamphetamine-Induced Neuronal Apoptosis |
| title_short | Natural Products in Modulating Methamphetamine-Induced Neuronal Apoptosis |
| title_sort | natural products in modulating methamphetamine induced neuronal apoptosis |
| topic | methamphetamine dopaminergic neurons apoptosis natural products neurodegenaration |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.805991/full |
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