The association between cystatin C and COPD: a meta-analysis and systematic review
Abstract Background In recent years, many studies have discovered that cystatin C (Cys C) may play an important role in respiratory diseases, especially in chronic obstructive pulmonary disease (COPD). However, the findings of these studies were inconsistent. This systematic review and meta-analysis...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12890-020-01208-5 |
| _version_ | 1818278250150887424 |
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| author | Limin Chai Wei Feng Cui Zhai Wenhua Shi Jian Wang Xin Yan Qingting Wang Qianqian Zhang Manxiang Li |
| author_facet | Limin Chai Wei Feng Cui Zhai Wenhua Shi Jian Wang Xin Yan Qingting Wang Qianqian Zhang Manxiang Li |
| author_sort | Limin Chai |
| collection | DOAJ |
| description | Abstract Background In recent years, many studies have discovered that cystatin C (Cys C) may play an important role in respiratory diseases, especially in chronic obstructive pulmonary disease (COPD). However, the findings of these studies were inconsistent. This systematic review and meta-analysis aimed to assess the relationship between serum Cys C and COPD. Methods We conducted a systematic literature search in PubMed, Embase, Web of Science, Wanfang databases, and the China National Knowledge Infrastructure. The standardized mean difference (SMD), Fisher’s Z-value and 95% confidence interval (CI) were calculated to investigate the effect sizes. Subgroup analyses were performed on disease status, ethnicity, assay method, and study design. Sensitivity was performed, and publication bias was assessed. Results A total of 15 studies, including 4079 COPD patients and 5949 controls, were included in this meta-analysis. The results showed that serum Cys C levels in patients with COPD were significantly higher than those in controls (SMD = 0.99, 95% CI =0.62–1.37, P < 0.001), especially in AECOPD (SMD = 1.59, 95% CI =1.05–2.13, P < 0.001), and there were statistically different among AECOPD and SCOPD (SMD = 0.35, 95% CI =0.10–0.59, P = 0.005). The serum Cys C levels were negatively correlated with FEV1%pre (Z = − 0.45, 95%CI = -0.58--0.32, P = 0.011) and FEV1/FVC (Z = − 0.32, 95%CI = -0.50--0.14, P = 0.006). The serum Cys C levels were independent of ethnicity, assay method, and study design. Conclusion Serum Cys C levels were associated with COPD and COPD exacerbation, and they were inversely correlated with FEV1%pre and FEV1/FVC. |
| first_indexed | 2024-12-12T23:14:27Z |
| format | Article |
| id | doaj.art-c12c91be6ccf45cd95c8d93446637cbb |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-12T23:14:27Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-c12c91be6ccf45cd95c8d93446637cbb2022-12-22T00:08:31ZengBMCBMC Pulmonary Medicine1471-24662020-06-0120111110.1186/s12890-020-01208-5The association between cystatin C and COPD: a meta-analysis and systematic reviewLimin Chai0Wei Feng1Cui Zhai2Wenhua Shi3Jian Wang4Xin Yan5Qingting Wang6Qianqian Zhang7Manxiang Li8Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi’an Jiaotong UniversityAbstract Background In recent years, many studies have discovered that cystatin C (Cys C) may play an important role in respiratory diseases, especially in chronic obstructive pulmonary disease (COPD). However, the findings of these studies were inconsistent. This systematic review and meta-analysis aimed to assess the relationship between serum Cys C and COPD. Methods We conducted a systematic literature search in PubMed, Embase, Web of Science, Wanfang databases, and the China National Knowledge Infrastructure. The standardized mean difference (SMD), Fisher’s Z-value and 95% confidence interval (CI) were calculated to investigate the effect sizes. Subgroup analyses were performed on disease status, ethnicity, assay method, and study design. Sensitivity was performed, and publication bias was assessed. Results A total of 15 studies, including 4079 COPD patients and 5949 controls, were included in this meta-analysis. The results showed that serum Cys C levels in patients with COPD were significantly higher than those in controls (SMD = 0.99, 95% CI =0.62–1.37, P < 0.001), especially in AECOPD (SMD = 1.59, 95% CI =1.05–2.13, P < 0.001), and there were statistically different among AECOPD and SCOPD (SMD = 0.35, 95% CI =0.10–0.59, P = 0.005). The serum Cys C levels were negatively correlated with FEV1%pre (Z = − 0.45, 95%CI = -0.58--0.32, P = 0.011) and FEV1/FVC (Z = − 0.32, 95%CI = -0.50--0.14, P = 0.006). The serum Cys C levels were independent of ethnicity, assay method, and study design. Conclusion Serum Cys C levels were associated with COPD and COPD exacerbation, and they were inversely correlated with FEV1%pre and FEV1/FVC.http://link.springer.com/article/10.1186/s12890-020-01208-5Cys CCOPDExacerbationMeta-analysis |
| spellingShingle | Limin Chai Wei Feng Cui Zhai Wenhua Shi Jian Wang Xin Yan Qingting Wang Qianqian Zhang Manxiang Li The association between cystatin C and COPD: a meta-analysis and systematic review BMC Pulmonary Medicine Cys C COPD Exacerbation Meta-analysis |
| title | The association between cystatin C and COPD: a meta-analysis and systematic review |
| title_full | The association between cystatin C and COPD: a meta-analysis and systematic review |
| title_fullStr | The association between cystatin C and COPD: a meta-analysis and systematic review |
| title_full_unstemmed | The association between cystatin C and COPD: a meta-analysis and systematic review |
| title_short | The association between cystatin C and COPD: a meta-analysis and systematic review |
| title_sort | association between cystatin c and copd a meta analysis and systematic review |
| topic | Cys C COPD Exacerbation Meta-analysis |
| url | http://link.springer.com/article/10.1186/s12890-020-01208-5 |
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