A human ESC line for efficient CRISPR editing of pluripotent stem cells

Human pluripotent stem cells (hPSC) can be directed to differentiate in vitro into insulin-prorducing beta cells (SC-β). Although these cells accurately respond to glucose and can reverse diabetes in preclinical models improvments in the final cell products are desirable. For example, safety, contro...

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Bibliographic Details
Main Authors: Elad Sintov, Dario Gerace, Douglas A. Melton
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506121004384