Association between infection with Chlamydia pneumonia and cerebral noncardioembolic ischemic stroke
Introduction: Stroke is the third most common cause of mortality and the most common disability disorder among adults. We aimed to study the relationship between Chlamydia pneumonia infection and non-cardio Ambulatory ischemic stroke.Methods: This case-control study was performed on 162 patients wit...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Iran University of Medical Sciences
2022-06-01
|
| Series: | Neurology Letters |
| Subjects: | |
| Online Access: | https://www.neurologyletters.com/article_158065_a1b689d193949ce8854fae325763e14c.pdf |
| _version_ | 1797630555146158080 |
|---|---|
| author | Seyed Amir Abbas Ahadiat Seyed-Ali Masoud Mohammad sadegh Khorshidi Zeinab Hosseinian Mahbobeh Haghshenas Jazi Ebrahim Kouchaki Javad Abolhasani |
| author_facet | Seyed Amir Abbas Ahadiat Seyed-Ali Masoud Mohammad sadegh Khorshidi Zeinab Hosseinian Mahbobeh Haghshenas Jazi Ebrahim Kouchaki Javad Abolhasani |
| author_sort | Seyed Amir Abbas Ahadiat |
| collection | DOAJ |
| description | Introduction: Stroke is the third most common cause of mortality and the most common disability disorder among adults. We aimed to study the relationship between Chlamydia pneumonia infection and non-cardio Ambulatory ischemic stroke.Methods: This case-control study was performed on 162 patients with non-cardio ambulatory ischemic stroke admitted to Shahid Beheshti Hospital of Kashan in 2019 as the case group and patients with neurological headache and degenerative diseases as the control group. After filling out the questionnaire for all subjects, we took blood samples. We analyzed all three anti-chlamydia pneumonia antibodies (IgM, IgG, IgA) by ELISA method after data were analyzed by Chi-square and Fisher tests.Results: The findings of this study showed that positive IgA in the stroke group was significantly higher than in the control group (p=0.001); it was also found that the risk factors of HTN (p=0.001), HLP (p=0.001), DM (p=0.001), and age (p = 0.049) were significantly higher in the stroke patients’ group than the control group. On the other hand, there was not a significant difference in serum IgG level (p = 0.349), IgM (p = 0.745), smoking (p = 0.211) and gender (p = 0.157) in understudied groups.Conclusion: Chlamydia IgA antibodies can be a complementary tool for predicting prognosis and monitoring new therapies for ischemic stroke. This study provides a way for further studies, especially with other markers of acute and chronic systemic Chlamydia pneumonia infection. Antibiotic treatment significantly helps to reduce mortality and stroke complications. |
| first_indexed | 2024-03-11T11:09:49Z |
| format | Article |
| id | doaj.art-c12debbff1e643c3bf903dcbd94a37f6 |
| institution | Directory Open Access Journal |
| issn | 2821-1723 |
| language | English |
| last_indexed | 2024-03-11T11:09:49Z |
| publishDate | 2022-06-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Neurology Letters |
| spelling | doaj.art-c12debbff1e643c3bf903dcbd94a37f62023-11-12T09:10:00ZengIran University of Medical SciencesNeurology Letters2821-17232022-06-0111394310.52547/nl.1.1.39158065Association between infection with Chlamydia pneumonia and cerebral noncardioembolic ischemic strokeSeyed Amir Abbas Ahadiat0Seyed-Ali Masoud1Mohammad sadegh Khorshidi2Zeinab Hosseinian3Mahbobeh Haghshenas Jazi4Ebrahim Kouchaki5Javad Abolhasani6Orde van Artsen, Brussel, BelgiumDepartment of Neurology, School of Medicine, Trauma Nursing Research Center, Kashan University of Medical Sciences, Kashan, IranDepartment of Neurology, Kashan University of medical science, Kashan, IranUniversitat de Girona, Department Molecular Biology, Biomedicine, Girona, SpainDepartment of Neurology, Kashan University of medical science, Kashan, IranDepartment of Neurology, School of Medicine, Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, IranDepartment of Neurology, Kashan University of medical science, Kashan, IranIntroduction: Stroke is the third most common cause of mortality and the most common disability disorder among adults. We aimed to study the relationship between Chlamydia pneumonia infection and non-cardio Ambulatory ischemic stroke.Methods: This case-control study was performed on 162 patients with non-cardio ambulatory ischemic stroke admitted to Shahid Beheshti Hospital of Kashan in 2019 as the case group and patients with neurological headache and degenerative diseases as the control group. After filling out the questionnaire for all subjects, we took blood samples. We analyzed all three anti-chlamydia pneumonia antibodies (IgM, IgG, IgA) by ELISA method after data were analyzed by Chi-square and Fisher tests.Results: The findings of this study showed that positive IgA in the stroke group was significantly higher than in the control group (p=0.001); it was also found that the risk factors of HTN (p=0.001), HLP (p=0.001), DM (p=0.001), and age (p = 0.049) were significantly higher in the stroke patients’ group than the control group. On the other hand, there was not a significant difference in serum IgG level (p = 0.349), IgM (p = 0.745), smoking (p = 0.211) and gender (p = 0.157) in understudied groups.Conclusion: Chlamydia IgA antibodies can be a complementary tool for predicting prognosis and monitoring new therapies for ischemic stroke. This study provides a way for further studies, especially with other markers of acute and chronic systemic Chlamydia pneumonia infection. Antibiotic treatment significantly helps to reduce mortality and stroke complications.https://www.neurologyletters.com/article_158065_a1b689d193949ce8854fae325763e14c.pdfnon-cardioembolicstrokeatherosclerosisantibodyinfectionchlamydia |
| spellingShingle | Seyed Amir Abbas Ahadiat Seyed-Ali Masoud Mohammad sadegh Khorshidi Zeinab Hosseinian Mahbobeh Haghshenas Jazi Ebrahim Kouchaki Javad Abolhasani Association between infection with Chlamydia pneumonia and cerebral noncardioembolic ischemic stroke Neurology Letters non-cardioembolic stroke atherosclerosis antibody infection chlamydia |
| title | Association between infection with Chlamydia pneumonia and cerebral noncardioembolic ischemic stroke |
| title_full | Association between infection with Chlamydia pneumonia and cerebral noncardioembolic ischemic stroke |
| title_fullStr | Association between infection with Chlamydia pneumonia and cerebral noncardioembolic ischemic stroke |
| title_full_unstemmed | Association between infection with Chlamydia pneumonia and cerebral noncardioembolic ischemic stroke |
| title_short | Association between infection with Chlamydia pneumonia and cerebral noncardioembolic ischemic stroke |
| title_sort | association between infection with chlamydia pneumonia and cerebral noncardioembolic ischemic stroke |
| topic | non-cardioembolic stroke atherosclerosis antibody infection chlamydia |
| url | https://www.neurologyletters.com/article_158065_a1b689d193949ce8854fae325763e14c.pdf |
| work_keys_str_mv | AT seyedamirabbasahadiat associationbetweeninfectionwithchlamydiapneumoniaandcerebralnoncardioembolicischemicstroke AT seyedalimasoud associationbetweeninfectionwithchlamydiapneumoniaandcerebralnoncardioembolicischemicstroke AT mohammadsadeghkhorshidi associationbetweeninfectionwithchlamydiapneumoniaandcerebralnoncardioembolicischemicstroke AT zeinabhosseinian associationbetweeninfectionwithchlamydiapneumoniaandcerebralnoncardioembolicischemicstroke AT mahbobehhaghshenasjazi associationbetweeninfectionwithchlamydiapneumoniaandcerebralnoncardioembolicischemicstroke AT ebrahimkouchaki associationbetweeninfectionwithchlamydiapneumoniaandcerebralnoncardioembolicischemicstroke AT javadabolhasani associationbetweeninfectionwithchlamydiapneumoniaandcerebralnoncardioembolicischemicstroke |