Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy
Abstract Emerging evidence indicates that cancer cells can mimic characteristics of embryonic development, promoting their development and progression. Cancer cells share features with embryonic development, characterized by robust proliferation and differentiation regulated by signaling pathways su...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
|
| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.427 |
| _version_ | 1797373566793023488 |
|---|---|
| author | Jiangjun Cao Zhe Zhang Li Zhou Maochao Luo Lei Li Bowen Li Edouard C. Nice Weifeng He Shaojiang Zheng Canhua Huang |
| author_facet | Jiangjun Cao Zhe Zhang Li Zhou Maochao Luo Lei Li Bowen Li Edouard C. Nice Weifeng He Shaojiang Zheng Canhua Huang |
| author_sort | Jiangjun Cao |
| collection | DOAJ |
| description | Abstract Emerging evidence indicates that cancer cells can mimic characteristics of embryonic development, promoting their development and progression. Cancer cells share features with embryonic development, characterized by robust proliferation and differentiation regulated by signaling pathways such as Wnt, Notch, hedgehog, and Hippo signaling. In certain phase, these cells also mimic embryonic diapause and fertilized egg implantation to evade treatments or immune elimination and promote metastasis. Additionally, the upregulation of ATP‐binding cassette (ABC) transporters, including multidrug resistance protein 1 (MDR1), multidrug resistance‐associated protein 1 (MRP1), and breast cancer‐resistant protein (BCRP), in drug‐resistant cancer cells, analogous to their role in placental development, may facilitate chemotherapy efflux, further resulting in treatment resistance. In this review, we concentrate on the underlying mechanisms that contribute to tumor development and progression from the perspective of embryonic development, encompassing the dysregulation of developmental signaling pathways, the emergence of dormant cancer cells, immune microenvironment remodeling, and the hyperactivation of ABC transporters. Furthermore, we synthesize and emphasize the connections between cancer hallmarks and embryonic development, offering novel insights for the development of innovative cancer treatment strategies. |
| first_indexed | 2024-03-08T18:52:21Z |
| format | Article |
| id | doaj.art-c122501db8aa4648bbe200960d25e642 |
| institution | Directory Open Access Journal |
| issn | 2688-2663 |
| language | English |
| last_indexed | 2024-03-08T18:52:21Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj.art-c122501db8aa4648bbe200960d25e6422023-12-28T16:52:34ZengWileyMedComm2688-26632023-12-0146n/an/a10.1002/mco2.427Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapyJiangjun Cao0Zhe Zhang1Li Zhou2Maochao Luo3Lei Li4Bowen Li5Edouard C. Nice6Weifeng He7Shaojiang Zheng8Canhua Huang9West China School of Basic Medical Sciences and Forensic Medicine, and Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China HospitalSichuan University Chengdu ChinaZhejiang Provincial Key Laboratory of Pancreatic Disease the First Affiliated Hospital School of Medicine Zhejiang University Zhejiang ChinaKey Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Department of Infectious Diseases the Second Affiliated Hospital Institute for Viral Hepatitis, Chongqing Medical University Chongqing ChinaWest China School of Basic Medical Sciences and Forensic Medicine, and Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China HospitalSichuan University Chengdu ChinaDepartment of anorectal surgery Hospital of Chengdu University of Traditional Chinese Medicine and Chengdu University of Traditional Chinese Medicine Chengdu ChinaWest China School of Basic Medical Sciences and Forensic Medicine, and Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China HospitalSichuan University Chengdu ChinaDepartment of Biochemistry and Molecular Biology Monash University Clayton VIC AustraliaState Key Laboratory of Trauma Burn and Combined Injury Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing ChinaHainan Cancer Medical Center of The First Affiliated Hospital, the Hainan Branch of National Clinical Research Center for Cancer, Hainan Engineering Research Center for Biological Sample Resources of Major Diseases Hainan Medical University Haikou ChinaWest China School of Basic Medical Sciences and Forensic Medicine, and Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China HospitalSichuan University Chengdu ChinaAbstract Emerging evidence indicates that cancer cells can mimic characteristics of embryonic development, promoting their development and progression. Cancer cells share features with embryonic development, characterized by robust proliferation and differentiation regulated by signaling pathways such as Wnt, Notch, hedgehog, and Hippo signaling. In certain phase, these cells also mimic embryonic diapause and fertilized egg implantation to evade treatments or immune elimination and promote metastasis. Additionally, the upregulation of ATP‐binding cassette (ABC) transporters, including multidrug resistance protein 1 (MDR1), multidrug resistance‐associated protein 1 (MRP1), and breast cancer‐resistant protein (BCRP), in drug‐resistant cancer cells, analogous to their role in placental development, may facilitate chemotherapy efflux, further resulting in treatment resistance. In this review, we concentrate on the underlying mechanisms that contribute to tumor development and progression from the perspective of embryonic development, encompassing the dysregulation of developmental signaling pathways, the emergence of dormant cancer cells, immune microenvironment remodeling, and the hyperactivation of ABC transporters. Furthermore, we synthesize and emphasize the connections between cancer hallmarks and embryonic development, offering novel insights for the development of innovative cancer treatment strategies.https://doi.org/10.1002/mco2.427cancer therapydrug resistanceembryonic developmenttumor development and progression |
| spellingShingle | Jiangjun Cao Zhe Zhang Li Zhou Maochao Luo Lei Li Bowen Li Edouard C. Nice Weifeng He Shaojiang Zheng Canhua Huang Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy MedComm cancer therapy drug resistance embryonic development tumor development and progression |
| title | Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy |
| title_full | Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy |
| title_fullStr | Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy |
| title_full_unstemmed | Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy |
| title_short | Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy |
| title_sort | oncofetal reprogramming in tumor development and progression novel insights into cancer therapy |
| topic | cancer therapy drug resistance embryonic development tumor development and progression |
| url | https://doi.org/10.1002/mco2.427 |
| work_keys_str_mv | AT jiangjuncao oncofetalreprogrammingintumordevelopmentandprogressionnovelinsightsintocancertherapy AT zhezhang oncofetalreprogrammingintumordevelopmentandprogressionnovelinsightsintocancertherapy AT lizhou oncofetalreprogrammingintumordevelopmentandprogressionnovelinsightsintocancertherapy AT maochaoluo oncofetalreprogrammingintumordevelopmentandprogressionnovelinsightsintocancertherapy AT leili oncofetalreprogrammingintumordevelopmentandprogressionnovelinsightsintocancertherapy AT bowenli oncofetalreprogrammingintumordevelopmentandprogressionnovelinsightsintocancertherapy AT edouardcnice oncofetalreprogrammingintumordevelopmentandprogressionnovelinsightsintocancertherapy AT weifenghe oncofetalreprogrammingintumordevelopmentandprogressionnovelinsightsintocancertherapy AT shaojiangzheng oncofetalreprogrammingintumordevelopmentandprogressionnovelinsightsintocancertherapy AT canhuahuang oncofetalreprogrammingintumordevelopmentandprogressionnovelinsightsintocancertherapy |