Inhibitory Properties of Aldehydes and Related Compounds against <i>Phytophthora infestans</i>—Identification of a New Lead
The pathogen <i>Phytophthora infestans</i> is responsible for catastrophic crop damage on a global scale which totals billions of euros annually. The discovery of new inhibitors of this organism is of paramount agricultural importance and of critical relevance to food security. Current s...
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| Format: | Article |
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MDPI AG
2020-07-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/7/542 |
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| author | John J. Mackrill Roberta A. Kehoe Limian Zheng Mary L. McKee Elaine C. O’Sullivan Barbara M. Doyle Prestwich Florence O. McCarthy |
| author_facet | John J. Mackrill Roberta A. Kehoe Limian Zheng Mary L. McKee Elaine C. O’Sullivan Barbara M. Doyle Prestwich Florence O. McCarthy |
| author_sort | John J. Mackrill |
| collection | DOAJ |
| description | The pathogen <i>Phytophthora infestans</i> is responsible for catastrophic crop damage on a global scale which totals billions of euros annually. The discovery of new inhibitors of this organism is of paramount agricultural importance and of critical relevance to food security. Current strategies for crop treatment are inadequate with the emergence of resistant strains and problematic toxicity. Natural products such as cinnamaldehyde have been reported to have fungicidal properties and are the seed for many new discovery research programmes. We report a probe of the cinnamaldehyde framework to investigate the aldehyde subunit and its role in a subset of aromatic aldehydes in order to identify new lead compounds to act against <i>P. infestans</i>. An ellipticine derivative which incorporates an aldehyde (9-formyl-6-methyl ellipticine, <b>34</b>) has been identified with exceptional activity versus <i>P. infestans</i> with limited toxicity and potential for use as a fungicide. |
| first_indexed | 2024-03-10T18:38:51Z |
| format | Article |
| id | doaj.art-c124e8835b8447d8a835b1b39a521b58 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T18:38:51Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-c124e8835b8447d8a835b1b39a521b582023-11-20T06:02:02ZengMDPI AGPathogens2076-08172020-07-019754210.3390/pathogens9070542Inhibitory Properties of Aldehydes and Related Compounds against <i>Phytophthora infestans</i>—Identification of a New LeadJohn J. Mackrill0Roberta A. Kehoe1Limian Zheng2Mary L. McKee3Elaine C. O’Sullivan4Barbara M. Doyle Prestwich5Florence O. McCarthy6Department of Physiology, School of Medicine, University College Cork, T12 K8AF Cork, IrelandSchool of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, IrelandDepartment of Physiology, School of Medicine, University College Cork, T12 K8AF Cork, IrelandSchool of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, IrelandSchool of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, IrelandSchool of Biological, Earth and Environmental Sciences, University College Cork, T12 K8AF Cork, IrelandSchool of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, IrelandThe pathogen <i>Phytophthora infestans</i> is responsible for catastrophic crop damage on a global scale which totals billions of euros annually. The discovery of new inhibitors of this organism is of paramount agricultural importance and of critical relevance to food security. Current strategies for crop treatment are inadequate with the emergence of resistant strains and problematic toxicity. Natural products such as cinnamaldehyde have been reported to have fungicidal properties and are the seed for many new discovery research programmes. We report a probe of the cinnamaldehyde framework to investigate the aldehyde subunit and its role in a subset of aromatic aldehydes in order to identify new lead compounds to act against <i>P. infestans</i>. An ellipticine derivative which incorporates an aldehyde (9-formyl-6-methyl ellipticine, <b>34</b>) has been identified with exceptional activity versus <i>P. infestans</i> with limited toxicity and potential for use as a fungicide.https://www.mdpi.com/2076-0817/9/7/542<i>Phytophthora infestans</i>cinnamaldehydethiosemicarbazoneellipticinefungicide |
| spellingShingle | John J. Mackrill Roberta A. Kehoe Limian Zheng Mary L. McKee Elaine C. O’Sullivan Barbara M. Doyle Prestwich Florence O. McCarthy Inhibitory Properties of Aldehydes and Related Compounds against <i>Phytophthora infestans</i>—Identification of a New Lead Pathogens <i>Phytophthora infestans</i> cinnamaldehyde thiosemicarbazone ellipticine fungicide |
| title | Inhibitory Properties of Aldehydes and Related Compounds against <i>Phytophthora infestans</i>—Identification of a New Lead |
| title_full | Inhibitory Properties of Aldehydes and Related Compounds against <i>Phytophthora infestans</i>—Identification of a New Lead |
| title_fullStr | Inhibitory Properties of Aldehydes and Related Compounds against <i>Phytophthora infestans</i>—Identification of a New Lead |
| title_full_unstemmed | Inhibitory Properties of Aldehydes and Related Compounds against <i>Phytophthora infestans</i>—Identification of a New Lead |
| title_short | Inhibitory Properties of Aldehydes and Related Compounds against <i>Phytophthora infestans</i>—Identification of a New Lead |
| title_sort | inhibitory properties of aldehydes and related compounds against i phytophthora infestans i identification of a new lead |
| topic | <i>Phytophthora infestans</i> cinnamaldehyde thiosemicarbazone ellipticine fungicide |
| url | https://www.mdpi.com/2076-0817/9/7/542 |
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