Association of umbilical cord insulin-like growth factor 1 levels with severe retinopathy in extremely preterm infants
Background: The association between umbilical cord blood insulin-like growth factor 1 (IGF-1) levels and retinopathy of prematurity (ROP) remains unclear. This study aimed to investigate whether umbilical cord blood IGF-1 levels can predict the development of severe ROP in extremely preterm infants....
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Pediatrics and Neonatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957222002017 |
| _version_ | 1797857709773553664 |
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| author | Nobuhiko Nagano Daichi Katayama Koichiro Hara Takuya Akimoto Takayuki Imaizumi Ayako Seimiya Ryoji Aoki Midori Hijikata Kazumasa Fuwa Aya Okahashi Ichiro Morioka |
| author_facet | Nobuhiko Nagano Daichi Katayama Koichiro Hara Takuya Akimoto Takayuki Imaizumi Ayako Seimiya Ryoji Aoki Midori Hijikata Kazumasa Fuwa Aya Okahashi Ichiro Morioka |
| author_sort | Nobuhiko Nagano |
| collection | DOAJ |
| description | Background: The association between umbilical cord blood insulin-like growth factor 1 (IGF-1) levels and retinopathy of prematurity (ROP) remains unclear. This study aimed to investigate whether umbilical cord blood IGF-1 levels can predict the development of severe ROP in extremely preterm infants. Methods: This hospital-based retrospective cohort study included infants born at <37 weeks gestational age (GA) between 2019 and 2021 and then classified them into the two GA groups: extremely preterm, <28 weeks and preterm infants, 28–36 weeks. Extremely preterm infants were further subclassified into two groups according to the laser treatment as follows: the severe ROP (ROP-Tx) and ROP (No ROP-Tx) groups. Median umbilical cord blood IGF-1 values were compared between the groups. Perinatal risk factors were identified by univariate and multivariate analyses. Finally, umbilical cord IGF-1 cut-off values requiring ROP treatment with laser were determined by receiver operating characteristic (ROC) curve analyses. Results: A total of 205 infants were enrolled, with 32 being extremely preterm (ROP-Tx: n = 11; No ROP-Tx: n = 21) and 173 being preterm. IGF-1 levels were significantly lower in extremely preterm (13.5 ng/mL) than preterm infants (36 ng/mL, p < 0.001). In extremely preterm infants, IGF-1 levels were significantly lower in the ROP-Tx group than the No ROP-Tx group (10 vs. 19 ng/mL, respectively, p = 0.024). Only GA, umbilical cord blood IGF-1 levels, birth head circumference, and birth chest circumference were identified as risk factors by univariate analysis (p < 0.05). Multivariate analysis showed that only umbilical cord blood IGF-1 was an independent risk factor (odds ratio: 1.26, p = 0.021). ROC curves revealed an IGF-1 cut-off value of 14 ng/mL. Conclusion: The need of laser treatment for ROP was found to be associated with low umbilical cord blood IGF-1 levels in extremely preterm infants. Umbilical cord blood IGF-1 can be used as a biomarker for the risk of developing severe ROP. |
| first_indexed | 2024-04-09T21:01:11Z |
| format | Article |
| id | doaj.art-c125b68bb22d4067bb101b634dc5a04a |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-04-09T21:01:11Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-c125b68bb22d4067bb101b634dc5a04a2023-03-29T09:25:28ZengElsevierPediatrics and Neonatology1875-95722023-03-01642126132Association of umbilical cord insulin-like growth factor 1 levels with severe retinopathy in extremely preterm infantsNobuhiko Nagano0Daichi Katayama1Koichiro Hara2Takuya Akimoto3Takayuki Imaizumi4Ayako Seimiya5Ryoji Aoki6Midori Hijikata7Kazumasa Fuwa8Aya Okahashi9Ichiro Morioka10Corresponding author. Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1, Oyaguchi-kamimachi, Itabashi-ku, Tokyo 1738610, Japan.; Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, JapanBackground: The association between umbilical cord blood insulin-like growth factor 1 (IGF-1) levels and retinopathy of prematurity (ROP) remains unclear. This study aimed to investigate whether umbilical cord blood IGF-1 levels can predict the development of severe ROP in extremely preterm infants. Methods: This hospital-based retrospective cohort study included infants born at <37 weeks gestational age (GA) between 2019 and 2021 and then classified them into the two GA groups: extremely preterm, <28 weeks and preterm infants, 28–36 weeks. Extremely preterm infants were further subclassified into two groups according to the laser treatment as follows: the severe ROP (ROP-Tx) and ROP (No ROP-Tx) groups. Median umbilical cord blood IGF-1 values were compared between the groups. Perinatal risk factors were identified by univariate and multivariate analyses. Finally, umbilical cord IGF-1 cut-off values requiring ROP treatment with laser were determined by receiver operating characteristic (ROC) curve analyses. Results: A total of 205 infants were enrolled, with 32 being extremely preterm (ROP-Tx: n = 11; No ROP-Tx: n = 21) and 173 being preterm. IGF-1 levels were significantly lower in extremely preterm (13.5 ng/mL) than preterm infants (36 ng/mL, p < 0.001). In extremely preterm infants, IGF-1 levels were significantly lower in the ROP-Tx group than the No ROP-Tx group (10 vs. 19 ng/mL, respectively, p = 0.024). Only GA, umbilical cord blood IGF-1 levels, birth head circumference, and birth chest circumference were identified as risk factors by univariate analysis (p < 0.05). Multivariate analysis showed that only umbilical cord blood IGF-1 was an independent risk factor (odds ratio: 1.26, p = 0.021). ROC curves revealed an IGF-1 cut-off value of 14 ng/mL. Conclusion: The need of laser treatment for ROP was found to be associated with low umbilical cord blood IGF-1 levels in extremely preterm infants. Umbilical cord blood IGF-1 can be used as a biomarker for the risk of developing severe ROP.http://www.sciencedirect.com/science/article/pii/S1875957222002017gestational agelaser treatmentpreterm infantsreceiver operating characteristic curveretinopathy of prematurity |
| spellingShingle | Nobuhiko Nagano Daichi Katayama Koichiro Hara Takuya Akimoto Takayuki Imaizumi Ayako Seimiya Ryoji Aoki Midori Hijikata Kazumasa Fuwa Aya Okahashi Ichiro Morioka Association of umbilical cord insulin-like growth factor 1 levels with severe retinopathy in extremely preterm infants Pediatrics and Neonatology gestational age laser treatment preterm infants receiver operating characteristic curve retinopathy of prematurity |
| title | Association of umbilical cord insulin-like growth factor 1 levels with severe retinopathy in extremely preterm infants |
| title_full | Association of umbilical cord insulin-like growth factor 1 levels with severe retinopathy in extremely preterm infants |
| title_fullStr | Association of umbilical cord insulin-like growth factor 1 levels with severe retinopathy in extremely preterm infants |
| title_full_unstemmed | Association of umbilical cord insulin-like growth factor 1 levels with severe retinopathy in extremely preterm infants |
| title_short | Association of umbilical cord insulin-like growth factor 1 levels with severe retinopathy in extremely preterm infants |
| title_sort | association of umbilical cord insulin like growth factor 1 levels with severe retinopathy in extremely preterm infants |
| topic | gestational age laser treatment preterm infants receiver operating characteristic curve retinopathy of prematurity |
| url | http://www.sciencedirect.com/science/article/pii/S1875957222002017 |
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