Cellular and Intercellular Homeostasis in Adipose Tissue with Mitochondria-Specific Stress
Paracrine interactions are imperative for the maintenance of adipose tissue intercellular homeostasis, and intracellular organelle dysfunction results in local and systemic alterations in metabolic homeostasis. It is currently accepted that mitochondrial proteotoxic stress activates the mitochondria...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2021-02-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.e-enm.org/upload/pdf/enm-2021-956.pdf |
| _version_ | 1818754882266464256 |
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| author | Min Jeong Choi Saet-Byel Jung Joon Young Chang Minho Shong |
| author_facet | Min Jeong Choi Saet-Byel Jung Joon Young Chang Minho Shong |
| author_sort | Min Jeong Choi |
| collection | DOAJ |
| description | Paracrine interactions are imperative for the maintenance of adipose tissue intercellular homeostasis, and intracellular organelle dysfunction results in local and systemic alterations in metabolic homeostasis. It is currently accepted that mitochondrial proteotoxic stress activates the mitochondrial unfolded protein response (UPRmt) in vitro and in vivo. The induction of mitochondrial chaperones and proteases during the UPRmt is a key cell-autonomous mechanism of mitochondrial quality control. The UPRmt also affects systemic metabolism through the secretion of cell non-autonomous peptides and cytokines (hereafter, metabokines). Mitochondrial function in adipose tissue plays a pivotal role in whole-body metabolism and human diseases. Despite continuing interest in the role of the UPRmt and quality control pathways of mitochondria in energy metabolism, studies on the roles of the UPRmt and metabokines in white adipose tissue are relatively sparse. Here, we describe the role of the UPRmt in adipose tissue, including adipocytes and resident macrophages, and the interactive roles of cell non-autonomous metabokines, particularly growth differentiation factor 15, in local adipose cellular homeostasis and systemic energy metabolism. |
| first_indexed | 2024-12-18T05:30:19Z |
| format | Article |
| id | doaj.art-c124a7b98ac642fab4ad6ac11a78104f |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-18T05:30:19Z |
| publishDate | 2021-02-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-c124a7b98ac642fab4ad6ac11a78104f2022-12-21T21:19:28ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782021-02-0136111110.3803/EnM.2021.9562114Cellular and Intercellular Homeostasis in Adipose Tissue with Mitochondria-Specific StressMin Jeong Choi0Saet-Byel Jung1Joon Young Chang2Minho Shong3 Department of Medical Science, Chungnam National University College of Medicine, Daejeon, Korea Center for Biomolecular & Cellular Structure, Institute for Basic Science, Daejeon, Korea Department of Medical Science, Chungnam National University College of Medicine, Daejeon, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, KoreaParacrine interactions are imperative for the maintenance of adipose tissue intercellular homeostasis, and intracellular organelle dysfunction results in local and systemic alterations in metabolic homeostasis. It is currently accepted that mitochondrial proteotoxic stress activates the mitochondrial unfolded protein response (UPRmt) in vitro and in vivo. The induction of mitochondrial chaperones and proteases during the UPRmt is a key cell-autonomous mechanism of mitochondrial quality control. The UPRmt also affects systemic metabolism through the secretion of cell non-autonomous peptides and cytokines (hereafter, metabokines). Mitochondrial function in adipose tissue plays a pivotal role in whole-body metabolism and human diseases. Despite continuing interest in the role of the UPRmt and quality control pathways of mitochondria in energy metabolism, studies on the roles of the UPRmt and metabokines in white adipose tissue are relatively sparse. Here, we describe the role of the UPRmt in adipose tissue, including adipocytes and resident macrophages, and the interactive roles of cell non-autonomous metabokines, particularly growth differentiation factor 15, in local adipose cellular homeostasis and systemic energy metabolism.http://www.e-enm.org/upload/pdf/enm-2021-956.pdfadipocytesmitochondriamacrophagesenergy metabolismunfolded protein response |
| spellingShingle | Min Jeong Choi Saet-Byel Jung Joon Young Chang Minho Shong Cellular and Intercellular Homeostasis in Adipose Tissue with Mitochondria-Specific Stress Endocrinology and Metabolism adipocytes mitochondria macrophages energy metabolism unfolded protein response |
| title | Cellular and Intercellular Homeostasis in Adipose Tissue with Mitochondria-Specific Stress |
| title_full | Cellular and Intercellular Homeostasis in Adipose Tissue with Mitochondria-Specific Stress |
| title_fullStr | Cellular and Intercellular Homeostasis in Adipose Tissue with Mitochondria-Specific Stress |
| title_full_unstemmed | Cellular and Intercellular Homeostasis in Adipose Tissue with Mitochondria-Specific Stress |
| title_short | Cellular and Intercellular Homeostasis in Adipose Tissue with Mitochondria-Specific Stress |
| title_sort | cellular and intercellular homeostasis in adipose tissue with mitochondria specific stress |
| topic | adipocytes mitochondria macrophages energy metabolism unfolded protein response |
| url | http://www.e-enm.org/upload/pdf/enm-2021-956.pdf |
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