Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review
Chronic constipation affects around 20% of the population and there is no efficient solution. This perspective review explores the potential of colonic electric stimulation (CES) using neural implants and methods of bioelectronic medicine as a therapeutic way to treat chronic constipation. The revie...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/12/3/481 |
| _version_ | 1797242025588817920 |
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| author | Iñaki Ortego-Isasa Juan Francisco Ortega-Morán Héctor Lozano Thomas Stieglitz Francisco M. Sánchez-Margallo Jesús Usón-Gargallo J. Blas Pagador Ander Ramos-Murguialday |
| author_facet | Iñaki Ortego-Isasa Juan Francisco Ortega-Morán Héctor Lozano Thomas Stieglitz Francisco M. Sánchez-Margallo Jesús Usón-Gargallo J. Blas Pagador Ander Ramos-Murguialday |
| author_sort | Iñaki Ortego-Isasa |
| collection | DOAJ |
| description | Chronic constipation affects around 20% of the population and there is no efficient solution. This perspective review explores the potential of colonic electric stimulation (CES) using neural implants and methods of bioelectronic medicine as a therapeutic way to treat chronic constipation. The review covers the neurophysiology of colonic peristaltic function, the pathophysiology of chronic constipation, the technical aspects of CES, including stimulation parameters, electrode placement, and neuromodulation target selection, as well as a comprehensive analysis of various animal models highlighting their advantages and limitations in elucidating the mechanistic insights and translational relevance for CES. Finally, the main challenges and trends in CES are discussed. |
| first_indexed | 2024-04-24T18:32:40Z |
| format | Article |
| id | doaj.art-c1283b13014446ca91d7211fa53ca5d4 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-04-24T18:32:40Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-c1283b13014446ca91d7211fa53ca5d42024-03-27T13:22:28ZengMDPI AGBiomedicines2227-90592024-02-0112348110.3390/biomedicines12030481Colonic Electrical Stimulation for Chronic Constipation: A Perspective ReviewIñaki Ortego-Isasa0Juan Francisco Ortega-Morán1Héctor Lozano2Thomas Stieglitz3Francisco M. Sánchez-Margallo4Jesús Usón-Gargallo5J. Blas Pagador6Ander Ramos-Murguialday7TECNALIA, Basque Research and Technology Alliance (BRTA), 20009 San Sebastian, SpainJesús Usón Minimally Invasive Surgery Centre, 10071 Cáceres, SpainTECNALIA, Basque Research and Technology Alliance (BRTA), 20009 San Sebastian, SpainLaboratory for Biomedical Microtechnology, Department of Microsystems Engineering–IMTEK and BrainLinks-BrainTools Center, University of Freiburg, 79110 Freiburg, GermanyJesús Usón Minimally Invasive Surgery Centre, 10071 Cáceres, SpainJesús Usón Minimally Invasive Surgery Centre, 10071 Cáceres, SpainJesús Usón Minimally Invasive Surgery Centre, 10071 Cáceres, SpainTECNALIA, Basque Research and Technology Alliance (BRTA), 20009 San Sebastian, SpainChronic constipation affects around 20% of the population and there is no efficient solution. This perspective review explores the potential of colonic electric stimulation (CES) using neural implants and methods of bioelectronic medicine as a therapeutic way to treat chronic constipation. The review covers the neurophysiology of colonic peristaltic function, the pathophysiology of chronic constipation, the technical aspects of CES, including stimulation parameters, electrode placement, and neuromodulation target selection, as well as a comprehensive analysis of various animal models highlighting their advantages and limitations in elucidating the mechanistic insights and translational relevance for CES. Finally, the main challenges and trends in CES are discussed.https://www.mdpi.com/2227-9059/12/3/481constipationcolonic electric stimulation (CES)bioelectronicsneural implant |
| spellingShingle | Iñaki Ortego-Isasa Juan Francisco Ortega-Morán Héctor Lozano Thomas Stieglitz Francisco M. Sánchez-Margallo Jesús Usón-Gargallo J. Blas Pagador Ander Ramos-Murguialday Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review Biomedicines constipation colonic electric stimulation (CES) bioelectronics neural implant |
| title | Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review |
| title_full | Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review |
| title_fullStr | Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review |
| title_full_unstemmed | Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review |
| title_short | Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review |
| title_sort | colonic electrical stimulation for chronic constipation a perspective review |
| topic | constipation colonic electric stimulation (CES) bioelectronics neural implant |
| url | https://www.mdpi.com/2227-9059/12/3/481 |
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