Protective effect of Rheum turkestanicum against cisplatin by reducing oxidative stress in kidney tissue
Background: Cisplatin is used as chemotherapeutic drug in the treatment of some solid tumors. It causes different side effects such as nephrotoxicity because of increasing oxidative stress and reactive oxygen species production. This study was designed to investigate the effect of Rheum turkestanicu...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2018;volume=10;issue=2;spage=66;epage=71;aulast=Hosseini |
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| author | Azar Hosseini Sahar Fanoudi Hamid Mollazadeh Azita Aghaei Mohammad Taher Boroushaki |
| author_facet | Azar Hosseini Sahar Fanoudi Hamid Mollazadeh Azita Aghaei Mohammad Taher Boroushaki |
| author_sort | Azar Hosseini |
| collection | DOAJ |
| description | Background: Cisplatin is used as chemotherapeutic drug in the treatment of some solid tumors. It causes different side effects such as nephrotoxicity because of increasing oxidative stress and reactive oxygen species production. This study was designed to investigate the effect of Rheum turkestanicum on cisplatin-induced nephrotoxicity in rat. Materials and Methods: Animals were randomly divided into four groups (six each). Group I received normal saline (1mL/day, intraperitoneally [i.p.]). Group II received a single dose of cisplatin (8mg/kg, i.p.). Groups III and IV received extract at doses of 100mg/kg and 200mg/kg, i.p., respectively, for 3 consecutive days, 1h before a single dose of cisplatin only at the first day. Blood samples were taken for measuring the level of urea and creatinine. Furthermore, 24-h urinary factors such as glucose and protein were measured. Histopathological observation was carried out on kidney sections. Statistical analysis was performed using one-way analysis of variance followed by Tukey–Kramer post hoc test for multiple comparisons. Results: Cisplatin increased the lipid peroxidation, serum creatinine, serum urea, urinary glucose, and urinary protein, whereas decreased the content of thiol in kidney. The extract reduced serum creatinine, serum urea, urinary glucose, urinary protein, lipid peroxidation, and increased thiol following cisplatin administration. Histological studies revealed lower lesions in kidney in the extract-treated groups compared to cisplatin-treated one. Conclusion: This research showed the extract has protective effect against cisplatin-induced nephrotoxicity. This observation may be related to antioxidant properties of the extract. |
| first_indexed | 2024-04-14T00:59:39Z |
| format | Article |
| id | doaj.art-c12ab280d17e450c9ebe6aae528d3c15 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 |
| language | English |
| last_indexed | 2024-04-14T00:59:39Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-c12ab280d17e450c9ebe6aae528d3c152022-12-22T02:21:27ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062018-01-01102667110.4103/JPBS.JPBS_9_18Protective effect of Rheum turkestanicum against cisplatin by reducing oxidative stress in kidney tissueAzar HosseiniSahar FanoudiHamid MollazadehAzita AghaeiMohammad Taher BoroushakiBackground: Cisplatin is used as chemotherapeutic drug in the treatment of some solid tumors. It causes different side effects such as nephrotoxicity because of increasing oxidative stress and reactive oxygen species production. This study was designed to investigate the effect of Rheum turkestanicum on cisplatin-induced nephrotoxicity in rat. Materials and Methods: Animals were randomly divided into four groups (six each). Group I received normal saline (1mL/day, intraperitoneally [i.p.]). Group II received a single dose of cisplatin (8mg/kg, i.p.). Groups III and IV received extract at doses of 100mg/kg and 200mg/kg, i.p., respectively, for 3 consecutive days, 1h before a single dose of cisplatin only at the first day. Blood samples were taken for measuring the level of urea and creatinine. Furthermore, 24-h urinary factors such as glucose and protein were measured. Histopathological observation was carried out on kidney sections. Statistical analysis was performed using one-way analysis of variance followed by Tukey–Kramer post hoc test for multiple comparisons. Results: Cisplatin increased the lipid peroxidation, serum creatinine, serum urea, urinary glucose, and urinary protein, whereas decreased the content of thiol in kidney. The extract reduced serum creatinine, serum urea, urinary glucose, urinary protein, lipid peroxidation, and increased thiol following cisplatin administration. Histological studies revealed lower lesions in kidney in the extract-treated groups compared to cisplatin-treated one. Conclusion: This research showed the extract has protective effect against cisplatin-induced nephrotoxicity. This observation may be related to antioxidant properties of the extract.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2018;volume=10;issue=2;spage=66;epage=71;aulast=HosseiniCisplatinnephrotoxicityRheum turkestanicumROSoxidative stress |
| spellingShingle | Azar Hosseini Sahar Fanoudi Hamid Mollazadeh Azita Aghaei Mohammad Taher Boroushaki Protective effect of Rheum turkestanicum against cisplatin by reducing oxidative stress in kidney tissue Journal of Pharmacy and Bioallied Sciences Cisplatin nephrotoxicity Rheum turkestanicum ROS oxidative stress |
| title | Protective effect of Rheum turkestanicum against cisplatin by reducing oxidative stress in kidney tissue |
| title_full | Protective effect of Rheum turkestanicum against cisplatin by reducing oxidative stress in kidney tissue |
| title_fullStr | Protective effect of Rheum turkestanicum against cisplatin by reducing oxidative stress in kidney tissue |
| title_full_unstemmed | Protective effect of Rheum turkestanicum against cisplatin by reducing oxidative stress in kidney tissue |
| title_short | Protective effect of Rheum turkestanicum against cisplatin by reducing oxidative stress in kidney tissue |
| title_sort | protective effect of rheum turkestanicum against cisplatin by reducing oxidative stress in kidney tissue |
| topic | Cisplatin nephrotoxicity Rheum turkestanicum ROS oxidative stress |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2018;volume=10;issue=2;spage=66;epage=71;aulast=Hosseini |
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