Long‐term case study of a Wuzhishan miniature pig with diabetes
Abstract Background Miniature pigs are attractive animal models for exploring diabetes because they are similar to humans in terms of physiological structure and metabolism. However, little is known about the complications of diabetes in pigs. Methods In this study, a 28‐month observation of a Wuzhi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-03-01
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| Series: | Animal Models and Experimental Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ame2.12098 |
| _version_ | 1819320071415136256 |
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| author | Miaomiao Niu Yaqian Liu Lei Xiang Yuqiong Zhao Jifang Yuan Yunxiao Jia Xin Dai Hua Chen |
| author_facet | Miaomiao Niu Yaqian Liu Lei Xiang Yuqiong Zhao Jifang Yuan Yunxiao Jia Xin Dai Hua Chen |
| author_sort | Miaomiao Niu |
| collection | DOAJ |
| description | Abstract Background Miniature pigs are attractive animal models for exploring diabetes because they are similar to humans in terms of physiological structure and metabolism. However, little is known about the complications of diabetes in pigs. Methods In this study, a 28‐month observation of a Wuzhishan miniature pig with streptozotocin (STZ)‐induced (120 mg/kg) diabetes was conducted, to investigate diabetes‐related complications and the possibility of self‐recovery in miniature pigs. Blood glucose, serum and urinary biochemistry was measured, and histopathologic examinations of eyes, kidney and pancreas were made. Results During the observation, diabetic complications of eyes and kidney were observed. The eye complications included bilateral cataracts in the 15th month and degeneration of inner retina and microaneurysm in the 28th month. Kidney complications included glomerular mesangial expansion, focal segmental glomerular sclerosis, and renal tubular epithelial degeneration, but no proteinuria was observed. By 28 months after the application of STZ, with no treatment given, blood glucose had recovered and the number of pancreatic islet beta‐cells had increased significantly. Conclusions We showed that the STZ‐induced diabetes model in miniature pigs could accurately mimic the pathological changes of human diabetes, and that pancreatic islet beta‐cell regeneration did occur in an adult miniature pig, providing a new means for exploring diabetic complications and pancreatic islet beta‐cell regeneration. |
| first_indexed | 2024-12-24T11:13:45Z |
| format | Article |
| id | doaj.art-c12899888e6a4ebebc6ab597e2a9ac3a |
| institution | Directory Open Access Journal |
| issn | 2576-2095 |
| language | English |
| last_indexed | 2024-12-24T11:13:45Z |
| publishDate | 2020-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Models and Experimental Medicine |
| spelling | doaj.art-c12899888e6a4ebebc6ab597e2a9ac3a2022-12-21T16:58:27ZengWileyAnimal Models and Experimental Medicine2576-20952020-03-0131223110.1002/ame2.12098Long‐term case study of a Wuzhishan miniature pig with diabetesMiaomiao Niu0Yaqian Liu1Lei Xiang2Yuqiong Zhao3Jifang Yuan4Yunxiao Jia5Xin Dai6Hua Chen7Laboratory Animal Center Chinese PLA General Hospital Beijing PR ChinaLaboratory Animal Center Chinese PLA General Hospital Beijing PR ChinaLaboratory Animal Center Chinese PLA General Hospital Beijing PR ChinaLaboratory Animal Center Chinese PLA General Hospital Beijing PR ChinaLaboratory Animal Center Chinese PLA General Hospital Beijing PR ChinaLaboratory Animal Center Chinese PLA General Hospital Beijing PR ChinaLaboratory Animal Center Chinese PLA General Hospital Beijing PR ChinaLaboratory Animal Center Chinese PLA General Hospital Beijing PR ChinaAbstract Background Miniature pigs are attractive animal models for exploring diabetes because they are similar to humans in terms of physiological structure and metabolism. However, little is known about the complications of diabetes in pigs. Methods In this study, a 28‐month observation of a Wuzhishan miniature pig with streptozotocin (STZ)‐induced (120 mg/kg) diabetes was conducted, to investigate diabetes‐related complications and the possibility of self‐recovery in miniature pigs. Blood glucose, serum and urinary biochemistry was measured, and histopathologic examinations of eyes, kidney and pancreas were made. Results During the observation, diabetic complications of eyes and kidney were observed. The eye complications included bilateral cataracts in the 15th month and degeneration of inner retina and microaneurysm in the 28th month. Kidney complications included glomerular mesangial expansion, focal segmental glomerular sclerosis, and renal tubular epithelial degeneration, but no proteinuria was observed. By 28 months after the application of STZ, with no treatment given, blood glucose had recovered and the number of pancreatic islet beta‐cells had increased significantly. Conclusions We showed that the STZ‐induced diabetes model in miniature pigs could accurately mimic the pathological changes of human diabetes, and that pancreatic islet beta‐cell regeneration did occur in an adult miniature pig, providing a new means for exploring diabetic complications and pancreatic islet beta‐cell regeneration.https://doi.org/10.1002/ame2.12098beta‐cell regenerationdiabetes‐related complicationspig |
| spellingShingle | Miaomiao Niu Yaqian Liu Lei Xiang Yuqiong Zhao Jifang Yuan Yunxiao Jia Xin Dai Hua Chen Long‐term case study of a Wuzhishan miniature pig with diabetes Animal Models and Experimental Medicine beta‐cell regeneration diabetes‐related complications pig |
| title | Long‐term case study of a Wuzhishan miniature pig with diabetes |
| title_full | Long‐term case study of a Wuzhishan miniature pig with diabetes |
| title_fullStr | Long‐term case study of a Wuzhishan miniature pig with diabetes |
| title_full_unstemmed | Long‐term case study of a Wuzhishan miniature pig with diabetes |
| title_short | Long‐term case study of a Wuzhishan miniature pig with diabetes |
| title_sort | long term case study of a wuzhishan miniature pig with diabetes |
| topic | beta‐cell regeneration diabetes‐related complications pig |
| url | https://doi.org/10.1002/ame2.12098 |
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