Distinct effector functions mediated by Fc regions of bovine IgG subclasses and their interaction with Fc gamma receptors

Distinct effector functions mediated by Fc regions of bovine IgG subclasses and their interaction with Fc gamma receptors

Cattle possess three IgG subclasses. However, the key immune functions, including complement and NK cell activation, and enhancement of phagocytosis, are not fully described for bovine IgG1, 2 and 3. We produced chimeric monoclonal antibodies (mAbs) consisting of a defined variable region linked to...

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Bibliographic Details
Main Authors: Alistair Noble, Basudev Paudyal, John C. Schwartz, William Mwangi, Danish Munir, Elma Tchilian, John A. Hammond, Simon P. Graham
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
cattle
IgG subclasses
Fc gamma receptor
Fc region
NK cell
monocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1286903/full

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