The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration
During heart failure, the heart is unable to regenerate lost or damaged cardiomyocytes and is therefore unable to generate adequate cardiac output. Previous research has demonstrated that cardiac regeneration can be promoted by a hypoxia-related oxygen metabolic mechanism. Numerous studies have indi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.664527/full |
| _version_ | 1831767913899491328 |
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| author | Bing Bo Bing Bo Shuangshuang Li Ke Zhou Ke Zhou Jianshe Wei |
| author_facet | Bing Bo Bing Bo Shuangshuang Li Ke Zhou Ke Zhou Jianshe Wei |
| author_sort | Bing Bo |
| collection | DOAJ |
| description | During heart failure, the heart is unable to regenerate lost or damaged cardiomyocytes and is therefore unable to generate adequate cardiac output. Previous research has demonstrated that cardiac regeneration can be promoted by a hypoxia-related oxygen metabolic mechanism. Numerous studies have indicated that exercise plays a regulatory role in the activation of regeneration capacity in both healthy and injured adult cardiomyocytes. However, the role of oxygen metabolism in regulating exercise-induced cardiomyocyte regeneration is unclear. This review focuses on the alteration of the oxygen environment and metabolism in the myocardium induced by exercise, including the effects of mild hypoxia, changes in energy metabolism, enhanced elimination of reactive oxygen species, augmentation of antioxidative capacity, and regulation of the oxygen-related metabolic and molecular pathway in the heart. Deciphering the regulatory role of oxygen metabolism and related factors during and after exercise in cardiomyocyte regeneration will provide biological insight into endogenous cardiac repair mechanisms. Furthermore, this work provides strong evidence for exercise as a cost-effective intervention to improve cardiomyocyte regeneration and restore cardiac function in this patient population. |
| first_indexed | 2024-12-22T06:51:11Z |
| format | Article |
| id | doaj.art-c1226fb42f2d40d19e0d80b51a598043 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-22T06:51:11Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-c1226fb42f2d40d19e0d80b51a5980432022-12-21T18:35:09ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-04-01910.3389/fcell.2021.664527664527The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte RegenerationBing Bo0Bing Bo1Shuangshuang Li2Ke Zhou3Ke Zhou4Jianshe Wei5Kinesiology Department, School of Physical Education, Henan University, Kaifeng, ChinaSports Reform and Development Research Center, School of Physical Education, Henan University, Kaifeng, ChinaKinesiology Department, School of Physical Education, Henan University, Kaifeng, ChinaKinesiology Department, School of Physical Education, Henan University, Kaifeng, ChinaSports Reform and Development Research Center, School of Physical Education, Henan University, Kaifeng, ChinaInstitute for Brain Sciences Research, School of Life Sciences, Henan University, Kaifeng, ChinaDuring heart failure, the heart is unable to regenerate lost or damaged cardiomyocytes and is therefore unable to generate adequate cardiac output. Previous research has demonstrated that cardiac regeneration can be promoted by a hypoxia-related oxygen metabolic mechanism. Numerous studies have indicated that exercise plays a regulatory role in the activation of regeneration capacity in both healthy and injured adult cardiomyocytes. However, the role of oxygen metabolism in regulating exercise-induced cardiomyocyte regeneration is unclear. This review focuses on the alteration of the oxygen environment and metabolism in the myocardium induced by exercise, including the effects of mild hypoxia, changes in energy metabolism, enhanced elimination of reactive oxygen species, augmentation of antioxidative capacity, and regulation of the oxygen-related metabolic and molecular pathway in the heart. Deciphering the regulatory role of oxygen metabolism and related factors during and after exercise in cardiomyocyte regeneration will provide biological insight into endogenous cardiac repair mechanisms. Furthermore, this work provides strong evidence for exercise as a cost-effective intervention to improve cardiomyocyte regeneration and restore cardiac function in this patient population.https://www.frontiersin.org/articles/10.3389/fcell.2021.664527/fullcardiomyocyte regenerationexerciseoxygen metabolismhypoxiamolecular pathway |
| spellingShingle | Bing Bo Bing Bo Shuangshuang Li Ke Zhou Ke Zhou Jianshe Wei The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration Frontiers in Cell and Developmental Biology cardiomyocyte regeneration exercise oxygen metabolism hypoxia molecular pathway |
| title | The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration |
| title_full | The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration |
| title_fullStr | The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration |
| title_full_unstemmed | The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration |
| title_short | The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration |
| title_sort | regulatory role of oxygen metabolism in exercise induced cardiomyocyte regeneration |
| topic | cardiomyocyte regeneration exercise oxygen metabolism hypoxia molecular pathway |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.664527/full |
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