Integrated in silico MS-based phosphoproteomics and network enrichment analysis of RASopathy proteins

Integrated in silico MS-based phosphoproteomics and network enrichment analysis of RASopathy proteins

Abstract Background RASopathies are a group of syndromes showing clinical overlap caused by mutations in genes affecting the RAS-MAPK pathway. Consequent disruption on cellular signaling leads and is driven by phosphoproteome remodeling. However, we still lack a comprehensive picture of the differen...

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Bibliographic Details
Main Authors: Javier-Fernando Montero-Bullón, Óscar González-Velasco, María Isidoro-García, Jesus Lacal
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Phosphoproteomics
Interactomics
RASopathies
Neurofibromatosis
Noonan syndrome
Mass spectrometry
Online Access:https://doi.org/10.1186/s13023-021-01934-x

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