Bioactive compounds and biological functions of medicinal plant-derived extracellular vesicles
Extracellular vesicles (EVs) are tiny lipid bilayer-enclosed membrane particles released from a variety of cell types into the surrounding environment. These EVs have massive participated in cell-to-cell communication and interspecies communication. In recent years, plant-derived extracellular vesic...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-02-01
|
| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661824000069 |
| _version_ | 1827356749405880320 |
|---|---|
| author | Siyu Hao Hongyu Yang Jiaojiao Hu Lili Luo Yuan Yuan Libing Liu |
| author_facet | Siyu Hao Hongyu Yang Jiaojiao Hu Lili Luo Yuan Yuan Libing Liu |
| author_sort | Siyu Hao |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are tiny lipid bilayer-enclosed membrane particles released from a variety of cell types into the surrounding environment. These EVs have massive participated in cell-to-cell communication and interspecies communication. In recent years, plant-derived extracellular vesicles (PDEVs) and “exosome-like” EVs populations found in distinct plants have attracted widespread attention. Especially, research on medicinal plant-derived extracellular vesicles (MPDEVs) are increasing, which are considered a kind of promising natural compound. This review summarizes current knowledge on MPDEVs in terms of bioactive compounds, including small RNA, protein, lipid, and metabolite, have been found on the surface and/or in the lumen of MPDEVs. Moreover, both in vitro and in vivo experiments have shown that MPDEVs exert broad biomedical functions, such as anti-inflammatory, anticancer, antioxidant, modulate microbiota, etc. MPDEVs may be a better substitute than animal-derived extracellular vesicles (ADEVs) because of safety and biocompatibility in the future. |
| first_indexed | 2024-03-08T05:14:27Z |
| format | Article |
| id | doaj.art-c13130a201ea4ce1b9beff7717d414be |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-08T05:14:27Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-c13130a201ea4ce1b9beff7717d414be2024-02-07T04:42:16ZengElsevierPharmacological Research1096-11862024-02-01200107062Bioactive compounds and biological functions of medicinal plant-derived extracellular vesiclesSiyu Hao0Hongyu Yang1Jiaojiao Hu2Lili Luo3Yuan Yuan4Libing Liu5National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaNational Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China; Guangxi University of Chinese Medicine, School of Pharmacy, Nanning, ChinaChina Agricultural University, Department of Nutrition and Health, Beijing, China; Guangxi University of Chinese Medicine, School of Pharmacy, Nanning, ChinaChina Agricultural University, Department of Nutrition and Health, Beijing, ChinaNational Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China; Corresponding authors.China Agricultural University, Department of Nutrition and Health, Beijing, China; Corresponding authors.Extracellular vesicles (EVs) are tiny lipid bilayer-enclosed membrane particles released from a variety of cell types into the surrounding environment. These EVs have massive participated in cell-to-cell communication and interspecies communication. In recent years, plant-derived extracellular vesicles (PDEVs) and “exosome-like” EVs populations found in distinct plants have attracted widespread attention. Especially, research on medicinal plant-derived extracellular vesicles (MPDEVs) are increasing, which are considered a kind of promising natural compound. This review summarizes current knowledge on MPDEVs in terms of bioactive compounds, including small RNA, protein, lipid, and metabolite, have been found on the surface and/or in the lumen of MPDEVs. Moreover, both in vitro and in vivo experiments have shown that MPDEVs exert broad biomedical functions, such as anti-inflammatory, anticancer, antioxidant, modulate microbiota, etc. MPDEVs may be a better substitute than animal-derived extracellular vesicles (ADEVs) because of safety and biocompatibility in the future.http://www.sciencedirect.com/science/article/pii/S1043661824000069Medicinal plant-derived extracellular vesiclesBioactive compoundsBiomedical functionsSafety and biocompatibility |
| spellingShingle | Siyu Hao Hongyu Yang Jiaojiao Hu Lili Luo Yuan Yuan Libing Liu Bioactive compounds and biological functions of medicinal plant-derived extracellular vesicles Pharmacological Research Medicinal plant-derived extracellular vesicles Bioactive compounds Biomedical functions Safety and biocompatibility |
| title | Bioactive compounds and biological functions of medicinal plant-derived extracellular vesicles |
| title_full | Bioactive compounds and biological functions of medicinal plant-derived extracellular vesicles |
| title_fullStr | Bioactive compounds and biological functions of medicinal plant-derived extracellular vesicles |
| title_full_unstemmed | Bioactive compounds and biological functions of medicinal plant-derived extracellular vesicles |
| title_short | Bioactive compounds and biological functions of medicinal plant-derived extracellular vesicles |
| title_sort | bioactive compounds and biological functions of medicinal plant derived extracellular vesicles |
| topic | Medicinal plant-derived extracellular vesicles Bioactive compounds Biomedical functions Safety and biocompatibility |
| url | http://www.sciencedirect.com/science/article/pii/S1043661824000069 |
| work_keys_str_mv | AT siyuhao bioactivecompoundsandbiologicalfunctionsofmedicinalplantderivedextracellularvesicles AT hongyuyang bioactivecompoundsandbiologicalfunctionsofmedicinalplantderivedextracellularvesicles AT jiaojiaohu bioactivecompoundsandbiologicalfunctionsofmedicinalplantderivedextracellularvesicles AT lililuo bioactivecompoundsandbiologicalfunctionsofmedicinalplantderivedextracellularvesicles AT yuanyuan bioactivecompoundsandbiologicalfunctionsofmedicinalplantderivedextracellularvesicles AT libingliu bioactivecompoundsandbiologicalfunctionsofmedicinalplantderivedextracellularvesicles |