MicroRNAs in health and disease
MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs about 21-25 nucleotides in length and account for 1%-5% of the genome. Ever since its discovery in 1993, these molecules have attracted researchers due to their crucial role in regulating gene expression. Dysregulation in miRNA expre...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Journal of Clinical and Scientific Research |
| Subjects: | |
| Online Access: | http://www.jcsr.co.in/article.asp?issn=2277-5706;year=2017;volume=6;issue=1;spage=25;epage=34;aulast=Rama;type=0 |
| _version_ | 1798022135495524352 |
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| author | K Rama P.V.L.N Srinivasa Rao Aparna R Bitla |
| author_facet | K Rama P.V.L.N Srinivasa Rao Aparna R Bitla |
| author_sort | K Rama |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs about 21-25 nucleotides in length and account for 1%-5% of the genome. Ever since its discovery in 1993, these molecules have attracted researchers due to their crucial role in regulating gene expression. Dysregulation in miRNA expression profile could serve as molecular signatures for identifying diseases. These have found applications in a number of diseases including cancer, wherein they may be useful for as biomarkers in cancer diagnosis as well as serve as therapeutic targets. This review provides an update on the evolution of miRNAs in the field of medicine and its future therapeutic applications. |
| first_indexed | 2024-04-11T17:24:53Z |
| format | Article |
| id | doaj.art-c12fae8fbd9e4ec1a053a961b321185b |
| institution | Directory Open Access Journal |
| issn | 2277-5706 2277-8357 |
| language | English |
| last_indexed | 2024-04-11T17:24:53Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical and Scientific Research |
| spelling | doaj.art-c12fae8fbd9e4ec1a053a961b321185b2022-12-22T04:12:23ZengWolters Kluwer Medknow PublicationsJournal of Clinical and Scientific Research2277-57062277-83572017-01-0161253410.15380/2277-5706.JCSR.16.11.006MicroRNAs in health and diseaseK RamaP.V.L.N Srinivasa RaoAparna R BitlaMicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs about 21-25 nucleotides in length and account for 1%-5% of the genome. Ever since its discovery in 1993, these molecules have attracted researchers due to their crucial role in regulating gene expression. Dysregulation in miRNA expression profile could serve as molecular signatures for identifying diseases. These have found applications in a number of diseases including cancer, wherein they may be useful for as biomarkers in cancer diagnosis as well as serve as therapeutic targets. This review provides an update on the evolution of miRNAs in the field of medicine and its future therapeutic applications.http://www.jcsr.co.in/article.asp?issn=2277-5706;year=2017;volume=6;issue=1;spage=25;epage=34;aulast=Rama;type=0micrornasbiomarkerstranscriptome |
| spellingShingle | K Rama P.V.L.N Srinivasa Rao Aparna R Bitla MicroRNAs in health and disease Journal of Clinical and Scientific Research micrornas biomarkers transcriptome |
| title | MicroRNAs in health and disease |
| title_full | MicroRNAs in health and disease |
| title_fullStr | MicroRNAs in health and disease |
| title_full_unstemmed | MicroRNAs in health and disease |
| title_short | MicroRNAs in health and disease |
| title_sort | micrornas in health and disease |
| topic | micrornas biomarkers transcriptome |
| url | http://www.jcsr.co.in/article.asp?issn=2277-5706;year=2017;volume=6;issue=1;spage=25;epage=34;aulast=Rama;type=0 |
| work_keys_str_mv | AT krama micrornasinhealthanddisease AT pvlnsrinivasarao micrornasinhealthanddisease AT aparnarbitla micrornasinhealthanddisease |