A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis
Background Lung ultrasound (LUS) and computed tomography (CT) can both be used for diagnosis of interstitial pneumonia caused by coronavirus disease 2019 (COVID-19), but the agreement between LUS and CT is unknown. Purpose to compare the agreement of LUS and CT in the diagnosis of interstitial pneum...
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MDPI AG
2021-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/8/1351 |
| _version_ | 1797524193770733568 |
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| author | Mengshu Wang Xufei Luo Ling Wang Janne Estill Meng Lv Ying Zhu Qi Wang Xiaojuan Xiao Yang Song Myeong Soo Lee Hyeong Sik Ahn Junqiang Lei Jinhui Tian |
| author_facet | Mengshu Wang Xufei Luo Ling Wang Janne Estill Meng Lv Ying Zhu Qi Wang Xiaojuan Xiao Yang Song Myeong Soo Lee Hyeong Sik Ahn Junqiang Lei Jinhui Tian |
| author_sort | Mengshu Wang |
| collection | DOAJ |
| description | Background Lung ultrasound (LUS) and computed tomography (CT) can both be used for diagnosis of interstitial pneumonia caused by coronavirus disease 2019 (COVID-19), but the agreement between LUS and CT is unknown. Purpose to compare the agreement of LUS and CT in the diagnosis of interstitial pneumonia caused by COVID-19. Materials and Methods We searched PubMed, Cochrane library, Embase, Chinese Biomedicine Literature, and WHO COVID-19 databases to identify studies that compared LUS with CT in the diagnosis of interstitial pneumonia caused by COVID-19. We calculated the pooled overall, positive and negative percent agreements, diagnostic odds ratio (DOR) and the area under the standard receiver operating curve (SROC) for LUS in the diagnosis of COVID-19 compared with CT. Results We identified 1896 records, of which nine studies involving 531 patients were finally included. The pooled overall, positive and negative percentage agreements of LUS for the diagnosis of interstitial pneumonia caused by COVID-19 compared with CT were 81% (95% confidence interval [CI] 43–99%), 96% (95% CI, 80–99%, I<sup>2</sup> = 92.15%) and 80% (95%CI, 60–92%, I<sup>2</sup> = 92.85%), respectively. DOR was 37.41 (95% CI, 9.43–148.49, I<sup>2</sup> = 63.9%), and the area under the SROC curve was 0.94 (95% CI, 0.92–0.96). The quality of evidence for both specificity and sensitivity was low because of heterogeneity and risk of bias. Conclusion The level of diagnostic agreement between LUS and CT in the diagnosis of interstitial pneumonia caused by COVID-19 is high. LUS can be therefore considered as an equally accurate alternative for CT in situations where molecular tests are not available. |
| first_indexed | 2024-03-10T08:53:55Z |
| format | Article |
| id | doaj.art-c1279a2029bf4f28bcf2c168c695c601 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T08:53:55Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-c1279a2029bf4f28bcf2c168c695c6012023-11-22T07:19:16ZengMDPI AGDiagnostics2075-44182021-07-01118135110.3390/diagnostics11081351A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-AnalysisMengshu Wang0Xufei Luo1Ling Wang2Janne Estill3Meng Lv4Ying Zhu5Qi Wang6Xiaojuan Xiao7Yang Song8Myeong Soo Lee9Hyeong Sik Ahn10Junqiang Lei11Jinhui Tian12Evidence-Based Medicine Centre, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, ChinaSchool of Public Health, Lanzhou University, Lanzhou 730000, ChinaDepartment of Ultrasound, People’s Hospital of Gansu Province, Lanzhou 730000, ChinaInstitute of Global Health, University of Geneva, 1211 Geneva, SwitzerlandDepartment of Nephrology, Children’s Hospital of Chongqing Medical University, Chongqing 400014, ChinaEvidence-Based Medicine Centre, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, ChinaDepartment of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON L8S 4L8, CanadaDepartment of Radiology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, ChinaIberoamerican Cochrane Centre-Biomedical Research Institute Sant Pau (IIB Sant Pau), 08025 Barcelona, SpainKorea Institute of Oriental Medicine, Daejeon 34054, KoreaDepartment of Preventive Medicine, Korea University, Seoul 02841, KoreaDepartment of Radiology, The First Hospital of Lanzhou University, Lanzhou 730000, ChinaEvidence-Based Medicine Centre, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, ChinaBackground Lung ultrasound (LUS) and computed tomography (CT) can both be used for diagnosis of interstitial pneumonia caused by coronavirus disease 2019 (COVID-19), but the agreement between LUS and CT is unknown. Purpose to compare the agreement of LUS and CT in the diagnosis of interstitial pneumonia caused by COVID-19. Materials and Methods We searched PubMed, Cochrane library, Embase, Chinese Biomedicine Literature, and WHO COVID-19 databases to identify studies that compared LUS with CT in the diagnosis of interstitial pneumonia caused by COVID-19. We calculated the pooled overall, positive and negative percent agreements, diagnostic odds ratio (DOR) and the area under the standard receiver operating curve (SROC) for LUS in the diagnosis of COVID-19 compared with CT. Results We identified 1896 records, of which nine studies involving 531 patients were finally included. The pooled overall, positive and negative percentage agreements of LUS for the diagnosis of interstitial pneumonia caused by COVID-19 compared with CT were 81% (95% confidence interval [CI] 43–99%), 96% (95% CI, 80–99%, I<sup>2</sup> = 92.15%) and 80% (95%CI, 60–92%, I<sup>2</sup> = 92.85%), respectively. DOR was 37.41 (95% CI, 9.43–148.49, I<sup>2</sup> = 63.9%), and the area under the SROC curve was 0.94 (95% CI, 0.92–0.96). The quality of evidence for both specificity and sensitivity was low because of heterogeneity and risk of bias. Conclusion The level of diagnostic agreement between LUS and CT in the diagnosis of interstitial pneumonia caused by COVID-19 is high. LUS can be therefore considered as an equally accurate alternative for CT in situations where molecular tests are not available.https://www.mdpi.com/2075-4418/11/8/1351COVID-19systematic reviewPOCUSlung ultrasoundcomputed tomography |
| spellingShingle | Mengshu Wang Xufei Luo Ling Wang Janne Estill Meng Lv Ying Zhu Qi Wang Xiaojuan Xiao Yang Song Myeong Soo Lee Hyeong Sik Ahn Junqiang Lei Jinhui Tian A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis Diagnostics COVID-19 systematic review POCUS lung ultrasound computed tomography |
| title | A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis |
| title_full | A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis |
| title_fullStr | A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis |
| title_short | A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis |
| title_sort | comparison of lung ultrasound and computed tomography in the diagnosis of patients with covid 19 a systematic review and meta analysis |
| topic | COVID-19 systematic review POCUS lung ultrasound computed tomography |
| url | https://www.mdpi.com/2075-4418/11/8/1351 |
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