Monoclonal Gammopathy of Undetermined Cardiovascular Significance; Current Evidence and Novel Insights
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition characterized by the presence of low levels of a monoclonal protein in the serum and a low percentage of clonal plasma cells in the bone marrow. MGUS may progress to multiple myeloma or other plasma cell disorders...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/10/12/484 |
| _version_ | 1827574579299614720 |
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| author | Anastasios Tentolouris Ioannis Ntanasis-Stathopoulos Maria Gavriatopoulou Ioanna Andreadou Evangelos Terpos |
| author_facet | Anastasios Tentolouris Ioannis Ntanasis-Stathopoulos Maria Gavriatopoulou Ioanna Andreadou Evangelos Terpos |
| author_sort | Anastasios Tentolouris |
| collection | DOAJ |
| description | Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition characterized by the presence of low levels of a monoclonal protein in the serum and a low percentage of clonal plasma cells in the bone marrow. MGUS may progress to multiple myeloma or other plasma cell disorders at a rate of 1% annually. However, MGUS may also have adverse effects on the cardiovascular system independent of its malignant potential. Emerging data have shown that MGUS is associated with cardiovascular disease. The mechanisms underlying this association are not fully understood but may involve genetic abnormalities, vascular calcification, cryoglobulinemia, cold agglutinin disease, autoantibodies and the direct or indirect effects of the monoclonal protein on the vascular endothelium. Herein, we review current evidence in this field and we suggest that patients with MGUS may benefit from regular cardiovascular risk assessment to prevent severe cardiovascular complications, in parallel with close hematological follow-up to monitor potential disease progression. |
| first_indexed | 2024-03-08T20:40:10Z |
| format | Article |
| id | doaj.art-c12c053296784cf899be3ab46cc69394 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-08T20:40:10Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-c12c053296784cf899be3ab46cc693942023-12-22T14:16:43ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-12-01101248410.3390/jcdd10120484Monoclonal Gammopathy of Undetermined Cardiovascular Significance; Current Evidence and Novel InsightsAnastasios Tentolouris0Ioannis Ntanasis-Stathopoulos1Maria Gavriatopoulou2Ioanna Andreadou3Evangelos Terpos4First Department of Propaedeutic Internal Medicine and Diabetes Center, School of Medicine, National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, GreeceDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Alexandra General Hospital, 11528 Athens, GreeceDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Alexandra General Hospital, 11528 Athens, GreeceLaboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, GreeceDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Alexandra General Hospital, 11528 Athens, GreeceMonoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition characterized by the presence of low levels of a monoclonal protein in the serum and a low percentage of clonal plasma cells in the bone marrow. MGUS may progress to multiple myeloma or other plasma cell disorders at a rate of 1% annually. However, MGUS may also have adverse effects on the cardiovascular system independent of its malignant potential. Emerging data have shown that MGUS is associated with cardiovascular disease. The mechanisms underlying this association are not fully understood but may involve genetic abnormalities, vascular calcification, cryoglobulinemia, cold agglutinin disease, autoantibodies and the direct or indirect effects of the monoclonal protein on the vascular endothelium. Herein, we review current evidence in this field and we suggest that patients with MGUS may benefit from regular cardiovascular risk assessment to prevent severe cardiovascular complications, in parallel with close hematological follow-up to monitor potential disease progression.https://www.mdpi.com/2308-3425/10/12/484MGUScardiovascular diseasemyocardial infarctionstrokeperipheral arterial disease |
| spellingShingle | Anastasios Tentolouris Ioannis Ntanasis-Stathopoulos Maria Gavriatopoulou Ioanna Andreadou Evangelos Terpos Monoclonal Gammopathy of Undetermined Cardiovascular Significance; Current Evidence and Novel Insights Journal of Cardiovascular Development and Disease MGUS cardiovascular disease myocardial infarction stroke peripheral arterial disease |
| title | Monoclonal Gammopathy of Undetermined Cardiovascular Significance; Current Evidence and Novel Insights |
| title_full | Monoclonal Gammopathy of Undetermined Cardiovascular Significance; Current Evidence and Novel Insights |
| title_fullStr | Monoclonal Gammopathy of Undetermined Cardiovascular Significance; Current Evidence and Novel Insights |
| title_full_unstemmed | Monoclonal Gammopathy of Undetermined Cardiovascular Significance; Current Evidence and Novel Insights |
| title_short | Monoclonal Gammopathy of Undetermined Cardiovascular Significance; Current Evidence and Novel Insights |
| title_sort | monoclonal gammopathy of undetermined cardiovascular significance current evidence and novel insights |
| topic | MGUS cardiovascular disease myocardial infarction stroke peripheral arterial disease |
| url | https://www.mdpi.com/2308-3425/10/12/484 |
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